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J. Paul Taylor, MD, PhD

J. Paul Taylor, MD, PhD

Associate Member, St. Jude Faculty

Departments

Developmental Neurobiology

Contact Information

J. Paul Taylor, MD, PhD
Developmental Neurobiology
MS 343, D-4026
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: jpaul.taylor@stjude.org
Phone: (901) 595-6047
FAX: (901) 595-5947

Education

MD - Jefferson Medical College, Philadelphia, Pennsylvania
PhD - Jefferson Medical College, Philadelphia, Pennsylvania
Neurology Residency – Hospital of the University of Pennsylvania
Neurogenetics Fellowship – Neurogenetics Branch, NINDS/NIH


Research Interests

The principal goal of our research is to reduce the morbidity and mortality associated with neurodegenerative disease. Toward this end we:

  • Use in vitro and in vivo modeling to elucidate the molecular basis of neuronal dysfunction and neuronal loss in amyotrophic lateral sclerosis, peripheral neuropathy, frontotemporal dementia, and polyglutamine disease
  • Use the fruit fly Drosophila melanogaster to apply the power of genetics to illuminate the pathogenesis of neurodegeneration
  • Screen small molecules to identify compounds that can be translated to clinical use

Selected Publications

Lloyd T, Taylor JP. Flies that can’t fly: the contribution of Drosophila to understanding neuromuscular disease. Annals of the New York Acad Sci 2009 (in press).

Palazzolo I, Stack C, Kong L, Musaro A, Adachi H, Katsuno M, Sobue G, Taylor JP, Sumner C, Fischbeck KH, Pennuto M. Overexpression of IGF-1 attenuates disease in a mouse model of spinal and bulbar muscular atrophy. Neuron Aug 13;63(3):316-28, 2009.

Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neurons diseases. J Neurosci 29(25):8236-47, 2009.

Salajegheh M, Pinkus JL, Taylor JP, Amato AA, Nazareno R, Baloh RH, Greenberg SA. Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. Muscle and Nerve­ 40(1):19-31, 2009.

Salomons FA, Menendez-Benito V, Bottcher C, McCray BA, Taylor JP, Dantuma NP. Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress. Mol Cell Biol 29(7):1774-1785, 2009.

Young J, Garden G, Martinez R, Tanaka F, Sandoval C, Smith A, Sopher B, Lin A, Fischbeck KH, Taylor JP, La Spada AR. Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. J Neurosci 29(7):1987-1997, 2009.

Taylor JP. Diagnosis and treatment of cerebellar ataxia in adults. In: UpToDate, Basow, DS, UpToDate, Waltham, MA, 2009.

Nedelsky NB, Todd PK, Taylor JP. Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta 1782(12), 691-699, 2009.

Klionsky DJ, et al. Guidelines for monitoring autophagy in higher eukaryotes. Autophagy 4(2), 151-175, 2008.

McCray B, Taylor JP. The role of autophagy in age-related neurodegeneration. NeuroSignals 16(1), 75-84, 2008.

Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system, and neurodegeneration. Autophagy 3(6), 643-645, 2007.

*Pandey UB, Nie ZP, Batlevi Y, McCray BA, Ritson GP, Schwartz SL, DiProspero N, Knight M, Schuldiner O, Padmanabhan R, Hild M, Berry D, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the ubiquitin-proteasome system. Nature 447, 859-863, 2007. 
*Previewed in Neuron 54, 854-856, 2007 and highlighted as a “Must Read” article by Faculty of 1000

Di Prospero NA, Sumner CJ, Penzak SR, Ravina B, Fischbeck KH, Taylor JP. Safety, tolerability, and pharmacokinetics of high-dose idebenone inpatients with Friedreich’s ataxia. Archives of Neurology 64, 803-8, 2007.

Guinto, JB, Ritson GP, Taylor JP, Forman MS. Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy Acta Neuropath 114(1):55-61, 2007.

Neumann M, Mackenzie MD, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 66, 152-7, 2007.

Subramony SH, May W, Lynch DR, Gomez C, Fischbeck KH, Hallett M, Taylor JP, Wilson RL, Ashizawa T, and the Cooperative Ataxia Group. Measuring Friedreich’s ataxia: inter-rater reliability of a neurologic rating scale. Neurology 64, 1261-1263.

Zeng X-C, Bhasin S, Wu X, Lee J-G, Maffi S, Nichols CJ, Taylor JP, Greene LE, Eisenberg E. Hsp70 dynamics in vivo: effect of heat shock and protein aggregation. J Cell Sci 117(21), 4991-5000, 2004.

Piccioni F, Romano B, Fischbeck KH, Taylor JP. A screen for drugs that protect against the toxicity of polyglutamine-expanded androgen receptor. Hum Molec Genet 13(4), 437-446, 2004.

Sumner CJ, Huynh T, Markowitz JA, Coovert DD, Schussler K, Jarecki J, Burghes AHM, Taylor JP. Fischbeck KH. Valproic acid increases SMN levels in spinal muscular atrophy patient cells. Ann Neurol 54(5), 647-654, 2003.

Taylor JP, Taye AA, Campbell C, Kazemi-Esfarjani P, Fischbeck KH, Min KT.  Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev 17, 1463-1468, 2003.

Taylor JP, Tanaka F, Robitschek J, Markovic-Plese S, Taye AA, Sandoval CM, Fischbeck KH. Aggresomes protect cells by accelerating the degradation of polyglutamine-containing protein. Hum Molec Genet 12(7), 749-757, 2003.

La Spada AR, Taylor JP. Polyglutamines placed into context. Neuron 38, 681-684, 2003.

Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease.  Science 296(5575), 1991-1995, 2002.

Taylor JP, Galetta SL, Asbury AK, Volpe NJ. Hemolytic anemia presenting as idiopathic intracranial hypertension.  Neurology 59, 960-961, 2002.

Caplen NJ, Taylor JP, Statham VS, Tanaka F, Fire A, Morgan RA. Rescue of polyglutamine toxicity by dsRNA-mediated RNA interference in Drosophila and mammalian cells. Hum Molec Genet 11, 175-184, 2002.

Taylor JP, Fischbeck KH. Altered acetylation in polyglutamine disease: an opportunity for therapeutic intervention? Trends Mol Med 8(5), 195-197, 2002.

Taylor JP, Sater R, French J, Baltuch G, Crino PB. Transcription of intermediate filament genes is enhanced in focal cortical dysplasia. Acta Neuropath 102(2), 141-148, 2001.

McCampbell A, Taylor JP, Taye AA, Robitschek JB, Li M, Walcott J, Merry D, Chai Y, Paulson H, Sobue G, Fischbeck KH. CBP sequestration by expanded polyglutamine. Hum Molec Genet 9(14), 2197-2202, 2000.

Taylor JP, Pomerantz RJ, Oakes JW, Khalili K, Amini SA. A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 Tat. Oncogene 10(2), 395-400, 1995.

Taylor JP, Pomerantz RJ, Raj G, Kashanchi F, Brady J, Amini S, Khalili K. CNS-derived cells express a kappa B-binding activity that enhances HIV-1 transcription in vitro and facilitates TAR-independent transactivation by Tat. J Virol 68, 3971-3981, 1994.

Duan L, Ozaki I, Oakes JW, Taylor JP, Khalili K, Pomerantz RJ. The tumor suppressor protein p53 strongly alters HIV-1 replication. J Virol 68, 4302-4313, 1994.

Taylor JP, Khalili K. Activation of HIV-1 transcription by Tat in cells derived from the CNS – evidence for the participation of NF-kB – a review.  In: Advances in Neuroimmunology, edited by Roberta Black, New York Academy of Sciences. Vol. 4, 291-303, 1994.

Cupp C, Taylor JP, Khalili K, Amini S. Evidence for stimulation of the TGF- promoter by HIV-1 Tat in cells derived from the CNS. Oncogene 8, 2231-2236, 1993.

Taylor JP, Kundu M, Khalili K. Tar-independent activation of HIV-1 requires the activation domain but not the RNA-binding domain of Tat. Virology 195, 780-785, 1993.

Bagasra O, Khalili K, Seshamma T, Taylor JP, Pomerantz RJ. TAR-independent replication of HIV-1 in glial cells.  J Virol  66, 7522-7528, 1992.

Chowdhury M, Taylor JP, Chang CF, Rappaport J, Khalili K. Evidence that a sequence similar to TAR is important for induction of the JC virus late promoter by human immunodeficiency virus type 1 Tat. J Virol 66, 7355-7361, 1992.

Taylor JP, Cupp C, Diaz A, Jimenez S, Khalili K, Amini S. Activation of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells. Proc Natl Acad Sci USA 89, 9617-9621, 1992.

Taylor JP, Pomerantz RJ, Bagasra O, Chowdhury M, Rappaport J, Khalili K, Amini S. TAR-independent transactivation by Tat in cells derived from the CNS - a novel mechanism of HIV-1 gene regulation. EMBO J 11, 3395-3403, 1992.

Chowdhury M, Taylor JP, Tada H, Rappaport J, Wong-Staal F, Amini S, Khalili K. Regulation of the human neurotropic virus promoter by JCV T antigen and HIV-1 Tat protein. Oncogene 5, 1737-1742, 1990.

Last update: October 2009

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