Non-Therapeutic Protocol

CaRMA: Catheter Resistance Monitoring to Predict Catheter-Associated Adverse Events in Children and Adolescents (CaRMA): A Feasibility Study

Type of Protocol/Clinical Study

Associated Infectious Diseases Studies


Young people with cancer require intravenous (IV) treatment using long-term ‘central-lines’ for medication, and laboratory tests. Central-lines can develop blockages (occlusion) and cause infections or clots in blood vessels. If partial occlusion can be recognized, preventive treatment might prevent these complications.

To find out if weekly central-line resistance monitoring (CRM) can identify partial occlusion, 35 St. Jude patients will have weekly CRM for 12 weeks. CRM results in participants who develop occlusion, infection or clots will be compared with those who do not.

If the study finds that CRM is practical, further research could use this technique to try to prevent problems before they occur.



Principal Investigator

Joshua Wolf, MBBS

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.