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Research
Associate Member, St. Jude Faculty
Director, High Throughput Screening Center
Chemical Biology & Therapeutics
Taosheng Chen, PhD, PMP
Chemical Biology & Therapeutics
MS 1000, Room E9051
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: taosheng.chen@stjude.org
Phone: (901) 595-5937
FAX: (901) 595-5715
PhD - University of Vermont
MS - Fudan University, Shanghai
BS - Fudan University, Shanghai
Wang YM, Lin W, Chai SC, Wu J, Ong SS, Schuetz EG, Chen T. Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1. Toxicol Appl Pharmacol, 2013, May 22. doi:pii: S0041-008X(13)00222-6. doi: 10.1016/j.taap.2013.05.014. [Epub ahead of print].
Yu DD*, Lin W, Chen T* (*co-corresponding author), Forman BM. Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery. Bioorg Med Chem 21: 4266-4278, 2013.
Elias A, Wu J, Chen T. Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity. Mol Pharmacol 83(6): 1229-1236, 2013.
Goktug AN, Chai SC, Chen T. A timetable organizer for the planning and implementation of screenings in manual or semi-automation mode. J Biomol Screen, 2013 May 7. [Epub ahead of print].
Vrijens K, Lin W, Cui J, Farmer D, Low J, Pronier E, Zeng FY, Shelat AA, Guy K, Taylor MR, Chen T, Roussel MF. Identification of small molecule activators of BMP signaling. PLoS ONE 8(3): e59045. doi:10.1371/journal.pone.0059045, 2013.
Liu L, Wu J, Ong SS, Chen T. Cyclin-dependent kinase 4 phosphorylates and positively regulates PAX3-FOXO1 in human alveolar rhabdomyosarcoma cells. PLoS ONE 8(2): e58193. doi: 10.1371/journal.pone.0058193, 2013.
Goktug AN, Chai SC, Chen T. Data analysis approaches in high throughput screening. Drug Discovery, Prof. Hany El-Shemy (Ed.), pp. 201-226. ISBN: 978-953-51-0906-8, InTech, DOI: 10.5772/52508, 2013. [Available from: http://www.intechopen.com/books/drug-discovery/data-analysis-approaches-in-high-throughput-screening]
Chai SC, Goktug AN, Cui J, Low J, Chen T. Practical considerations of liquid handling devices in drug discovery. Drug Discovery, Prof. Hany El-Shemy (Ed.), pp. 177-200. ISBN: 978-953-51-0906-8, InTech, DOI: 10.5772/52546, 2013. [Available from: http://www.intechopen.com/books/drug-discovery/practical-considerations-of-liquid-handling-devices-in-drug-discovery]
Goktug AN, Ong SS, Chen T. GUItars: a GUI tool for analysis of high-throughput RNA interference screening data. PLoS ONE 7(11):e49386, 2012.
Liu L, Chen T. PAX3-FKHR regulates the expression of pleiotrophin to mediate motility in alveolar rhabdomyosarcoma cells. J Can Res Updates 1:49-56, 2012.
Wang YM, Ong SS, Chai SC, Chen T. Role of CAR and PXR in xenobiotic sensing and metabolism. Expert Opin Drug Metab Toxicol May 3, 2012.
Liu L, Wang YD, Wu J, Cui J, Chen T. Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells. BMC Cancer 12(1):154, 2012.
Li G, Lin W, Araya JJ, Chen T, Timmermann BN, Guo GL. A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. Toxicol Appl Pharmacol 258(2):268-274, 2012
Ong SS, Wang Y-M, Chai SC, Chen T. Pregnane X receptor in drug development. In “Drug Development – A Case Study Based Insight into Modern Strategies” (C. Rundfeldt, ed.), pp.337-364. Intech, ISBN 978-953-307-257-9, 2011.
Zhao Y, Hammoudeh D, Lin W, Das S, Yun MK, Li Z, Griffith E, Chen T, White SW, Lee RE. Development of a pterin-based fluorescent probe for screening dihydropteroate synthase. Bioconjug Chem September 30, 2011.
Cui J, Chai SC, Shelat AA, Guy RK, Chen T. An automated approach to efficiently reformat a large collection of compounds. Curr Chem Genomics 5:42-47, 2011.
Bouck DC, Shu P, Cui J, Shelat A, Chen T. A high-content screen identifies inhibitors of nuclear export of forkhead transcription factors. J Biomol Screen 16(4):394-404, 2011.
Ashley JW, McCoy EM, Clements DA, Shi Z, Chen T, Feng X. Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling. Assay Drug Dev Technol 9(1):40-49, 2011.
Pondugula SR, Xie W, Chen T. PXR and hepatocyte proliferation. J Exp Clin Med 2: 260-261, 2010.
Young BM, Hyatt JL, Bouck DC, Chen T, Hanumesh P, Price J, Boyd VA, Potter PM, Webb TR. Structure-activity relationships of substituted 1-Pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors. J Med Chem 53(24):8709-8715, 2010.
Chen T. Overcoming drug resistance by regulating nuclear receptors. Adv Drug Deliv Rev 62:1257-1264, 2010.
Leonardi R, Zhang Y-M, Yun M-K, Zhou R, Zeng F-Y, Lin W, Cui J, Chen T, Rock CO, White SW, Jackowski S. Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain. Chem Biol 17: 892-902, 2010.
Dong H, Lin W, Wu J, Chen T. Flavonoids activate pregnane X receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells. BMC Biochem 11:23, 2010.
Pondugula SR, Tong AA, Wu J, Cui J, Chen T. Protein phosphatase 2C?l regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. Drug Metab Dispos 38: 1411-1416, 2010.
Zeng FY, Dong H, Cui J, Liu L, Chen T. Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochem Biophys Res Commun 391: 1049-1055, 2010.
Herbst J, Anthony M, Stewart J, Connors D, Chen T, Banks M, Petrillo EW, Agler M. Multiplexing a high-throughput liability assay to leverage efficiencies. Assay Drug Dev Technol 7: 294-303, 2009.
Pondugula SR, Dong H, Chen T. Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression. Expert Opin Drug Metab Toxicol 5: 861-873, 2009.
Zeng FY, Cui J, Liu L, Chen T. PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis. Cancer Lett 284: 157-164, 2009.
Mu Q, Du G, Chen T, Zhang B, Yan B. Suppression of human bone morphogenetic protein signaling by carboxylated single-walled carbon nanotubes. ACS Nano 3: 1139-1144, 2009.
Pondugula SR, Brimer-Cline C, Wu J, Schuetz EG, Tyagi RK, Chen T. A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane X receptor. Drug Metab Dispos 37: 719-730, 2009.
Lin W, Wu J, Dong H, Bouck D, Zeng FY, Chen T. Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J Biol Chem 283: 30650-30657, 2008.
Chen T. Nuclear receptor drug discovery. Curr Opin Chem Biol 12: 418-426, 2008.
Agler M, Prack M, Zhu Y, Kolb J, Nowak K, Ryseck R, Shen D, Cvijic ME, Somerville J, Nadler S, Chen T. A high-content glucocorticoid receptor translocation assay for compound mechanism-of-action evaluation. J Biomol Screen 12: 1029-1041, 2007.
Chen T (corresponding author), Knapp AC, Wu Y, Huang J, Lynch JS, Dickson Jr. JK, Lawrence RM, Feyen JHM, Agler M. High throughput screening identified a substituted imidazole as a novel RANK pathway selective osteoclastogenesis inhibitor. Assay Drug Dev Technol 4: 387-396, 2006.
Chen T (co-corresponding author), Feng X. Cell-based assay strategy for identification of motif-specific RANK signaling pathway inhibitors. Assay Drug Dev Technol 4: 473-482, 2006.
Sinz M, Kim S, Zhu Z, Chen T, Anthony M, Dickinson K, Rodrigues AD. Evaluation of 170 Xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions. Curr Drug Metab 7: 375-388, 2006.
Gong H, Sinz M, Feng Y, Chen T, Venkataramanan R, Xie W. Animal models of xenobiotic receptors in drug metabolism and diseases. Methods Enzymol 400: 598-618, 2005.
Chen T (corresponding author), Hansen G, Beske O, Yates K, Zhu Y, Anthony M, Agler M, Banks M. Analysis of cellular events using CellCardTM System in cell-based high-content multiplexed assays. Expert Rev Mol Diagn 5 (5): 817-829, 2005.
Zhu Z, Kim S, Chen T, Lin JH, Bell A, Bryson J, Dubaquie Y, Yan N, Yanchunas J, Xie D, Stoffel R, Sinz M, Dickinson K. Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays. J Biomol Screen 9: 533-540, 2004.
Chen T (corresponding author), Xie W, Agler M, Banks M. Coactivators in assay design for nuclear hormone receptor drug discovery. Assay Drug Dev Technol 6: 835-842, 2003.
Yang XY, Wang L, Mihalic K, Xiao W, Chen T, Li P, Wahl LM, Farrar WL. Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma (PPAR-gamma) activated by macrophage derived 12/15-lipoxygenase ligands. J Biol Chem 277: 3973-3978, 2002.
Chen T (corresponding author). Interleukin-6. In “Encyclopedic Reference of Cancer” (M. Schwab, ed.), pp. 462-464. Springer-Verlag Berlin Heidelberg New York, 2001.
Xiao W, Wang L, Yang XY, Chen T, Hodge D, Johnson PF, Farrar W. CCAAT/enhancer-binding protein beta (CEBP-beta) mediates interferon-gamma-induced P48 (ISGF3-gamma) gene transcription in human monocytic cells. J Biol Chem 276: 23275-23281, 2001.
Chen T (corresponding author), Wang L, Farrar WL. Interleukin-6 activates androgen receptor (AR)-mediated gene expression through a STAT3-dependent pathway in LNCaP prostate cancer cells. Cancer Res 60: 2132-2135, 2000.
Yang XY, Wang L, Chen T, Hodge DR, Resau JH, DaSilva L, Farrar WL. Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists. J Biol Chem 275: 4541-4544, 2000.
Chen T, Cho RW, Stork PJS, Weber MJ. Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase (MAP kinase) by growth factors in LNCaP prostate cancer cells. Cancer Res 59: 213-218, 1999.
Gao Z, Chen T, Weber MJ, Linden J. A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. J Biol Chem 274: 5972-5980, 1999.
Chen T, Kurjan J. Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17: 3429-3439, 1997.
Luo Z, Ma C, Chen T, Guo L, Lin W. History and present status of research on the antineoplastic activity of parvoviruses (Review). J Fudan University (Natural Science) 32: 85-92, 1993.
Luo Z, Chen T, Yan S, Wang S, Liu W, Wang J, Sun J. Protein sequence homology comparison of viral proteins and oncoproteins as an evidence for the lack of oncogenic potency in parvoviruses. J Fudan University (Natural Science) 30: 405-412, 1991.
Guo L, Su ZZ, Luo Z, Chen T, Luan Y, Pu X. Malignant transformation increases the sensitivity of cells to parvoviruses. Chinese J Cell Biol 10: 125-130, 1988.
Last update: March 2013
