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Charles Sherr, M.D., Ph.D., a member of the Genetics & Tumor Cell Biology Department at St. Jude and a Howard Hughes Medical Institute investigator of St. Jude Children’s Research Hospital , is one of two scientists world wide to receive the prestigious Landon-AACR Prize for Cancer Research.
Sherr has been selected to receive Kirk A. Landon-AACR Prize for Basic Research from the Kirk A. and Dorothy P. Landon Foundation and the American Association for Cancer Research for his significant contributions to the understanding of mechanisms of cell growth control and neoplastic transformation, particularity as they relate to the mammalian cell division cycle. He will receive an unrestricted $200,000 cash award and present a scientific lecture at the April AACR annual meeting in Toronto, Canada.
“Charles Sherr’s astonishing series of discoveries has changed the way we view both the mechanics of the cell cycle and the genetics of cancer,” said Robert N. Eisenman, Ph.D. and James Roberts, M.D., Ph.D., investigators with the Division of Basic Sciences at the Fred Hutchinson Cancer Research Center in Seattle, Washington.
Sherr, elected to the National Academy of Sciences in 1995, has received several awards and honors including the Milken Family Medical Foundation Award for Cancer Research, Ernst W. Bertner Award for Cancer Research, Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research and the Pezcoller-AACR International Award for Cancer Research. Sherr and Dawn Quelle, Ph.D., a postdoctoral fellow in his lab, discovered the tumor suppressor gene ARF in 1995 and received a patent for it in 1999 from the U.S. Patent and Trademark Office. This patent was the first awarded for the complete ARF gene.
Sherr joined the St. Jude staff in 1983, was appointed an investigator of the Howard Hughes Medical Institute in 1988 and in 1995 was elected to the prestigious National Academy of Sciences, which advises the federal government on science and technology issues. Before coming to St. Jude, Sherr was chief of the viral pathology section in the National Cancer Institute’s division of cancer cause and prevention.
The AACR is a professional organization of more than 15,000 laboratory and clinical scientists engaged in cancer research, and the Landon-AACR Prize is designed to bring heightened public attention to landmark achievements in the continuing effort to prevent and cure cancer through quality research. Through Dr. Sherr’s discoveries and work, the way scientists view the mechanics of the cell cycle and define the two major tumor suppressive pathways mutated in human cancer has improved.
St. Jude Children’s Research Hospital
St. Jude Children’s Research Hospital, in Memphis, Tennessee, was founded by the late entertainer Danny Thomas. The hospital is an internationally recognized biomedical research center dedicated to finding cures for catastrophic diseases of childhood. The hospital’s work is supported through funds raised by ALSAC. ALSAC covers all costs not covered by insurance for medical treatment rendered at St. Jude Children's Research Hospital. Families without insurance are never asked to pay.