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Research
| Technology Name (St. Jude Reference #) |
Oligonucleotide Array for Monitoring T Cell Receptor Diversity (SJ-04-0031) |
| Description | An oligonucleotide microarray to monitor T cell reconstitution after hematopoietic stem cell transplantation is provided. T cell receptor (TCR) repertoire CDR3 spectratyping is currently used to distinguish various T cell populations. It involves amplification of each of the V-region families in a separate reaction that is analyzed sequentially on a sequencing gel. However, spectratyping requires numerous PCR reactions and only provides a qualitative analysis. This TCRβ repertoire-based oligonucleotide microarray provides a simple, rapid high-throughput tool to quantitatively and qualitatively analyze many TCR genes for use in clinical and research applications. |
| Keywords | T cell reconstitution, T cell diversity, Stem cell transplant |
| Granted Patents or Published Applications | US Publication No. 2010/0035764A1 |
| Related Scientific References | Chen X, et al. A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation. Experimental Hematology 35 (2007) 831-841. |
| Licensing Opportunities | We are currently seeking licensing opportunities in all fields for the development of this technology. |
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2010
