Jian Zuo, PhD

Jian Zuo, PhD

Member, St. Jude Faculty

Departments

Developmental Neurobiology

Contact Information

Jian Zuo, PhD
Developmental Neurobiology
Room D2006E
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: jian.zuo@stjude.org
Phone: (901) 595-3891
FAX: (901) 595-2270

Education

BS - Huazhong Univ. Science & Tech., Wuhan, P.R. China (1985)
MS - Huazhong Univ. Science & Tech., Wuhan, P.R. China
PhD - University of California, San Francisco, CA (1993)


Research Interests

Hair cells function and regeneration in the mouse inner ear has been the main focus of my research.


Selected Publications

Mellado Lagarde MM, Drexl M, Lukashkin AN, Zuo J, Russell IJ.  Prestin’s role in cochlear frequency tuning and transmission of mechanical responses to neural excitation. Current Biology 18: 200-202, 2008.

Wu X, Wang X, Gao J, Yu Y, Jia S, Zheng J, Dallos P, He DZZ, Cheatham M, Zuo J. Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification. Brain Res 1210: 20-28, 2008.

Dallos P, Wu X, Cheatham MA, Gao J, Zheng J, Anderson CT, Jia S, Wang X, Cheng WHY, Sengupta S, He DZZ, Zuo J. Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron 58(3): 333-339, 2008.

Weber T, Corbett MK, Chow LML, Valentine MB, Baker SJ, Zuo J. Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells. Proc Natl Acad Sci USA 105(2): 781-5, 2008.

Wu X, Currall B, Yamashita T, Parker LL, Hallworth R, Zuo J. Prestin-prestin and prestin-GLUT5 interactions in HEK293T cells. Devel Neurobiol (formerly J Neurobiol) 67(4):483-97, 2007.

Maison SF, Parker LL, Young L, Adelman JP, Zuo J, Liberman MC Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance. J Neurophysiol 97(4):2930-6, 2007.

Gao J, Maison SF, Wu X, Hirose K, Jones SM, Bayazitov I, Tian Y, Mittleman G, Matthews D, Zakharenko S, Liberman MC, Zuo J. Orphan glutamate receptor d1 subunit required for high-frequency hearing. Mol Cell Biol 27(12):4500–12, 2007.

Gao J, Wang X, Wu X, Aguinaga S, Huynh K, Jia S, Matsuda K, Patel M, Zheng J, Cheatham M, He D, Dallos P, Zuo J. Prestin-based outer hair cell somatic motility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier. Proc Natl Acad Sci USA 104(30):12542-12547, 2007.

Yu S, Hackmann K, Gao J, He X, Piontek K, González MAG, Menezes LF, Xu H, Germino GG, Zuo J, Qian F. Essential role of cleavage of polycystin-1 at G-protein coupled-receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci USA 104(47):18688-93, 2007.

Parker LL, Gao J, Zuo J. Absence of hearing loss in a mouse model for DFNA17 and MYH9-related disease: the use of public gene-targeted ES cell resources. Brain Res 1091(1):235-42, 2006.

Chow L, Tian Y, Weber T, Corbett M, Zuo J, Baker SJ. Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Devel Dyn 235(11):2991-8, 2006.

Habiby Kermany M, Parker LL, Guo YK, Miller D, Swanson D, Yoo TJ, Goldowitz D, Zuo J. Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen. Hearing Res 220(1-2):76-86, 2006.

Liu J, Huang Q, Higdon J, Liu W, Tao X, Yamashita T, Cheon K, Cheng C, Zuo J. Distinct gene expression profiles and reduced JNK signaling in retinitis pigmentosa caused by RP1 mutations. Hum Mol Genet 14(19): 2945-2958, 2005.

Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, Li T. Elestic fiber homeostasis requires lysyl oxidase-like 1. Nature Genet 36:178-182, 2004.

Wu X, Gao J, Guo Y, Zuo J. Hearing threshold elevation precedes hair cell loss in prestin knockout mice. Mol Brain Res 126:30-37, 2004.

Li M, Tian Y, Fritzsch B, Gao J, Wu X, Zuo J. An inner hair cell-Cre expressing transgenic mouse line. Genesis 39:173-177, 2004.

Tian Y, Li M, Fritzsch B, Zuo J. Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing prestin. Devel Dyn 231:199-203, 2004.

Fernandez-Gonzalez A, La Spada AR, Treadaway J, Higdon JC, Harris BS, Sidman RL, Morgan JI, Zuo J. Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1. Science 295:1904-1906, 2002.

Gao J, Cheon K, Nusinowitz S, Liu Q, Bei D, Atkins K, Azimi A, Daiger SP, Farber DB, Heckenlively JR, Pierce EA, Sullivan LS, Zuo J. Progressive photoreceptor degeneration, outer segment dysplasia and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene. Proc Natl Acad Sci USA 99(8):9698-9703, 2002.

Liberman MC, Gao J, He DZZ, Wu X, Xia S, Zuo J. Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature 419:300-304, 2002.

Maison SF, Luebke AE, Liberman MC, Zuo J. Efferent protection from acoustic injury is mediated via α9 nAChR receptors on outer hair cells. J Neurosci 22(24):10838-10846, 2002.

Zuo J, Treadaway J, Buckner, TW, Fritzsch B. Visualization of a9 acetylcholine receptor expression in hair cells of transgenic mice containing a modified bacterial artificial chromosome. Proc Natl Acad Sci USA 96(24):14100-14105, 1999.

 

Last update: June 2009


 

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