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    Downing: News Releases & Feature Stories

    Meet our new CEO, James R. Downing, MD

    Meet our new CEO, James R. Downing, MD

    St. Jude Children's Research Hospital names James R. Downing, MD, CEO to oversee a new era of expansion, growth

    Downing, internationally recognized as a genome sequencing pioneer and member of the National Academy of Sciences’ Institute of Medicine, becomes sixth leader to serve at hospital’s helm. (James Downing, MD)

    St. Jude Children’s Research Hospital scientific director elected to Institute of Medicine

    James R. Downing, M.D., becomes hospital’s sixth IOM member

    Next-Generation Discoveries

    The Pediatric Cancer Genome Project uncovers the genetic mutations that give rise to cancer.

    Revealing the Secrets of the Genome

    Pediatric Cancer Genome Project scientists begin to uncover treasures.

    World’s largest release of comprehensive human cancer genome data helps researchers everywhere speed discoveries

    To speed progress against cancer and other diseases, the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project today announced the largest-ever release of comprehensive human cancer genome data for free access by the global scientific community. (Dr. James Downing)

    Writing the Next Chapter

    For many years, St. Jude researchers have been investigating the connection between genetics and pediatric cancer. Those approaches continue to have dramatic implications for clinical care.

    Baby, Oh Baby - Camille Davis

    The tiniest patients face the biggest odds when it comes to acute lymphoblastic leukemia. St. Jude clinicians and researchers work to change that scenario.

    Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

    The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children’s Research Hospital.

    Mutant genes identified in high-risk childhood leukemias

    A research team has pinpointed a new class of gene mutations, which identify cases of childhood acute lymphoblastic leukemia (ALL) that have a high risk of relapse and death.

    St. Jude Acute Lymphoblastic Leukemia Team recognized with prestigious science award

    Scientists at St. Jude Children’s Research Hospital who represent the interdisciplinary team studying acute lymphoblastic leukemia (ALL) have been recognized by the American Association for Cancer Research (AACR) with the AACR Team Science Award.

    Gene abnormality found to predict childhood leukemia relapse

    Scientists have identified genetic mutations that predict a high likelihood of relapse in children with acute lymphoblastic leukemia (ALL).

    St. Jude identifies genomic causes of a certain type of leukemia relapse

    Scientists at St. Jude have identified distinctive genetic changes that cause relapse in children with acute lymphoblastic leukemia (ALL).

    A closer look

    An electron microscope uses a beam of electrons to produce highly detailed images that reveal a specimen’s structure and composition. The new instrument, one of only 200 of its type in the world, is the centerpiece of a recent expansion of cellular imaging at St. Jude.

    Understanding an aggressive form of leukemia

    St. Jude researchers have discovered evidence that a series of genetic mutations work together to initiate most cases of an aggressive and often-fatal form of acute lymphoblastic leukemia (ALL). These findings provide new avenues to pursue to gain a better understanding of these disease processes and, ultimately, to develop better therapies.

    Gold in those hills

    When James Downing walked into his pathology lab one day, postdoctoral fellow Charles Mullighan was staring at his computer screen, transfixed. "He was literally white," Downing recalls. "You are not going to believe what I just found," Mullighan said.

    Leukemic cells find safe haven in bone marrow

    The cancer drug asparaginase fails to help cure some children with acute lymphoblastic leukemia (ALL) because molecules released by certain cells in the bone marrow counteract the effect of that drug, according to St. Jude investigators.

    Major gene study uncovers secrets of leukemia

    Investigators at St. Jude have discovered previously unsuspected mutations that contribute to the formation of pediatric acute lymphoblastic leukemia, the most common cancer in children.

    New leadership at St. Jude

    Former St. Jude Director Arthur W. Nienhuis, M.D., and George Simon, chair of the St. Jude Board of Governors, recently announced that William E. Evans, Pharm.D., assumed the position of St. Jude Director and CEO. Nov. 1, 2004.

    James Downing named Scientific Director

    James Downing, MD, has been named St. Jude Scientific Director. Downing, who will continue serving as Pathology chair, is looking forward to working more closely with researchers and hospital leaders throughout the institution.

    Downing research featured in Bio-IT World

    The research of James Downing, MD, Pathology, is featured in the October 31 issue of Bio-IT World.