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Solid Tumor : recurrent osteosarcoma
The most common site to which osteosarcoma spreads, or metastasizes, is the lungs. The most common site of recurrence is also the lungs. This study is being done to find out if an experimental drug, saracatinib, will decrease the chances that osteosarcoma will come back in the lungs after it has already come back in the lungs once.
Saracatinib is an experimental drug that limits the movement of some cancer cells in the laboratory and decreases the spread of some tumors in mice. Saracatinib works by inhibiting a protein known as Src. Src is thought to be important for the survival of osteosarcoma cells. Some adult patients with cancer who received saracatinib had slowing of growth of their tumor. The study team does not know if saracatinib will be effective for patients with osteosarcoma. This is a randomized, double-blinded, placebo-controlled trial. This means that half of the patients will receive saracatinib and half of the patients will receive placebo (a sugar pill). Neither the patient nor the trial investigators will know if the patient is receiving saracatinib or placebo.
For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).
Sheri L. Spunt, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
Referring or consulting physicians only: firstname.lastname@example.org
For all other inquiries about St. Jude Children's Research Hospital studies: email@example.com
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.