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Finding Cures. Saving Children.
Martine F. Roussel, PhD
Member, St. Jude Faculty
Co-Director, Cancer Center Signal Transduction Program Recipient of a St. Jude Children's Research Hospital Endowed Chair
Professor, Department of Molecular Sciences, UT Memphis
Vice-President for the US, Eurocancer, Paris, France (2003-present)
Chair, Erasmus University of Sciences, Paris, VII France and St. Jude Exchange Program, Spring/Summer Laboratory Training for Masters Students
Departments
Genetics / Tumor Cell Biology
Contact Information
Martine Roussel, PhD
Genetics / Tumor Cell Biology
MS350, DTRT Room 5006C
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: martine.roussel@stjude.org
Phone: (901) 595-3481
FAX: (901) 595-2381
Education
PhD - Université de Lille, France
Research Interests
- The tumor suppressor pathway Arf/Mdm2/p53 in cancer
- Positive and negative regulation in brain development and cancer
- Genes and microRNAs in brain tumors
- Development of mouse models of human brain cancers to conduct pre-clinical trials with novel targeted therapies
- G1 progression and G1/S control
- Role of the BMP-Atohnal signaling pathway in development and tumorigenesis
Selected Publications
Central Nervous System (CNS)
Ayrault O*, Godeny MD, Dillon C, Zindy F, Fitzgerald P, Roussel MF, Beere H. Inhibition of Hsp90 via 17-DMAG Induces Apoptosis in a p53-Dependent Manner to Prevent Medulloblastoma. Proc Natl Acad Sci, USA 106:17037-17042, 2009.
Ayrault O*, Zindy F*, Regh J, Sherr CJ, Roussel MF. Two tumor suppressors, p27Kip1 and Patched 1 collaborate to prevent medulloblastoma. Mol Cancer Res Jan;7(1):33-40, 2009.
Uziel T, Karginov FV, Xie S, Parker JS, Wang YD, Gajjar A, He L, Ellison D, Gilbertson RJ, Hannon G, Roussel MF. The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci U S A Feb 24;106(8):2812-7, 2009. Epub 2009 Feb 5.
Reilly KM, Rubin JB, Gilbertson RJ, Garbow JR, Roussel MF, Gutmann DH. Re-thinking Brain Tumors: The Fourth Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop. Meeting Report. Cancer Research 68: 5508-5511, 2008.
Zhao H*, Ayrault A*, Zindy F, Kim J-H, Roussel MF. Post-transcriptional downregulation of Atoh1/Math1 by Bone Morphogenic Proteins Suppresses Medulloblastoma Development. Genes Dev 22:160; 722-727, 2008.
Martins RA, Zindy F, Donovan S, Zhang J, Pounds S, Knoepfler PS, Eisenman RN, Roussel MF, Dyer MA. N-Myc regulates retinal progenitor cell proliferation through p27Kip1. Genes Dev, 22:179-193, 2008.
Zindy F*, Uziel T*, Ayrault O, Calabrese C, Valentine M, Rehg G, Gilbertson R, Sherr CJ, Roussel MF. Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res 67: 2676-2684, 2007.
Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel MF, Segil N, Pivola U. p19Ink4d and p21Cip1 collaborate to maintain the post-mitotic state of auditory hair cells, their co-deletion leading to DNA damage and p53-mediated apoptosis. J Neurosci 27:434-1444, 2007.
Zindy F, Knoepfler P, Xie S, Sherr CJ, Eisenman R, Roussel MF. N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. PNAS 103:11579-11583, 2006.
Gil-Perotin S, Marin-Husstege M, Li J, Soriano-Navarro M, Zindy F, Roussel MF, Garcia-Verdugo JM,Casaccia-Bonnefil P.Loss of p53 induces changes in the behavior of SVZ cells: implication forthe genesis of glial tumors. J Neurosci26: 1107-1116, 2006.
Uziel T, Zindy F, Sherr CJ, Roussel MF. The CDK inhibitor p18Ink4c is a tumor suppressor in medulloblastoma. Extra Views. Cell Cycle 5, 363-365, 2006.
Arf/Mdm2/p53 Tumor Suppressor Pathway
Ayrault O, Zindy F, Roussel MF. TP53 and RB tumor suppressor pathways collaborate in retinoblastoma genesis. Medecine/Sciences. Ed. EDK. 23:356-358, 2007.
Roussel MF. Tumor Suppressors. Chapter 7 in ”Molecular Biology of Cancer”. Editors, Pelengaris and Khan, Blackwell Ltd, pp 219-150, 2006.
Sherr CJ, Bertwistle D, Den Besten W, Kuo ML, Sugimoto M, Tago K, Williams RT, Zindy F, Roussel MF. p53-Dependent and -independent functions of the Arf tumor suppressor. Cold Spring Harbor Laboratories 70, 129-137, 2006.
Williams RT, Roussel MF, Sherr CJ. Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl induced acute lymphoblastic leukemia. Proc Natl Acad Sci USA 103: 6688-93, 2006.
Signaling and G1 progression
Huang DT, Ayrault O, Hunt HW, Taherbhoy AM, Duda DM, Scott DC, Borg LA, Neale G, Murray PJ, Roussel MF, Schulman BA. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell Feb 27;33(4):483-95, 2009.
Forget A, Ayrault O, den Besten W, Kuo M-L, Sherr CJ, Roussel MF. Differential post-transcriptional regulation of two Ink4 proteins, p18Ink4c and p19Ink4d. Cell Cycle Dec;7(23):3737-46, 2008. Epub 2008
Souffron J, Waddell M, Paydar A, Tokgoz Z, Roussel MF, Schulman B. Structural Dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8’s E1. Biochemistry 47: 8961-8969, 2008.
Nilsson LM, Keller UB, Yang C-Y, Nilsson JA, Cleveland JL, Roussel MF. Ink4c is dispensable for tumor suppression in Myc-induced lymphomagenesis. Oncogene 26:2833-2839, 2007.
Last update: February 2010
