Dr. Thirumala-Devi Kanneganti

Thirumala-Devi Kanneganti, PhD

Member, St. Jude Faculty



Contact Information

Thirumala-Devi Kanneganti, PhD
MS 351, Room E7004
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: thirumala-devi.kanneganti@stjude.org
Phone: (901) 595-3634
FAX: (901) 595-5766



Research Interests

Molecular Mechanisms of Host Defense and Inflammation

Our research aims to understand how the innate immune system recognize and respond to pathogens and how mutations in these sensing systems affect the development of infectious, inflammatory, and autoimmune diseases in humans. Our initial studies examined the roles of TLRs, NLRs and their adaptor proteins in response to certain microbial components (Nature 440(7081):233-36; Nature Immunology 7(6):576-82; JBC 281(48):36560-68; Journal of Immunology 178(12):8022-27; Immunity 26(4):433-43). Ongoing studies are investigating the sophisticated system governing activation of signaling cascades and the mechanisms involved (Mol Cell Proteomics 7(12):2350-63; Blood 113(12):2742-5; Immunity 32(3):379-91). Work in the lab is funded by an RO1 grant from NIAMS, a NIAID Centers of Excellence for Influenza Research and Surveillance pilot project, a Cancer Center Support grant from NCI, and by ALSAC/St. Jude Children’s Research Hospital.

Selected Publications

Lukens JR, Vogel P, Johnson GR, Kelliher MA, Iwakura Y, Lamkanfi M, Kanneganti TD. RIP1-driven autoinflammation targets IL-1? independently of inflammasomes and RIP3. Nature May 26, 2013.

Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol 14(5):480-488, 2013.

Lukens JR, Kanneganti TD. Fat chance: not much against NKT cells. Immunity 37(3):447-449, 2012.

Anand PK, Malireddi RK, Lukens JR, Vogel P, Bertin J, Lamkanfi M, Kanneganti TD. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488(7411):389-393, 2012.

Kanneganti TD, Dixit VD. Immunological complications of obesity. Nat Immunol 13(8):707-712, 2012.

Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti TD. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20(5):649-60, 2011.

Ippagunta SK, Malireddi MRK, Shaw PJ, Neale GA, Walle LV, Green DR, Fukui Y, Lamkanfi M, Kanneganti TD. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat Immunol September 4, 2011.

Shaw PJ, Barr MJ, Lukens JR, McGargill MA, Chi H, Mak TW, Kanneganti TD. Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. Immunity 34(1):75-84, 2011.

Stienstra R, van Diepen JA, Tack CJ, Zaki MH, van de Veerdonk FL, Perera D, Neale GA, Hooiveld GJ, Hijmans A, Vroegrijk I, van den Berg S, Romijn J, Rensen PC, Joosten LA, Netea MG, Kanneganti TD. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A August 29, 2011.

Lamkanfi M, Walle LV, Kanneganti TD. Deregulated inflammasome signaling in disease. Immunol Rev 243(1): 163-73, 2011.

Zaki MH, Lamkanfi M, Kanneganti TD. The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol 32(4):171-9, 2011.

Ellebedy AH, Lupfer C, Ghoneim HE, DeBeauchamp J, Kanneganti TD, Webby RJ. Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. Proc Natl Acad Sci U S A 108(7):2927-32, 2011.

Shaw PJ, McDermott MF, Kanneganti TD. Inflammasomes and autoimmunity. Trends Mol Med 17(2):57-64, 2011.

Zaki MH, Vogel P, Body-Malapel M, Lamkanfi M, Kanneganti TD. IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol 185(8):4912-20, 2010.

Malireddi RKS, Ippagunta S, Lamkanfi M, Kanneganti TD. Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes. J Immunol 185(6):3127-30, 2010.

Ippagunta SK, Brand DD, Luo J, Boyd KL, Calabrese C, Stienstra R, Van de Veerdonk FL, Netea MG, Joosten LAB, Lamkanfi M, Kanneganti TD. Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis. J Biol Chem 285(16):12454-62, 2010.

Hasan Z, Ippagunta S, Boyd KL, Kastan MB, Lamkanfi M, Kanneganti TD. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32(3):379-91, 2010.

Shaw PJ, Lukens R, Burns S, Chi H, McGargill MA, Kanneganti TD. Cutting Edge: Critical Role for PYCARD/ASC in the Development of Experimental Autoimmune Encephalomyelitis. J Immunol 184(9):4610-4, 2010.

Ippagunta S, Brand DD, Luo J, Boyd K, Calabrese C, Stienstra R, Van de Veerdonk FL, Van den Berg WB, Netea MG, Joosten LA, Lamkanfi M, KannegantiTD. Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis. J Biol Chem 285(16):12454-62, 2010.

Lupfer C, Kanneganti TD. Virus detection by the NLR inflammasomes. Book chapter in “Progress in Inflammation Research." M. J. Parnham (ed): Springer Series/4983, 2010.

Hasan Z, Kanneganti TD. The Inflammasomes. Book chapter in “Regulation of Innate Immune Function.” Research Signpost, publishers of STM books of scientific distinction, 2010.

Shaw PJ, Lamkanfi M, Kanneganti TD. NOD-like receptor signaling beyond the inflammasome. Eur J Immunol 40(3): 624-627, 2010.

Butchar JP, Mehta P, Justiniano SE, Guenterberg KD, Kondadasula SV, Mo X, Chemudupati M, Kanneganti TD, Amer A, Muthusamy N, Jarjoura D, Marsh CB, Carson WE 3rd, Byrd JC, Tridandapani S. Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy. Clin Cancer Res 16(7):2065-75, 2010.

Lamkanfi M, KannegantiTD. Caspase-7: A protease involved in apoptosis and inflammation. Int J Biochem and Cell Biol 42(1):21-4, 2010.

Lamkanfi M, Malireddi RK, Kanneganti TD. Fungal zymosan and mannan activate the cryopyrin inflammasome.J Biol Chem 284(31):20574-81, 2009.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD*, Amer AO. Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection. PLoS Pathogens 5(4):e1000361, 2010.

Van de Veerdonk FL, Joosten LA, Devesa I, Mora-Montes HM, Kanneganti TD, Dinarello CA, van der Meer JW, Gow NA, Kullberg BJ,Netea MG. Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans.J Infect Dis 99(7):1087-96, 2009.

Lamkanfi M, Moreira LO, Makena P, Spierings DC, Boyd K, Murray PJ, Green DR, Kanneganti TD. Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood 113(12):2742-5, 2009.

Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30(4):566-75, 2009.

Last update: June 2013