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Research
Member, St. Jude Faculty
Director, High Throughput Chemistry
Chemical Biology & Therapeutics
Thomas Webb, PhD
Chemical Biology & Therapeutics
MS 1000, Room E9057
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: thomas.webb@stjude.org
Phone: (901) 595-3928
FAX: (901) 595-5715
PhD - University of California, Santa Cruz
Baughman BM, Slavish PJ, DuBois RM, Boyd VA, White SW, Webb TR. Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay. ACS Chem Biol 7(3):526-34, 2012.
Fan L, Lagisetti C, Edwards CC, Webb TR, Potter PM. Sudemycins, Novel Small Molecule Analogues of FR901464, induce Alternative Gene Splicing. ACS Chem Biol Mar 7, 2011. (epub) PMID: 21344922
Goronga T, Boyd VA, Lagisetti C, Jeffries C, Webb TR. Radiosynthesis of antitumor spliceosome modulators. Appl Radiat Isot 69(9):1231-1234, 2011. PMID: 21531567
Slavish PJ, Price JE, Jiang Q, Cui X, Morris SW, Webb TR. Synthesis of an Aryloxy Oxo Pyrimidinone Library that Displays ALK-selective Inhibition in an Insulin Receptor Superfamily Kinase Panel. Bioorg Med Chem Lett 21:4592-4596, 2011.
Gundluru MK, Pourpak A, Cui X, Morris SW, Webb TR. Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold. Medchemcomm 2(9):904-908, 2011.
Slavish PJ, Price JE, Jiang Q, Cui X, Morris SW, Webb TR. Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition. Bioorg Med Chem Lett June 12, 2010.
Slavish PJ, Price JE, Hanumesh P, Webb TR. Efficient synthesis of pyrazolopyrimidine libraries. J Comb Chem 12(6):807-809, 2010.
Kasinathan RS, Goronga T, Messerli SM, Webb TR, Greenberg RM. Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel. FASEB J 24 (1): 128-35, 2010. PMCID: PMC2797036
Lagisetti C, Pourpak A, Goronga T, Jiang Q, Cui Xiaoli, Hyle J, Lahti J, Morris S, Webb T. Synthetic mRNA Splicing Modulator Compounds with In Vivo Anti-tumor Activity. J Med Chem 52:6979-6990, 2009.
Boyd VA, Mason J, Hanumesh P, Price J, Russell CJ, Webb TR. 2-Substituted-4,5-Dihydroxypyrimidine-6-Carboxamide Antiviral Targeted Libraries. J Comb Chem 11:1100-1104, 2009.
Aragon AD, Imani RA, Blackburn VR, Cupit PM, Melman SD, Goronga T, Webb TR, Loker ES, Cunningham C. Towards an understanding of the mechanism of action of praziquantel. Mol Biochem Parasitol 164:57-65, 2009.
Webb TR, Slavish J, George RE, Look AT, Xue L, Jiang Q, Cui X, Rentrop WB, Morris SW. Anaplastic Lymphoma Kinsase: role in cancer pathogenesis and small-molecule inhibitor development for therapy. Expert Rev Anticancer Ther 9(3):331-356, 2009.
Slavish PJ, Jiang Q, Cui X, Morris SW, Webb TR. Design and synthesis of a novel tyrosine kinase inhibitor template. Bioorg Med Chem 17(9):3308-3316, 2009. PMCID: PMC2696309
Lee JY, Im I, Webb TR, McGrath D, Song MR, Kim YC. Combinatorial synthesis and biological evaluation of peptide-binding GPCR-targeted library. Bioorg Chem 37(3):90-95, 2009.
George RE, Sanda T, Hanna M, Frohling S, Luther II W, Zhang J, Ahn Y, Zhou W, London WB, McGrady P, Xue L, Zozulya S, Gregor VE, Webb TR, Gray NS, Gilliland DG, Diller L, Greulich H, Morris SW, Myerson M, Look AT. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 455:975-978, 2008. PMCID: PMC2587486
Lagisetti C, Pourpak A, Jiang Q, Cui X, Goronga T, Morris SW, Webb TR. Antitumor Compounds Based on a Natural Product Consensus Pharmacophore: J Med Chem 51:6220-6224, 2008.
Webb TR, Venegas RE, Wang J, Deschenes A. Generation of New Synthetic Scaffolds Using Framework Libraries Selected and Refined via Medicinal Chemist Synthetic Expertise. J Chem Inf Mod 48 (4), 882-888, 2008.
Webb TR, McGrath D, Wang J, Li R, Jiang L, Sviridov S. Application of a Novel Design Paradigm to Generate General Nonpeptide Combinatorial Scaffolds Mimicking Beta Turns: Part II; Synthesis of Agonists of Melanocortin Receptors. J Comb Chem 9, 704-710, 2007.
Zhu T, Yan Z, Chucholowski A, Webb TR, Li R. Polymer-supported Synthesis of Pyridone-focused Libraries as Inhibitors of Anaplastic Lymphoma Kinase. J Comb Chem 8(3), 401, 2006.
Li R*, Xue L, Zhu T, Jiang Q, Cui X, Yan Z, McGee D, Wang J, Gantla V, Pickens JC, McGrath D, Chucholowski A, Morris SW, Webb TR*. Design and Synthesis of 5-Aryl-Pyridone-Carboxamides as Inhibitors of Anaplastic Lymphoma Kinase (ALK). J Med Chem 49:1006-1015, 2006.
Gurova KV, Hill JE, Prokvolit A, Burdelya LG, Guo C, Samoylova E, Khodyakova AV, Ganapathi R, Ganapathi M, Tararova ND, Bosykh D, Lvovsky D, Webb TR, Didonato J, Gudkov AV.* Small molecule, reactivating p53 in renal cell carcinoma, reveals a new NF-κB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci USA 102(48):17448-17453, 2005.
Webb TR*. Current Directions in the Evolution of Compound Libraries. Current Opinion in Drug Discovery and Development 8(3):303-308, 2005.
Chen C, Wilcoxen KM, Huang CQ, Xie Y-F, McCarthy JR, Webb TR, Zhu Y-F, Saunders J, Liu X-J, Chen T-K, Bozigian H, Grigoriadis DE. Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure-Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists. Journal of Medicinal Chemistry 47:4787-4798, 2004.
Webb TR, Moran T, Huang CQ, McCarthy JR, Grigoriadis DE, Chen C. Synthesis of Benzoylpyrimidines as Antagonists of the Corticotropin-releasing Factor-1 Receptor. Bioorganic and Medicinal Chemistry Letters 14(15):3869-73, 2004.
Webb TR*. Some Principles Related to Chemogenomics in Compound Library and Template Design for GPCRs: Book Chapter in H. Kubinyi and G. Müller, 'Chemogenomics in Drug Discovery - A Medicinal Chemistry Perspective.' Methods and Principles in Medicinal Chemistry, published by Wiley-VCH, 2004.
Im I, Webb TR, Gong Y-D, Kim JI, Kim Y-C*. Solid-Phase Synthesis of Tetrahydro-1,4-benzodiazepine-2-one Derivatives as a &Turn Peptidomimic Library. J Comb Chem 6(2):207-213, 2004.
Khasanov AB*, Ramirez-Weinhouse MM, Webb TR, Thiruvazhi M*. Novel Asymmetric Approach to Proline-Derived Spiro-ß-lactams. J Org Chem 69:5766-5769, 2004.
Chianelli D, Kim Y-C, Lvovskiy D, Webb TR*. Application of a Novel Design Paradigm to Generate General Nonpeptide Combinatorial Scaffolds Mimicking Beta Turns: Synthesis of Ligands for Somatostatin Receptors. Bioorganic and Medicinal Chemistry 11(23):5059-5068, 2003.
Huang CQ, Wilcoxen K, McCarthy JR, Haddach M, Webb TR, Gu J, Xie Y-F, Grigoriadis DE, Chen C*. Synthesis and SAR of 8-arylquinolines as potent corticotrophin-releasing factor1 (CRF1) receptor antagonists. Bioorganic and Medicinal Chemistry Letters 13:3375-3379, 2003.
Webb TR*, Lvovskiy D, Kim S-A, Ji X, Melman N, Linden J, Jacobson KA*. Quinazolines As Adenosine Receptor Antagonists: SAR and Selectivity for A2B Receptors. Bioorganic and Medicinal Chemistry 11(1):77-85, 2003.
Webb TR*, Melman N, Lvovskiy D, Ji X, Jacobson KA*. The Utilization of a Unified Pharmacophore Query in the Discovery of New Antagonists of the Adenosine Receptor Family. Bioorganic and Medicinal Chemistry Letters 10(1):31-34, 2000.
Whitten JP*, Xie Y-F, Erickson PE, Webb TR*, Souza EB, Grigoriadis DE, McCarthy JR. Rapid Microscale Synthesis, A New Method for Lead Optimization Using Robotics and Solution Phase Chemistry: Application to the Synthesis and Optimization of Corticotropin Releasing Factor 1 Receptor Antagonists. Journal of Medicinal Chemistry 39:4354-4357, 1996.
Chen C*, Dagnino R, De Souza EB, Grigoriadis DE, Huang CQ, Kim K, Liu Z, Moran T, Webb TR, Whitten J, Zie YF, McCarthy JR*. Design and Synthesis of a Series of Non-Peptide High-Affinity Human Corticotropin-Releasing Factor-1 Receptor Antagonists. Journal of Medicinal Chemistry 39:4358-4360, 1996.
McDowell RS, Gadek TR, Barker PL, Burdick DJ, Chan KS, Quan CL, Skelton N, Struble M, Thorsett ED, Tischler M, Tom JYK, Webb TR, Bumier JP. From Peptide to Non-Peptide. The Elucidation of a Bioactive Conformation of the Arginine-Glycine-Aspartic Acid Recognition Sequence. Journal of American Chemical Society 116: 5069-5076, 1994.
Dagnino R, Webb TR*. Improved Synthesis of Arginine Peptide Aldehydes. Tetrahedron Letters 35:2125-2128, 1994.
Murphy AM, Dagnino Jr R, Vallar PL, Trippe AJ, Sherman SL, Lumpkin RH, Tamura SY, Webb TR*. The Automated Synthesis of Peptide C-Terminal Aldehydes. The Journal of the American Chemical Society 114:3156-3159, 1992.
Webb TR*, Eigenbrot C. Conformationally Restricted Arginine Analogs. Journal of Organic Chemistry 56:3009-3016, 1991.
Rawson TE, Webb TR*. The Synthesis of 5'-Homo-2'-Deoxycytidine. Nucleosides and Nucleotides 9:89-96, 1990.
Webb TR. The Direct Conversion of 5’-0-Trityl-3’-Keto-2’-Deoxythymidine to 1-(2-Deoxy-3-Methyl-Beta-D-Xylosyl)Thymine. Tetrahedron Letters 29, 3769, 1988.
Webb TR*, Mitsuya H, Broder S. 1-(2,3-Anhydro-ß,D-lyxofuranosyl) Cytosine Derivatives as Potential Inhibitors of the Human Immunodeficiency Virus. Journal of Medicinal Chemistry 31, 1475, 1988.
Last update: April 2012
