Leukemias / Lymphomas: Hodgkin Lymphoma
Alternate Names: Hodgkin disease
Hodgkin lymphoma is a cancer characterized by progressive enlargement of affected lymph nodes and sometimes spread to the spleen, liver, bone marrow, bones, or lungs.
- Every year in the United States, 6,000 to 7,000 new cases of Hodgkin lymphoma are diagnosed (in adults and children)..
- In the United States and northern Europe, Hodgkin lymphoma is rare before the age of five, with a gradual rise in incidence until adolescence and a peak in the 20s and another peak later in adulthood.
- Boys are more likely than girls to develop Hodgkin lymphoma.
- Siblings of patients have a slightly increased risk of developing the disease.
- The virus that causes mononucleosis (Epstein-Barr virus) is believed to play a role in the development of some cases of Hodgkin lymphoma.
- The survival rate today for low-stage Hogkin lymphoma is greater than 90 percent.
- The survival rate for advanced disease is greater than 80 percent.
- Newer risk-adapted therapies are under investigation to determine if it is possible to reduce the amount of treatment (which should reduce the long-term side effects of heart and lung disease and second cancers) and still maintain cure rates. Three treatment protocols are currently available at St. Jude for patients with Hodgkin lymphoma: HOD99, HOD05 and HOD08.
- The Hodgkin consortium is based at St Jude and led by Monika Metzger, MD. It includes the following institutions: Dana Farber Cancer Institute, Stanford Comprehensive Cancer Center, Massachusetts General Hospital Cancer Center and Maine Medical Center. Collaborators work together to develop improved treatment strategies for Hodkgin lymphoma patients.
- Long term side effects in survivors of Hodgkin lymphoma are being investigated in the SJLIFE studies 4,5 and 16.
- Laboratory-based scientists are working with physicians to better understand the role that viruses like the Epstein-Barr virus play in the development of Hodgkin lymphoma. This information will be helpful in developing new approaches to treat Hodgkin lymphoma.
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