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Finding Cures. Saving Children.
2006 News Release Archive
The establishment of research ethics committees in El Salvador will enhance the ability of that country to undertake clinical trials aimed at improving cure rates of pediatric catastrophic diseases, according to investigators from St. Jude.
Mice with neuroblastoma tumors have been successfully treated with genetically modified cells that sought out the cancer cells and activated a chemo drug directly at those sites.
St. Jude researchers find that harvesting aggressive stem cells from donated bone marrow could speed rebuilding of the immune system, reduce risk of infection.
A troublesome side effect caused by some cancer drugs appears to be caused by a broken "pump" in the liver that fails to push these medicines into a "drain," according to investigators at St. Jude Children's Research Hospital.
Magnetic resonance imaging (MRI) could become a valuable tool for predicting the risk of muscle injury during and following radiation therapy, according to investigators at St. Jude Children's Research Hospital.
Scientists at St. Jude have demonstrated a new, locally applied treatment for the eye cancer retinoblastoma that not only greatly reduces the size of the tumor, but does so without causing the side effects common with standard chemotherapy.
New wave of H5N1 transmission through Asia despite containment measures highlights need for more information on movement of virus into and out of southern China, according to researchers at the University of Hong Kong in collaboration with St. Jude.
Investigators at St. Jude Children's Research Hospital have discovered in mouse models that a gene called Six3 is one of the earliest critical regulators controlling lens development in the eye of the mammalian embryo.
St. Jude researchers have discovered how cell walls from certain pneumonia-causing bacteria can cause fatal heart damage and how antibiotic therapy can contribute to this damage by increasing the number of cell wall pieces shed by dying bacteria.
Clinicians at St. Jude Children's Research Hospital have successfully demonstrated an improved technique for blood stem cell transplantations in children that shows promise for those most likely to fail standard treatment for leukemia.
Almost three-fourths of adult survivors of pediatric cancer patients diagnosed in the 1970s and 1980s have--or will develop--chronic health problems related to their cancer or its treatment, according to new study by St. Jude and other institutions.
A gene called Six2 plays a critical role in the development of the kidney by keeping a population of "parent" stem cells constantly available to produce the differentiated cells that give rise to specialized parts of the organ, according to investigators.
Investigators at St. Jude Children's Research Hospital turned up the heat on "disorderly" proteins and confirmed that most of these unruly molecules perform critical functions in the cell.
"This recognition is a terrific external indication that we are being successful in creating a great place to work at St. Jude," said William Evans, PharmD, St. Jude director and CEO.
Investigators at St. Jude Children's Research Hospital have discovered that a protein called ABCB6 plays a central role in production of a molecule that is key to the ability of red blood cells to carry oxygen, of liver cells to break down toxins.
Children with cancer who suffer hearing loss due to the toxic effects of chemotherapy might one day be able to get their hearing back through pharmacological and gene therapy, thanks to work done at St. Jude Children's Research Hospital.
A team of investigators led by St. Jude Children's Research Hospital has announced that improvements in the treatment of the childhood brain cancer medulloblastoma have significantly increased the rate of survival of children with this disease.
Statisticians at St. Jude Children's Research Hospital have developed a new technique that allows researchers to statistically analyze results of clinical trials.
A 25-year quest to identify the first biochemical step that many disease-causing bacteria use to build their membranes has led to a discovery that holds promise for effective, new antibiotics against these bacteria, according to investigators at St. Jude.
The story of what makes certain types of bacteria resistant to a specific antibiotic has a sub-plot that gives insight into the cause of a rare form of brain degeneration among children, according to investigators at St. Jude Children's Research Hospital.
Scientists at St. Jude have demonstrated that a key event during apoptosis (cell suicide) occurs as a single, quick event, rather than as a step-by-step process.
St. Jude has developed a mouse model of a severe disease of the immune system that helps explain why gene therapy used to treat children with this disease at an institution in Europe caused some of them to develop leukemia.
Children with cancer who develop anemia during chemotherapy can benefit from a weekly dose of erythropoietin. The drug reduces the need for red blood cell transfusions and improves quality of life in children whose anemia is corrected by this treatment.
A gene critical for normal mammary gland function during nursing helps trigger highly lethal leukemias when it undergoes a mutation that fuses it to another gene, according to investigators at St. Jude Children's Research Hospital.
Investigators at St. Jude Children's Research Hospital have discovered that the cells of the developing nervous system of the mammalian embryo have an exquisite sense of timing when it comes to fixing broken chromosomes.
Scientists at St. Jude Children's Research Hospital have announced that a vaccine they developed a few years ago against one antigenic variant of the avian influenza virus H5N1 may protect humans against future variants of the virus.
St. Jude Children's Research Hospital has significantly reduced the rate at which families in Recife, Brazil, abandon treatment for their children who have acute lymphoblastic leukemia, and has significantly increased the rate of event-free survival.
Investigators at St. Jude have discovered the role of several key genes in the development of the retina, and in the process have taken a significant step toward understanding how to prevent or cure the potentially deadly eye cancer retinoblastoma.
The emergence of the avian influenza virus H5N1 that is currently devastating chicken flocks in many countries and threatening to unleash a worldwide epidemic among humans has triggered a renewed interest among scientists in studying influenza A viruses.
DNA-based vaccine produced by Vical Inc. protected lab animals against animal and human flu viruses, suggesting that it could protect against avian influenza virus that adapts to humans.
Investigators at St. Jude Children's Research Hospital have used mouse models to determine why some forms of acute lymphoblastic leukemia (ALL) are extremely aggressive and resist a drug that is effective in treating a different type of leukemia.
Investigators at St. Jude Children's Research Hospital have developed a strategy to speed future development of more effective and less toxic treatments for medulloblastoma, a type of brain cancer.
St. Jude investigators have developed a simple, inexpensive test that identifies children with acute lymphoblastic leukemia who have responded well to their first round of treatment might be successfully followed up with less aggressive treatment.
Scientists at St. Jude Children's Research Hospital have given investigators around the world free access to a powerful tool for studying brain development.
Robert G. Webster, Ph.D., who holds the Rose Marie Thomas Chair at St. Jude, has been given the Distinguished Biotechnologist of the Year Award by the New Zealand Biotechnology Association for his work in virology and avian influenza.
Individuals who have a rare genetic immune system disorder that prevents them from making antibodies nevertheless appear to be moderately healthy and lead productive lives, according to results of a study by investigators at St. Jude.
New report from St. Jude suggests that use of gene-based diagnosis and treatment, more effective use of existing drugs and adoption of emerging strategies will continue to boost ALL cure rate
The caspase-8 gene plays a critical role in suppressing metastasis (spread) of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively metastasizing, according to investigators at St. Jude.
