Non-Therapeutic Protocol

NBTP01: Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas and Medulloblastoma / PNET of the Pediatric CNS

Type of Protocol/Clinical Study

Associated Solid Tumor Studies

Description

Atypical teratoid rhabdoid tumors (ATRT) and choroid plexus carcinomas (CPC) are poorly understood, highly aggressive (grow and spread quickly) tumors of the pediatric central nervous system. These tumors occur most frequently in children less than two years of age. Medulloblastoma / primitive neurorectodermal tumors (PNET) are the most common type of brain tumors occurring in children. Ependymoma is the third most common brain tumor in children. Chemotherapy alone does not work in all cases. Radiation therapy cannot be used due to the long term side effects associated with radiation given to very young children. Effective treatment options in these tumors are limited.By studying the abnormalities and changes in the tumors of these subjects, we can gain a better understanding of the biology to help to develop new and hopefully better treatment in the future.


Objectives


Eligibility

Principal Investigator

Amar Gajjar, MD

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.