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(St. Jude Reference #)
Minimized Liver Specific Promoter forImproved Gene Expression in Gene Therapy Vectors
|Description||Improving expression levels is a key for making gene therapy work in humans. A liver specific promoter with regulatory regions minimized in size is provided. This promoter can be used to express any gene of interest in a size-constrained environment, such as in a self complementary gene therapy vector system.|
|Granted Patents or Published Applications||U.S. Appln. No. 2008/0153156; pending European application|
|Related Scientific References||Nathwani, A.C. et al., “Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver”, Blood 107(7): 2653-61 (April 1, 2006).|
|Licensing Opportunities||This promoter has been licensed for use in gene therapy vectors to treat hemophilia B. We are currently seeking licensing opportunities for all other uses.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2008