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Finding Cures. Saving Children.
Taosheng Chen, PhD, PMP®
Assistant Member, St. Jude Faculty
Director, High Throughput Screening Center
Departments
Chemical Biology & Therapeutics
Contact Information
Taosheng Chen, PhD, PMP
Chemical Biology & Therapeutics
MS 1000, Room E9051
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: taosheng.chen@stjude.org
Phone: (901) 595-5937
FAX: (901) 595-5715
Education
PhD - University of Vermont
MS - Fudan University, Shanghai
BS - Fudan University, Shanghai
Research Interests
- Regulation of PXR signal transduction
- Nuclear hormone receptor signaling and drug resistance
- Regulation of PAX3-FKHR/FOXO1 signaling in rhabdomyosarcoma
- Development of drug discovery technologies
- High throughput screening (HTS) and high content screening (HCS)
Selected Publications
Herbst J, Anthony M, Stewart J, Connors D, Chen T, Banks M, Petrillo EW, Agler M. Multiplexing a high-throughput liability assay to leverage efficiencies. Assay Drug Dev Technol 2009 (in press).
Pondugula SR, Dong H, Chen T. Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression. Expert Opin Drug Metab Toxicol 5(8): 1-13, 2009.
Zeng FY, Cui J, Liu L, Chen T. PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis. Cancer Lett 2009 May 11. [Epub ahead of print]
Mu Q, Du G, Chen T, Zhang B, Yan B. Suppression of human bone morphogenetic protein signaling by carboxylated single-walled carbon nanotubes. ACS Nano 2009 Apr 29. [Epub ahead of print]
Pondugula SR, Brimer-Cline C, Wu J, Schuetz EG, Tyagi RK, Chen T. A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane X receptor. Drug Metab Dispos 37: 719-730, 2009.
Lin W, Wu J, Dong H, Bouck D, Zeng FY, Chen T. Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J Biol Chem 283: 30650-30657, 2008.
Chen T. Nuclear receptor drug discovery. Curr Opin Chem Biol 12: 418-426, 2008.
Agler M, Prack M, Zhu Y, Kolb J, Nowak K, Ryseck R, Shen D, Cvijic ME, Somerville J, Nadler S, Chen T. A high-content glucocorticoid receptor translocation assay for compound mechanism-of-action evaluation. J Biomol Screen 12: 1029-1041, 2007.
Chen T (corresponding author), Knapp AC, Wu Y, Huang J, Lynch JS, Dickson Jr. JK, Lawrence RM, Feyen JHM, Agler M. High throughput screening identified a substituted imidazole as a novel RANK pathway selective osteoclastogenesis inhibitor. Assay Drug Dev Technol 4: 387-396, 2006.
Chen T (co-corresponding author), Feng X. Cell-based assay strategy for identification of motif-specific RANK signaling pathway inhibitors. Assay Drug Dev Technol 4: 473-482, 2006.
Sinz M, Kim S, Zhu Z, Chen T, Anthony M,
Gong H, Sinz M, Feng Y, Chen T, Venkataramanan R, Xie W. Animal models of xenobiotic receptors in drug metabolism and diseases. Methods Enzymol 400: 598-618, 2005.
Chen T (corresponding author), Hansen G, Beske O, Yates K, Zhu Y, Anthony M, Agler M, Banks M. Analysis of cellular events using CellCardTM System in cell-based high-content multiplexed assays. Expert Rev Mol Diagn 5 (5): 817-829, 2005.
Zhu Z, Kim S, Chen T, Lin JH, Bell A, Bryson J, Dubaquie Y, Yan N, Yanchunas J, Xie D, Stoffel R, Sinz M, Dickinson K. Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays. J Biomol Screen 9: 533-540, 2004.
Chen T (corresponding author), Xie W, Agler M, Banks M. Coactivators in assay design for nuclear hormone receptor drug discovery. Assay Drug Dev Technol 6: 835-842, 2003.
Yang XY, Wang L, Mihalic K, Xiao W, Chen T, Li P, Wahl LM, Farrar WL. Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma (PPAR-gamma) activated by macrophage derived 12/15-lipoxygenase ligands. J Biol Chem 277: 3973-3978, 2002.
Chen T (corresponding author). Interleukin-6. In “Encyclopedic Reference of Cancer” (M. Schwab, ed.), pp. 462-464.
Xiao W, Wang L, Yang XY, Chen T, Hodge D, Johnson PF, Farrar W. CCAAT/enhancer-binding protein beta (CEBP-beta) mediates interferon-gamma-induced P48 (ISGF3-gamma) gene transcription in human monocytic cells. J Biol Chem 276: 23275-23281, 2001.
Chen T (corresponding author), Wang L, Farrar WL. Interleukin-6 activates androgen receptor (AR)-mediated gene expression through a STAT3-dependent pathway in LNCaP prostate cancer cells. Cancer Res 60: 2132-2135, 2000.
Yang XY, Wang L, Chen T, Hodge DR, Resau JH, DaSilva L, Farrar WL. Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists. J Biol Chem 275: 4541-4544, 2000.
Chen T, Cho RW, Stork PJS, Weber MJ. Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase (MAP kinase) by growth factors in LNCaP prostate cancer cells. Cancer Res 59: 213-218, 1999.
Gao Z, Chen T, Weber MJ, Linden J. A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. J Biol Chem 274: 5972-5980, 1999.
Chen T, Kurjan J. Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17: 3429-3439, 1997.
Luo Z, Ma C, Chen T, Guo L, Lin W. History and present status of research on the antineoplastic activity of parvoviruses (Review). J
Luo Z, Chen T, Yan S, Wang S, Liu W, Wang J, Sun J. Protein sequence homology comparison of viral proteins and oncoproteins as an evidence for the lack of oncogenic potency in parvoviruses. J
Guo L, Su ZZ, Luo Z, Chen T, Luan Y, Pu X. Malignant transformation increases the sensitivity of cells to parvoviruses. Chinese J Cell Biol 10: 125-130, 1988.
Last update: May 2009
