HAPCORD: Combined Haploidentical and Umbilical Cord Blood Transplantation in Patients with Hematologic Malignancies Using A Reduced Intensity Preparative Regimen


Hematologic Disorders : Hematologic malignancies


The goal of the study is to learn more about the effects (good and bad) of transplanting a partially matched family member (haploidentical) and from a volunteer umbilical cord blood donor. This includes the effects of the radiation, chemotherapy, and the blood cell infusions (haploidentical stem cell infusion and umbilical cord blood stem cell infusion) on the transplant recipient’s engraftment, disease response, and survival.

Donor screening process

Before the stem cell donation begins, some tests are required for what is called a screening process. This screening process will include a physical exam and blood tests to make sure the donor is healthy and able to donate stem cells. The donor will also need to answer questions about their health status (both past and present), immunizations and exposure to any bacteria or viruses. The screening process will tell doctors if the donor is at risk for or has a communicable disease (a disease or infection that can be passed from one person to another).


Primary objective

Secondary objectives

Eligibility criteria, among others, include:



For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).


Mari Dallas, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
FAX: 901-595-4011

Referring or consulting physicians only:

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.