Martine F. Roussel, PhD

    Martine F. Roussel, PhD

    Member, St. Jude Faculty
    Endowed Chair in Molecular Oncogenesis
    Co-Leader, Cancer Genetics, Biochemistry and Cell Biology Program
    Professor, Department of Molecular Sciences, UT Memphis
    Vice-President for the US, Eurocancer, Paris, France (2003-present)
    Chair, Erasmus University of Sciences, Paris, VII France and St. Jude Exchange Program, Spring/Summer Laboratory Training for Masters Students

    Departments

    Tumor Cell Biology

    Contact Information

    Martine Roussel, PhD
    Tumor Cell Biology
    MS350, DTRT Room 5006C
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: martine.roussel@stjude.org
    Phone: (901) 595-3481
    FAX: (901) 595-2381

    Education

    PhD - Université de Lille, France


    Honors & Awards


    Research Interests

    Roussel-Sherr Figures 

    Laboratory


    Selected Publications

    Central Nervous System (CNS)

    Zhao M, Gupta V, Raj L, Roussel MF and Bei M. A network of transcription factors operates during tooth morphogenesis. Mol Cell Biol 33:3099-3112, 2013. PMID: 23754753. PMICD: PMC3753897.

    Gebhardt A, Wolf E, Kawauchi D, Walz S, Renninger C, von Eyss B, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M. Miz1 is required to maintain physiological levels of autophagy flux. Nature Communications 2013 (in press).

    Anne SL, Ayrault O, Kim JH, Govek E-E, Van Aelst L, Roussel MF, Hatten M-B. Wnt3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation. PLoS One 2013 (in press).

    Roussel MF, Robinson GW. Role of MYC in Medulloblastoma. Cold Spring Harbor Lab Perspect Med. DOI: 10.1101/CSHPERSPECT/014308. 2013 (in press).

    Vrijens K, Lin W, Cui J, Farmer D, Low J, Pronier E, Zheng F-Y, Shelat AA, Guy K, Taylor MR, Chen T, Roussel MF. Identification of small molecule activators of BMP signaling. PLoS One 8: e59045, 2013.

    Northcott PA, Shih DJH, Peacock J, Garzia L, Morrissy AS, Zichner T, Stutz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FMG, Wang X, Remke M, Wu XC, Chiu RYB, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li YS, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AGJ, Thiessen N, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DTW, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fevre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EMC, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognar L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR. Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PHB, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJM, Korbel JO, Pfister SM, Marra MA, Taylor MD. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature 488(7409):49-56, 2012.

    Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Becksfort J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. Novel mutations target distinct subgroups of medulloblastoma. Nature 488(7409):43-48, 2012.

    Liu Z, Dearman JA, Cox BC, Walters BJ, Zhang L, Ayrault O, Zindy F, Gan L, Roussel MF, Zuo J. Age-dependent in vivo conversion of mouse cochlear pillar and deiters' cells to immature hair cells by atoh1 ectopic expression. J Neurosci 32(19):6600-10, 2012.

    Kawauchi D, Robinson G, Uziel T, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF. A mouse model of the most aggressive subtype of human medulloblastoma. Cancer Cell 21(2):168-80, 2012.

    Gil-Perotin S, Haines JD, Kaur J, Marin-Husstege M, Spinetta MJ, Kim KH, Duran-Moreno M, Schallert T, Zindy F, Roussel MF, Garcia-Verdugo JM, Casaccia P. Roles of p53 and p27 (Kip1) in the regulation of neurogenesis in the murine adult subventricular zone. Eur J Neurosci 34(7):1040-52, 2011.

    Roussel MF. New concepts in organ site research on medulloblastoma: genetics and genomics. Future Oncol 6(8):1229-1231, 2010.

    Ayrault O, Zhao H, Zindy F, Qu C, Sherr CJ, Roussel MF. Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells. Cancer Res 70:5618-5627, 2010. PMID: 20516124

    Signaling and G1 progression

    Zhang Y, Mu Q, Zhou H, Vrijens K, Roussel MF, Jiang G, Yan B. Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors. Cell Death Dis 3:e308, 2012.

    Huang DT, Ayrault O, Hunt HW, Taherbhoy AM, Duda DM, Scott DC, Borg LA, Neale G, Murray PJ, Roussel MF, Schulman BA. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell Feb 27:33(4):483-95, 2009.

    Souffron J, Waddell M, Paydar A, Tokgoz Z, Roussel MF, Schulman B. Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8’s E1. Biochemistry 47(34):8961-9, 2008.

    Complete list of publications


    Last update: September 2013