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Hepatoblastoma is a form of liver cancer that usually occurs in infants. In contrast to hepatocellular carcinoma, it arises in an otherwise normal liver.
The cancer typically appears as an asymptomatic abdominal mass found on a routine physical examination or discovered incidentally by the parents. Other nonspecific features include weight loss, abdominal pain, loss of appetite, anemia, fever, vomiting and jaundice.
Studies at St. Jude have suggested that irinotecan may be an effective agent in some children with hepatoblastoma. This drug will be tested further in a new Children's Oncology Study that is being planned.
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