Richard Smeyne, PhD

Richard J. Smeyne, PhD

Associate Member, St. Jude Faculty

Departments

Developmental Neurobiology

Contact Information

Richard Smeyne, PhD
Developmental Neurobiology
MS123, Roon D2025F
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: richard.smeyne@stjude.org
Phone: (901) 595-2830
FAX: (901) 595-3143

Education

BS - St. Joseph's University, Philadelphia, PA (1981)
MA - University of Hartford, West Hartford, CT (1983)
PhD - Thomas Jefferson University, Philadelphia, PA (1989)
Postdoctoral Training - Department of Neuroscience, Roche Institute of Molecular Biology, Nutley, NJ

Research Interests

  • Genetics of neurodegeneration
  • Parkinson’s disease
  • Effect of drugs of abuse on neural development and cerebellar development

Effects of exposure to drugs of abuse on the development of the CNS

Genes that regulate sensitivity to the Parkinsonian drug MPTP

The role of environment in neuroprotection


Selected Publications

Pattarini R, Smeyne RJ, Morgan JI. Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson’s disease. Neuroscience 145:654-668, 2007.

Smeyne M, Boyd J, Shepherd KR, Jiao Y, Pond BB, Hatler M, Wolf R, Henderson C, Smeyne RJ. GSTπ expression mediates dopaminergic neuron sensitivity in experimental parkinsonism. PNAS 104(6):1977-1982, 2007.

Lloyd SA, Faherty CJ, Smeyne RJ. Adult and in utero exposure to cocaine alters sensitivity to the Parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience 137:905-913, 2006.

Johnson DK, Rinchik EM, Moustaid-Moussa N, Miller DR, Williams RW, Michaud EJ, Jablonski MM, Elberger A, Hamre K, Smeyne R, Chesler E, Goldowitz D. Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice. Age 27:75-90. 2006

Smeyne M, Jiao Y, Shepherd KR, Smeyne RJ. Glia cell number modulates sensitivity to MPTP in mice. Glia 52:144-152, 2005.

Jackson-Lewis V, Smeyne RJ. MPTP and SNpc DA neuronal vulnerability: Role of Dopamine, superoxide and nitric oxide in neurotoxicity. Neurotox Res 7:193-201, 2005.

Smeyne RJ, Jackson-Lewis V. The MPTP model of Parkinson’s disease. Brain Res Mol Brain Res 134: 57-66, 2005.

Faherty CJ, Shepherd KR, Herasimtschuk A, Smeyne RJ. Environmental enrichment eliminates neuronal death in experimental Parkinsonism. Mol Brain Res 134: 170-179, 2005.

Lewis PM, Griti-Linde A, Smeyne R, Kottmann A, McMahon AP. Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol 270:393-410, 2004.

Jensen P, Smeyne RJ, Zoghbi HY, Goldowitz D. Analysis of cerebellar development in math1 null embryos and chimeras. J Neurosci 24:2202-2211, 2004.

Zindy F, Nilsson LM, Nguyen L, Meunier C, Smeyne RJ, Rehg JE, Eberhart C, Sherr CJ, Roussel MF. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer Res 63: 5420-5427, 2003.

Smeyne RJ, Pollack JD. Foreword. Special Issue on Role of prenatal drugs of abuse on neuronal development. Brain Res Dev Brain Res 147:1-2, 2003

Lloyd SA,Wensley B, Faherty CJ, Smeyne RJ. Regional differences in cortical dendrite morphology following in utero exposure to cocaine. Brain Res Dev Brain Res 147:59-66, 2003.

Faherty CJ, Kerley D, Smeyne RJ. A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment. Brain Res Dev Brain Res 141: 55-61, 2003.

Cook R, Lu L, Gu J, Williams RW, Smeyne RJ. Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Brain Res Mol Brain Res 110:279-288, 2003.

Smeyne M, Smeyne RJ. Method for culturing postnatal substantia nigra as an in vitro model of experimental Parkinson’s disease. Brain Res Prot 9:105-111, 2002.

Leimig T, Mann L, del Pilar Martin M, Bonten E, Persons D, Knowles J, Allay JA, Cunningham J, Nienhuis AW, Smeyne R, d’Azzo A. Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells. Blood 99:3169-3178, 2002.

Cunningham JJ, Levine EM, Zindy F, Goloubeva O, Roussel M, Smeyne RJ. The cyclin-dependent kinase inhibitors, p19Ink4d and p27Kip1, are coexpressed in select retinal cells and act cooperatively to control cell cycle exit. Mol Cell Neurosci 19:359-374, 2002.

McKeller RN, Fowler JL, Cunningham JJ, Warner N, Smeyne RJ, Zindy F, Skapek SX. The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development. PNAS 99:3848-3853, 2002.

Kwon C-H, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, and Baker SJ. Pten regulates neuronal soma size: a mouse model for Lhermitte-Duclos disease. Nature Genetics 29:404-411, 2001.

Smeyne M, Goloubeva O, Smeyne RJ. Strain–dependent susceptibility to MPTP and MPP+-induced Parkinsonism is determined by glia. Glia 34:73-80, 2001.

Chen S-C, Cunningham JJ, Smeyne RJ. Expression of OB receptor splice variants during prenatal development of the mouse. J Recept Signal Transduct Res 20:87-103, 2000.

Zindy F, Cunningham JJ, Sherr CJ, Jogal S,  Smeyne RJ, Roussel M. Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases. Proc Nat Acad Sci USA  96:13462-13467, 1999.

Faherty C, Xanthoudakis S, Smeyne RJ. Caspase-3 dependent neuronal death in the hippocampus following kainic acid treatment. Mol Brain Res 70:159-163, 1999.

Hamre K, Tharp R, Poon K, Smeyne RJ. Quantitative analysis of the substantia nigra pars compacta neurons following MPTP administration in seven strains of Mus musculus:  Evidence that the susceptibility trait is autosomal dominant. Brain Res 828:91-103, 1999.

Chen S-C, Kochan JP, Campfield A, Burn P, Smeyne RJ. Splice variants of the OB receptor gene are differentially expressed in brain and peripheral tissues of mice. J Recept Signal Transduct Res 19:245-266, 1999.

 

Last update: March 2008

 

Email This Article Email This Article   |   Print Print