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St. Jude investigators have mapped out many of the dynamic genetic and biochemical changes that make up a cell's response to a shortage of a molecule called Coenzyme A (CoA), a key player in metabolism.
St. Jude uses computer-generated images of different types of same enzyme to unlock mysteries of antibiotic resistance and a rare form of brain degeneration.
The mechanism that folds proteins into their proper shapes also increases the cell's capacity for folding and shipping proteins. This allows efficient protein folding and packaging, which must occur thousands of times a minute in response to infections.