Cynthia Wetmore, MD, PhD

Cynthia Wetmore, MD, PhD

Associate Member, St. Jude Faculty
Director, Molecular Clinical Trials Shared Resource




Neuro Oncology


BS - Harvard University
PhD - Karolinska Institute, Stockholm, Sweden (1992)
MD - University of Minnesota Medical School (1995)

Research Interests

Clinical Interests

Selected Publications

Palmer SL, Glass JO, Li Y, Ogg R, Qaddoumi I, Armstrong GT, Wright KD, Wetmore C, Broniscer A, Gajjar A, Reddick WE. White matter integrity is associated with information processing speed in patients treated for a posterior fossa brain tumor. Neuro-oncology 2013 (in press).

Colvin Wanshura LE, Galvin KE, Ye H, Fernandez-Zapico ME, Wetmore C. Sequential activation of Snail1 and N-myc modulates Sonic hedgehog induced transformation of neural cells. Cancer Res Aug 1;71(15):5336-45, 2011. Epub 2011 Jun 6.

Nageswara Rao AA, Ye H, Decker PA, Howe CL, Wetmore C. Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice. J Neurooncol Apr 17 2011 [Epub ahead of print]

Rao AA, Laack NN, Giannini C, Wetmore C. Plepmorphic xanthoastrocytoma in children and adolescents. Pediatr Blood Cancer 55(2):290-4, 2010.

Jicha GA, Glantz J, Clarke MJ, Lehwald LM Russo DP, Giannini C, Wald JT, Uhm J, Kumar N, Aksamit AJ, Wetmore CJ. Diffuse leptomemingeal gliomatosis. Eur Neurol 62(1):16-22, 2009.

Leonard J, Ye H, Wetmore C*, Karnitz L.* Sonic hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability. J Cell Biol 183(3):385-391, 2008 *Co-senior authorship.

Galvin KE, Ye H, Erstad DJ, Feddersen R, Wetmore C. Gli1-induces G2/M arrest in normal but not tumor-derived neural stem cells” February 14, 2008 [epub ahead of print] Stem Cells 26:1027-1036, 2008.

Galvin KE, Ye H, Wetmore C. Differential gene induction by genetic and ligand-mediated activation of the Sonic hedgehog pathway in neural stem cells. Dev Biol 308(2):331-342, 2007.

Lee Y, Miller HL, Jensen P, Hernan R, Connelly M, Wetmore C, Zindy F, Roussel M, Curran T, Gilbertson R, McKinnon PJ. A molecular fingerprint for medulloblastoma. Cancer Res 63:5428-5437, 2003.

Yang WQ, Senger D, Muzik H, Shi ZQ, Brasher PMA, Newcastle MB, Hamilton M, Wolff J, Wetmore C, Curran T, Lee PWK, Forsyth PA. Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma. Cancer Res 63(12):3162-3172, 2003.

Li L, Connelly MC, Wetmore C, Curran T, Morgan JI. Mouse embryos cloned from brain tumors. Cancer Res 63(11):2733-2736, 2003.

Karchewski LA, Gratto KA, Wetmore CJ, Verge VMK. Dynamic patterns of BDNF expression in injured sensory neurons: differential modulation by NGF and NT-3. Eur J Neurosci 16(8):1449-1462, 2002.

Gilbertson RJ, Bentley L, Hernan R, Junttila TT, Frant AJ, Haapasalo H, Connelly M, Wetmore C, Curran T, Elenius K, Ellison DW. ERBB Receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. Clin Cancer Res 8(10):3054-3064, 2002.

Weiss WA, Israel M, Cobbs C, Holland E, James CD, Louis DN, Marks C, McClatchey A, Roberts T, VanDyke T, Wetmore C, Chiu I, Giovannini M, Guha A, Higgins R, Marino S, Radovanovic I, Reilly K, Adalpe K. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene 21:7453-7463, 2002.

Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JYH, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA, Poggio T, Mukherjee S, Califano A, Stolovitzky G, Louis DN, Mesirov JP, Lander ES, Golub T. Prediction of central nervous system embryonal tumor outcome based on gene expression. Nature 415(6870)436-442, 2002.

Wetmore C, Eberhart DE, Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61(2):513-516, 2001.

De Giorgio R, Arakawa J, Wetmore CJ, Sternini C. Neurotrophin-3 and neurotrophin receptor immunoreactivity in peptidergic enteric neurons. Peptides 21(9):1421-1426, 2000.

Wetmore C, Eberhart DE, Curran T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germline mutation of patched. Cancer Res 60(8):2239-2246, 2000.

Andersson H, Wetmore C, Lindqvist E, Luthman J, Olson L. Trimethyltin exposure in the rat induces delayed changes in brain-derived neurotrophic factor, fos and heat shock protein 70. Neurotoxicology 18(1):147-159, 1997

Schmidt-Kastner R, Wetmore C, Olson L. Comparative study of brain-derived neurotrophic factor mRNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex. Neuroscience 74:161-183, 1996.

Schmidt-Kastner R, Humpel C, Wetmore C, Olson L. Cellular hybridization for BDNF, trkB and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus. Exp Brain Res 107:331-347, 1996.

Wetmore C, Olson L. Neuronal and non-neuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia of rat suggest new intercellular trophic interactions. J Comp Neurol 353:143-159, 1995.

Humpel C, Giacobini MMJ, Wetmore C, Olson L. Brain-derived neurotrophic factor and trkB receptor mRNAs in grafts of cortex cerebri. Exp Neurol 127:171-177, 1994.

Wetmore C, Olson L, Bean AJ. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. J Neurosci 14:1688-1700, 1994.

Humpel C, Wetmore C, Olson L. Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol-induced epileptic seizures. Neuroscience 53:909-918, 1993.

Freedman R, Wetmore C, Strömberg I, Leonard S, Olson L. Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression. J Neurosci 13:1965-1975, 1993.

Wetmore CJ, Cao Y, Pettersson RF, Olson L. Brain-derived neurotrophic factor (BDNF) peptide antibodies: characterization using a Vaccinia virus expression system. J Histochem Cytochem 41:521-533, 1993.

Meyer M, Matsuoka I, Wetmore C, Olson L, Thoenen H. Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J Cell Biol 119:45-54, 1992.

Wetmore C, Bygdeman M, Olson L. High and low-affinity NGF receptor mRNAs in human foetal spinal cord and ganglia. Neuroreport 3:689-692, 1992.

Wetmore C, Cao Y, Pettersson R, Olson L. Brain-derived neurotrophic factor: Subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies. Proc Natl Acad Sci 88:9843-9847, 1991.

Ernfors P, Wetmore C, Eriksdotter-Nilsson M, Bygdeman M, Strö`mberg I, Wetmore C, Olson L, Persson H. The nerve growth factor gene is expressed in both neuronal and non-neuronal tissues in the human embryo. Int J Dev Neurosci 9:57-66, 1991.

Wetmore C, Elde R. Detection and characterization of sensory microganglion associated with the spinal accessory nerve. J Comp Neurol 305:148-163, 1991.

Ernfors P, Wetmore C, Olson L, Persson H. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron 5:511-526, 1990.

Wetmore C, Ernfors P, Persson H, Olson L. Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp Neurol 109:141-152, 1990.

Strömberg I, Wetmore CJ, Ebendal T, Ernfors P, Persson H, Olson L. Rescue of forebrain cholinergic neurons after implantation of genetically modified cells producing recombinant NGF. J Neurosci Res 25:405-411, 1990.

Last update: February 2013