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Associate Member, St. Jude Faculty
Paul Thomas, PhD
MS 351, Room E7060
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-6507
FAX: (901) 595-3107
BS – Wake Forest University, Winston-Salem, North Carolina (1999)
PhD – Harvard University, Cambridge, Massachusetts (2003)
Cukalac T, Chadderton J, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL Reproducible selection of high acidity CD8(+) T-cell clones following secondary acute virus infection. Proc Natl Acad Sci USA 111(4):1485-1490, 2014.
Rudraraju R, Sealy RE, Surman SL, Thomas PG, Dayton BH, Hurwitz JL. Non-random lymphocyte distribution among virus-infected cells of the respiratory tract. Viral Immunol 26(6):378-384, 2013.
Rutigliano JA, Sharma S, Morris MY, Oguin TH 3rd, McClaren JL, Doherty PC, Thomas PG. Highly pathologic influenza A virus infection is associated with augmented expression of PD-1 by functionally-compromised virus-specific CD8+ T cells. J Virol November 20, 2013.
Sharma S, Thomas PG. The two faces of heterologous immunity: protection or immunopathology. J Leukoc Biol November 8, 2013.
Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, Brown SA, Surman S, Wilson ZS, Bradley P, Hurwitz J, Chi H, Doherty PC, Thomas PG, McGargill MA. The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol October 20, 2013.
Askovich PS, Sanders CJ, Rosenberger CM, Diercks AH, Dash P, Navarro G, Vogel P, Doherty PC, Thomas PG, Aderem A. Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses PLoS One 8(9):e74863, 2013.
La Gruta NL, Thomas PG. Interrogating the relationship between naive and immune antiviral T cell repertoires. Curr Opin Virol 3(4):447-51, 2013.
Tam VC, Quehenberger O, Oshansky CM, Suen R, Armando AM, Treuting PM, Thomas PG, Dennis EA, Aderem A. Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation. Cell 154(1):213-27, 2013.
Ghoneim HE, Thomas PG, McCullers JA. Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections. J Immunol June 26, 2013.
Sanders CJ, Vogel P, McClaren JL, Bajracharya R, Doherty PC, Thomas PG. Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels. Am J Physiol Lung Cell Mol Physiol 304(7):L481-L488, 2013.
O'Reilly MC, Scott SA, Brown KA, Oguin TH, Thomas PG, Daniels JS, Morrison R, Brown HA, Lindsley CW. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J Med Chem 56(6):2695-9, 2013.
Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol March 24, 2013.
Thomas PG, Handel A, Doherty PC, La Gruta NL. Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations. Proc Natl Acad Sci U S A January 14, 2013.
Sanders CJ, Johnson B, Frevert CW, Thomas PG. Intranasal influenza infection of mice and methods to evaluate progression and outcome. Methods Mol Biol 1031:177-88, 2013.
Thomas PG, Hertz T. Constrained evolution drives limited influenza diversity. BMC Biol 10(43), 2012.
Wang GC, Dash P, McCullers JA, Doherty PC, Thomas PG. T cell receptor alpha beta diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection. Sci Transl Med 4(128):128ra42, 2012.
Van Stry M, Oguin T, Cheloufi S, Vogel P, Watanabe M, Pillai MR, Dash P, Thomas P, Hannon GJ, Bix M. Enhanced susceptibility to influenza A virus of Ago1/3 double null mice. J Virol 86(8):1451-7, 2012.
Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polic B, Al-Harthi L, Sperling AI, Guevara-Patino JA. NKG2D signaling on CD8(+) T cells represses T-bet and rescues CD4-unhelped CD8(+) T cell memory recall but not effector responses. Nat Med 18(3):422-8, 2012.
Doherty PC, Thomas PG. Dangerous for ferrets: lethal for humans? BMC Biol 10:10, 2012.
Oshansky CM, Thomas PG. The human side of influenza. J Leukoc Biol 2012.
Ruckwardt TJ, Malloy AMW, Gostick E, Price DA, Dash P, McClaren JL, Thomas PG, Graham BS. Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected mice. PLoS Pathog 7(12):2377, 2011.
Sharma S, Sundararajan A, Suryawanshi A, Kumar N, Veiga-Parga T, Kuchroo VK, Thomas PG, Sangster MY, Rouse BT. T cell immunoglobulin and mucin protein-3 (Tim-3)/galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses. Proc Natl Acad Sci U S A 108(47):19001-6, 2011.
Moon JJ, Dash P, Oguin TH, McClaren JL, Chu HH, Thomas PG, Jenkins MK. Quantitative impact of thymic selection on Foxp3(+) and Foxp3(-) subsets of self-peptide/MHC class II-specific CD4(+) T cells. Proc Natl Acad Sci U S A 108(35):14602-7, 2011.
Surman SL, Rudraraju R, Woodland DL, Dash P, Thomas PG, Hurwitz JL. Clonally related CD8 T cells responsible for rapid population of both diffuse nasal-associated lymphoid tissue and lung after respiratory virus infection. J Immunol June 20, 2011.
Billam P, Bonaparte KL, Liu J, Ruckwardt TJ, Chen M, Ryder AB, Wang R, Dash P, Thomas PG, Graham BS. T cell receptor clonotype influences epitope hierarchy in the CD8 T cell response to respiratory syncytial virus infection. J Biol Chem 286(6):4829-41, 2011.
Dash P, McClaren JL, Oguin TH, Rothwell W, Todd B, Morris MY, Becksfort J, Reynolds C, Brown SA, Doherty PC, Thomas PG. Paired analysis of TCR[alpha] and TCR[beta] chains at the single-cell level in mice. J Clin Invest 121(1):288-295, 2011.
Rawlings JS, Gatzka M, Thomas PG, Ihle JN. Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence. EMBO J December 17, 2010.
Moffat JM, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL. Influenza epitope-specific CD8( ) T cell avidity, but not cytokine polyfunctionality, can be determined by TCR beta clonotype. J Immunol 185(11):6850-6856, 2010.
Ellebedy AH, Fabrizio T, Kayali G, Oguin T, Brown S, Rehg J, Thomas P, Webby RJ. Contemporary seasonal A (H1N1) influenza virus infection primes for a more robust response to split inactivated pandemic A(H1N1) vaccination in ferrets. Clin Vaccine Immunol October 20, 2010.
Sanders CJ, Doherty PC, Thomas PG. Respiratory epithelial cells in innate immunity to influenza virus infection. Cell Tissue Res September 17, 2010.
Last updated: July 2014