Alberto Pappo, MD, Armita Bahrami, MD, Michael Dyer, PhD, St. Jude Children’s Research Hospital

Genomic Analysis of Solid Tumors

Solid tumors, which arise in the peripheral nervous system, muscle, or bone, represent some of the most devastating and poorly understood childhood diseases. Investigators in the Developmental Biology & Solid Tumor Program of the St. Jude Comprehensive Cancer Center are identifying the specific oncogenetic events that occur during development to generate preclinical models of disease and learn how the underlying mechanisms of solid tumorigenesis can be exploited to improve therapeutic approaches. The first solid tumors studied through the Pediatric Cancer Genome Project (PCGP) are retinoblastoma, rhabdomyosarcoma, and neuroblastoma.