Martine F. Roussel, PhD

Martine F. Roussel, PhD

Member, St. Jude Faculty
Endowed Chair in Molecular Oncogenesis
Co-Leader, Cancer Genetics, Biochemistry and Cell Biology Program
Professor, Department of Molecular Sciences, UT Memphis
Vice-President for the US, Eurocancer, Paris, France (2003-present)
Chair, Erasmus University of Sciences, Paris, VII France and St. Jude Exchange Program, Spring/Summer Laboratory Training for Masters Students

Departments

Tumor Cell Biology

Contact Information

Martine Roussel, PhD
Tumor Cell Biology
MS350, DTRT Room 5006C
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: martine.roussel@stjude.org
Phone: (901) 595-3481
FAX: (901) 595-2381

Education

PhD - Université de Lille, France


Honors & Awards


Research Interests

Roussel-Sherr Figures 

Laboratory


Selected Publications

Central Nervous System (CNS)

Zindy F, Kawauchi D, Lee Y, Ayrault O, Ben-Merzoug L, McKinnon PJ, Ventura A, Roussel MF. The miR-17~92 cluster is dispensable during embryogenesis but is required for medulloblastoma development. Biol Open PMID: 24928431. 2014 (in press).

Morfouace M, Shelat A, Jacus M, Freeman BB III, Robinson S, Turner D, Zindy Z, Wang Y-D, Finkelstein D, Bihannic L, Puget S, Ayrault O, Li X-N, Olson JM, Robinson GW, Guy K, Stewart CF, Gajjar A, Roussel MF. Pemetrexed and Gemcitabine as Combination Therapy for the Treatment of Group3 Medulloblastoma. Cancer Cell 25:516-529, 2014. PMID: 24684846.
Can adult cancer drugs beat a childhood brain tumor?  
Adult cancer drugs show promise against an aggressive childhood brain tumor

Murphy BL, Obad S, Bihannic L, Ayrault O, Zindy F, Kauppinen S, Roussel MF. Silencing of the miR-17~92 cluster family by seed-targeting 8-mer LNA-antimiRs inhibits medulloblastoma progression in the brain. Cancer Res 73:7068-7078, 2013. PMID: 24145352. PMCID: PMC3857104.

Roussel MF, Robinson, GW. Role of MYC in Medulloblastoma. Cold Spring Harb Perspect Biol 5, 2013. DOI: 0.1101/CSHPERSPECT/014308. PMID: 24186490.

Anne SL, Ayrault O, Kim JH, Govek E-E, Van Aelst L, Roussel MF, Hatten M-B. Wnt3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation. PLoS One 8:e81769, 2013. PMID: 24303070.

Vrijens K, Lin W, Cui J, Farmer D, Low J, Pronier E, Zheng F-Y, Shelat AA, Guy K, Taylor MR, Chen T, Roussel MF. Identification of small molecule activators of BMP signaling. PLoS One 8: e59045, 2013. PMID: 23527084. PMCID: PMC3602516.

Northcott PA, Shih DJH, Peacock J, Garzia L, Morrissy AS, Zichner T, Stutz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FMG, Wang X, Remke M, Wu XC, Chiu RYB, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li YS, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AGJ, Thiessen N, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DTW, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fevre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EMC, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognar L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR. Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PHB, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJM, Korbel JO, Pfister SM, Marra MA, Taylor MD. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature 488(7409):49-56, 2012.

Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Becksfort J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. Novel mutations target distinct subgroups of medulloblastoma. Nature 488(7409):43-48, 2012.

Liu Z, Dearman JA, Cox BC, Walters BJ, Zhang L, Ayrault O, Zindy F, Gan L, Roussel MF, Zuo J. Age-dependent in vivo conversion of mouse cochlear pillar and deiters' cells to immature hair cells by atoh1 ectopic expression. J Neurosci 32(19):6600-10, 2012.

Kawauchi D, Robinson G, Uziel T, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF. A mouse model of the most aggressive subtype of human medulloblastoma. Cancer Cell 21(2):168-80, 2012.

Gil-Perotin S, Haines JD, Kaur J, Marin-Husstege M, Spinetta MJ, Kim KH, Duran-Moreno M, Schallert T, Zindy F, Roussel MF, Garcia-Verdugo JM, Casaccia P. Roles of p53 and p27 (Kip1) in the regulation of neurogenesis in the murine adult subventricular zone. Eur J Neurosci 34(7):1040-52, 2011.

Roussel MF. New concepts in organ site research on medulloblastoma: genetics and genomics. Future Oncol 6(8):1229-1231, 2010.

Ayrault O, Zhao H, Zindy F, Qu C, Sherr CJ, Roussel MF. Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells. Cancer Res 70:5618-5627, 2010. PMID: 20516124

Signaling and G1 progression

Doherty JR, Nilsson LM, Kuliyev E, Zhu H, Mathew R, Cleveland JL, Mead PE, Roussel MF. Embryonic expression and function of the Xenopus Ink4d cyclin D-dependent kinase inhibitor. Cell & Dev Biol  2014 (in press).

Wolf E, Gebhardt A, Kawauchi D, Walz S. von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M. Miz1 is required to maintain physiological levels of autophagy flux. Nature Communications 4:2535, 2013. PMID: 24088869.

Zhao M, Gupta V, Raj L, Roussel MF and Bei M. A network of transcription factors operates during tooth morphogenesis. Mol Cell Biol 33:3099-3112, 2013. PMID: 23754753. PMICD: PMC3753897.

Zhang Y, Mu Q, Zhou H, Vrijens K, Roussel MF, Jiang G, Yan B. Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors. Cell Death Dis 3:e308, 2012.

Huang DT, Ayrault O, Hunt HW, Taherbhoy AM, Duda DM, Scott DC, Borg LA, Neale G, Murray PJ, Roussel MF, Schulman BA. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell Feb 27:33(4):483-95, 2009.

Souffron J, Waddell M, Paydar A, Tokgoz Z, Roussel MF, Schulman B. Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8’s E1. Biochemistry 47(34):8961-9, 2008.

Complete list of publications


Last update: June 2014