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Research
Member, St. Jude Faculty
Pharmaceutical Sciences
John Schuetz, PhD
Pharmaceutical Sciences
MS 313, Room D-1052F
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
PhD - Medical College of Virginia, Richmond (1984)
Morgan JA, Cheepala SB, Wang Y, Neale G, Adachi M, Nachagari D, Leggas M, Zhao W, Boyd K, Venkataramanan R, Schuetz JD. Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice. J Biol Chem 287(18):14456-66, 2012.
Ulrich DL, Lynch J, Wang Y, Fukuda Y, Nachagari D, Du G, Sun D, Fan Y, Tsurkan L, Potter PM, Rehg JE, Schuetz JD. ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity. J Biol Chem 287(16):12679-90, 2012.
Fukuda Y, Schuetz JD. ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol 83(8):1073-83, 2012.
Fukuda Y, Aguilar-Bryan L, Vaxillaire M, Dechaume A, Wang Y, Dean M, Moitra K, Bryan J, Schuetz JD. Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8. J Biol Chem 286(10):8481-92, 2011.
Nagai S, Takenaka K, Nachagari D, Rose C, Domoney K, Sun D, Sparreboom A, Schuetz JD. Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity. Cancer Res 71(5):1781-91, 2011.
Takenaka K, Morgan JA, Scheffer GL, Adachi M, Stewart CF, Sun D, Leggas M, Ejendal KFK, Hrycyna CA, Schuetz JD. Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. Cancer Res 67:6965-72, 2007.
Li C, Krishnamurthy PC, Penmatsa H, Marrs KL, Wang XQ, Zaccolo M, Jalink K, Li M, Nelson DJ, Schuetz JD, Naren AP. Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell 131(5):940-51, 2007.
Krishnamurthy P, Du G, Fukuda Y, Sun D, Mercer K, Wang J, Sosa-Pineda B, Murti G, Schuetz JD. Identification of a mitochondrial porphyrin transporter. Nature 443:586-9, 2006.
Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology 43(5):1013-21, 2006.
Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP, Schuetz JD. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 279:24218, 2004.
Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. Interactions between hepatic Mrp4 and Sult2A as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem 279:22250, 2004.
Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, Mercer KE, Zhuang Y, Panetta JC, Johnston B, Scheper RJ, Stewart CF, Schuetz JD. Mrp4 confers resistance to topotecan and acts as a double agent in protecting the brain from chemotherapy. Mol Cell Biol 24(17):7612-21, 2004.
Lamba JK, Adachi M, Sun D, Tammur J, Schuetz EG, Allikmets R, Schuetz JD. ABCC4 Gene Structure Reveals Phylogenetically Conserved Nonsense Exons that are Regulated by Nonsense Mediated mRNA Decay. Hum Mol Genet 12(2):99-109, 2003.
Adachi M and Schuetz JD. The therapeutic and biological importance of getting nucleotides outof cells: A case for the ABC transporters, MRP4 and 5. Invited review: Adv Drug Deliv Rev 54(10):1333-42, 2002.
Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD and Sorrentino BP1. Bcrp1 Gene Expression is Required for the Presence of Side Population Stem Cells in Murine Bone Marrow. Proc Natl Acad Sci USA 99:12339-44, 2002.
Wielinga PR, Reid G, Challa E, van der Heijden I, van Deemter L, de Haas M, Mol C, Kuil A, Groeneveld E, Schuetz J, Brouwer C, d’Abreu R, Wijnholds J, Beijnen J and Borst P. Characterization of thiopurine nucleotide transport by MRP4 and MRP5. Mol Pharmacol 62:1321-31, 2002.
Adachi M, Sampath J, Lan L-B, Tammur J, Sun D, Hargrove P, Flatley R, Tatum A, Allikmets R, Matherly L, Drake R, Schuetz J. MRP4 confers resistance to the cytotoxic effects of the antiviral ganciclovir and plays a role in the bystander effect. J Biol Chem 277(41):38998-9004, 2002.
Zhou S, Schuetz JD, Bunting KD, Colapietro A-M, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP. The ABC transporter Bcrp1/ABCB2 is expressed in a wide variety of side population stem cells and inhibits hematpoietic development with enforced expression. Nature Med 7:1028-34, 2001.
Schuetz EG, Yasuda K, Lecureur V, Assem M, Brimer C, Ramchardan V, Strom S, Kim R, Sinal C, Gonzalez F and Schuetz JD. Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction Among Nuclear Hormone Receptors, Transporters and Cytochorme P450. J Biol Chem 276:39411-8, 2001.
Sampath J, Sun D, Kidd VJ, Grenet J, Gandhi A, Shapiro LH, Wang Q, Zambetti GP and Schuetz JD. Mutant p53 cooperates with ETS and selectively upregulates MDR1not MRP1. J Biol Chem 276:39359-67, 2001.
Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Relling M, Brime C, Yasuda K, Venkataramanan R, Strom S, Thummel K, Boguski MS, Schuetz E. Sequence diversity in CYP3A promoters and characterization of the genetic basispolymorphic CYP3A5 expression. Nat Genet 27(4):383-91, 2001.
Lecureur V, Thottassery JV, Sun D, Schuetz EG, Lahti J, Zambetti GP, Schuetz JD. Mdr1b facilitates p53-mediated cell death and p53 is required for Mdr1b upregulation in vivo. Oncogene 20(3):303-13, 2001.
Ding B-C, Whetstine JR, Witt TL, Schuetz JD, Matherly LH. P53 mediated repression of human reduced folate carrier gene expression. J Biol Chem 276(12):8713-9, 2001.
Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim R, Lan L-B, Schuetz JD. Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol 57:24-35, 2000.
Schuetz EG, Umbenhauer DR, Yasuda K, Brimer C, Nguyen L, Relling MV, Schuetz JD, Schinkel AH. Altered expression of hepatic cytochromes P450 in mice deficient in one or more mdr1 genes. Mol Pharmacol 57:188-197, 2000.
Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, Kumar A, Fridland A. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 5(9):1048-1051, 1999.
(Commentary in: The Lancet: vol 354:pg 923, 1999; AIDS Alert vol 15(2) pg 24, 2000, BioWorld Today Vol 10 (168) pt 1, 1999, ReutersHealth comments: Gene may contribute to HIV resistance Health eLine 1999-08-30).
Thottassery JV, Sun D, Zambetti GP, Troutman A, Sukhatme VP, Schuetz EG, Schuetz JD. Sp1 and Egr-1 have opposing effects on the regulation of the Rat Pgp2/mdr1b gene. J Biol Chem 274:3199-3206, 1999.
Lutterbach B, Sun D, Schuetz J, Heibert SW. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21)fusion protein. Mol Cell Biol 18(6):3604-3611, 1998.
Thottassery JV, Zambetti GP, Arimori K, Schuetz EG, Schuetz JD. p53-dependent Regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. Proc Natl Acad Sci 94:11037-11042, 1997.
Last update: June 2012
