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Finding Cures. Saving Children.
2003 News Release Archive
St. Jude Children's Research Hospital has joined the ranks of world-class supercomputer users around the world with the installation of an IBM computer system that can perform more than 600 billion operations per second.
St. Jude scientists have discovered a new way a crucial enzyme can be turned into a poison inside cancer cells. The discovery is an important step toward designing a new class of drugs.
Suzanne Baker, PhD, Developmental Neurobiology, has published recent research in the journal Proceedings of the National Academy of Sciences.
James Downing, M.D., chair of Pathology at St. Jude Children's Research Hospital has been awarded the distinction of AAAS Fellow. Election as a Fellow of AAAS is an honor bestowed upon members by their peers.
Investigators at St. Jude Children's Research Hospital used an experimental anti-cancer drug to prevent or reverse abnormal brain cell growth that is caused by lack of the anti-cancer gene Pten.
Survey of human genome discloses genetic fingerprints of specific subtypes of acute lymphoblastic leukemia that might one day permit simplified diagnostic tests for this cancer.
The research of James Downing, MD, Pathology, is featured in the October 31 issue of Bio-IT World.
Proof that PUMA stalks cancer cells solves a long-standing mystery of the anti-cancer role of p53
The research of Tom Curran, PhD, Developmental Neurobiology, is featured in the October 30 issue of the journal Nature.
St. Jude's groundbreaking work in gene expression profiling will be featured in the October 15 issue of the journal Blood.
St. Jude study comparing long-term outcomes of children treated for acute lymphoblastic leukemia shows that black children can do as well as white children if given equal access to latest treatments.
St. Jude part of newly formed Primary Immunodeficiency Research Consortium
Factors linked to likelihood of reporting a single health-related problem are the same for adult survivors and the general public, but aggressive therapy can have lasting effects.
Finding that an abnormally active Bcl10 gene drives B cells to become cancerous suggests blocking the gene would be an effective treatment for MALT lymphoma.
Abandonment of therapy and fatal infections are leading causes of treatment failure, but can be corrected with simple interventions.
A recent Institute of Medicine report says that as many as two-thirds of childhood cancer survivors suffer some type of delayed side-effects from the disease or treatment.
Investigators at St. Jude Children's Research Hospital and Hospital Escuela (Tegucigalpa, Honduras) have identified ways to improve treatments and cure rates for Honduran children with acute lymphoblastic leukemia (ALL).
A gene that is crucial to the development and function of an entire family of immune cells is also key to understanding why one member of that family can become cancerous.
Survivors of childhood acute lymphoblastic leukemia (ALL) who have not received radiation treatment as part of their therapy have virtually the same long-term life experiences as the general population.
St. Jude Children's Research Hospital has received approval from the Food and Drug Administration (FDA) to begin testing another part of its HIV vaccine regimen.
Investigators at St. Jude Children's Research Hospital have discovered a previously unrecognized way that certain types of cancer cells can be forced to activate a self-destruction program called apoptosis.
African-American children who have siblings with sickle cell disease (SCD) are more likely to have abnormal, "twisted" arteries in the brain, which may lead to an elevated risk of stroke in adulthood.
Nuclei removed from mouse brain tumor cells and transplanted into mouse eggs whose own nuclei have been removed, give rise to cloned embryos with normal tissues, even though the mutations causing the cancer are still present.
A team of investigators challenged the belief of how immune system cells called macrophages control their biochemical activity after being stimulated by signaling proteins called cytokines. The researchers showed that a molecular ''brake pedal'' called SOCS3 slows the biochemical activity of macrophages only if they have been stimulated by a particular cytokine.
Researchers may have found a link between progressive hearing loss and a gene called p19Ink4d (Ink4d), according to the results of a study co-authored by St. Jude investigators, that measured hearing loss in mice lacking that gene.
Investigators at St. Jude Children's Research Hospital have discovered that a gene called Prox1 turns on and off at two different times during the embryonic retina development.
Researchers at St. Jude Children's Research Hospital have overcome two major technical obstacles that currently limit the success of gene therapy for human red blood cell diseases such as beta-thalassemia and sickle cell disease.
Researchers may have found a link between progressive hearing loss and a gene called p19Ink4d (Ink4d)
Robert Webster, PhD, world-renowned virologist at St. Jude Children's Research Hospital, was one of three international experts invited by Chinese Health Officials to a summit on emerging infectious diseases...
Investigators at St. Jude Children's Research Hospital have discovered numerous genes that alter their level of activity in characteristic patterns in response to specific chemotherapy treatments.
Next month St. Jude Children's Research Hospital will become the only pediatric cancer research center in the United States to open a Good Manufacturing Practices (GMP) facility for producing vaccines, drugs, proteins, gene-based molecules and ...
A counseling program developed at St. Jude Children's Research Hospital is the first of its kind to show success in reducing future intentions to use tobacco among pre-adolescents and adolescents who survived cancer.
Scientists at St. Jude Children's Research Hospital announced today the development of a vaccine against H5N1, a new lethal influenza virus that triggered the World Health Organization (WHO) to declare a pandemic alert in February 2003.
Scientists at St. Jude Children's Research Hospital have discovered how a single enzyme called E1 performs a rapid-fire, three-part chemical makeover of a protein that helps control some of the most fundamental biochemical processes of the human cell.
A new Internet connection, provided by the University of Memphis' FedEx Technology Institute, will link scientists at St. Jude Children's Research Hospital to the next generation Internet, termed "Internet 2" or "I2."
Investigators at St. Jude Children's Research Hospital have discovered that a protein causing mature cells to commit suicide also helps primitive muscle cells called myoblasts fuse together, allowing them to develop into muscles...
Charles Sherr, M.D., Ph.D., a member of the Genetics & Tumor Cell Biology Department at St. Jude and a Howard Hughes Medical Institute investigator, is one of two scientists world wide to receive the prestigious Landon-AACR Prize for Cancer Research.
Investigators showed how cooperation between influenza virus and bacterial pneumonia infections can be foiled by treating patients with oseltamivir. The drug offers protection against pneumonia by blocking the activity of neuraminidase, a flu virus enzyme that strips lung cells of sialic acid molecules.
Researchers discovered that the Arf gene was once moderately effective in slowing down cellular reproduction until it linked up with a more efficient set of genes to create a powerful anti-cancer response. Arf have evolved to slow the cell's metabolism and growth by limiting production of ribosomes, which guide production of all other cellular proteins.
Dr. Andrew Davidoff awarded ACGT Young Investigators national grant for work in the development of anti-angiogenic gene therapy for neuroblastoma, a deadly form of childhood cancer
Researchers have discovered a critical, early step in the growing vertebrate embryo that is required for the proper development of a major part of what is often called the most complex structure in the universe-the human brain.
Scientists have discovered a novel biochemical process that plays a critical role in helping cells in the body respond to DNA damage, such as that caused by exposure to radiation, environmental toxins or free radicals.
