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(St. Jude Reference #)
|Test for Identifying Allogenic Stem Cell Transplant Donors (SJ-10-0024)|
Allogenic hematopoietic stem cell transplantation (HSCT) is often performed for patients with acute lymphoblastic leukemia and acute myelogenous leukemia, chronic myelogenous leukemia and chronic lymphocytic leukemia, Non-Hodgkin's lymphoma and Hodgkin's lymphoma, multiple myeloma, aplastic anemia, sickle cell disease and thalassemia. Killer cell immunoglobulin like receptors (KIRs) found on natural killer (NK) cells, and their HLA-ligands are important determinants for allogenic HSCT. Researchers at St. Jude found that variations in the genetic structure of the KIRs result in functional differences in NK cells and developed an expedient method for identifying optimal donors. The single-nucleotide polymorphism (SNP) assay types various allele groups of KIR2DL1 with distinct functional properties based on polymorphism at position 245. They also established a SNP assay to type different KIR ligands based on polymorphism at position 77 in HLA-C and position 83 in HLA-B and -A. In addition to providing valuable information about a potential donor, these SNP assays for KIR and KIR ligand typing are much cheaper and faster than existing high-resolution typing.
|Keywords||Natural killer cell; Killer cell immunoglobulin-like receptor; KIR; Human leukocyte antigen; Single-nucleotide polymorphism; Allogenic hematopoietic stem cell transplantation|
|Granted Patents or Published Applications||Provisional patent application filed and available under confidentiality.|
|Related Scientific References||Bari R, Leung M, Turner VE, Embrey C, Rooney B, Holladay M, Leung W. Molecular determinant-based typing of KIR alleles and KIR ligands. Clin Immunol. 2011 Mar;138(3):274-81.|
|Licensing Opportunities||We are currently seeking licensing opportunities in all fields for the development of this technology.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: January 2012