Method for Enhancing Recombinant Antibody Production (SJ-08-0032)

Technology Name
(St. Jude Reference #)
Method for Enhancing Recombinant Antibody Production (SJ-08-0032)
Description A method for enhancing recombinant antibody production by co-expressing a recombinant antibody with the ERp23 protein. The ERp23 protein facilitates oxidative folding and stability of the recombinant antibody which enhances its production. This invention may be used in the production of therapeutic antibodies.
Keywords  Therapeutic antibody production
Granted Patents or Published Applications U.S. Patent No. 8,030,0027
Related Scientific References Shimizu Y, Meunier L, Hendershot LM; pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17013-8.
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Last update: April 2014