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Richard A. Ashmun, PhD

Richard A. Ashmun, PhD

Associate Member, St. Jude Faculty
Director, Flow Cytometry and Cell Sorting Shared Resource

Departments

Tumor Cell Biology
Oncology

Contact Information

Richard Ashmun, PhD
Oncology
MS 350, Room DP030
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: richard.ashmun@stjude.org
Phone: (901) 595-3511
FAX: (901) 595-2381

Education

PhD - University of Michigan, Ann Arbor, Michigan
MSE - University of Michigan, Ann Arbor, Michigan


Research Interests


Selected Publications

Wagner LM, Guichard SM, Burger RA, Straign CM, Ashmun RA, Harris LC, Houghton PJ, Wierdl M, Potter PM, Danks MK.  Targeting gene therapy: application to purging autologous stem cell grafts. Cancer Res 62:5001-5007, 2002.

Gidding CEM, Germain GS, Dilling MB, Meeuwsen-de Boer TGJ, Ashmun RA, de Graaf SSN, Veverka KA, Kamps WA, Houghton PJ. The influence of recombinant human insulin-like graowth factor-1 (rhIGF-1) on cell growth and cytotoxicity of drugs in childhood rhabdomyosarcoma cell lines and xenograft models. Cancer Chemo Pharm 45:21-30, 2000.

Pasqualini R, Koivunen E, Kain R, Lahderanta J, Sakamoto M, Stryhn A, Ashmun RA, Shapiro LH, Arap W, Ruoslahti E. Aminopeptidase N (CD13) is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res 60:722-727, 2000.

McKenzie PP, Guichard S, Middlemas DS, Ashmun RA, Danks MK, Harris LC. Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated. Clin Cancer Res 5:4199-4207, 1999.

Hegde SP, Zhao JF, Ashmun RA, Shapiro LH. c-maf induces monocytic differentiation and apoptosis in bipotent myeloid progenitors. Blood 94:1578-87, 1999.

Persons DA, Allay JA, Allay ER, Ashmun RA, Orlic D, Cunningham JM, Nienhuis AW. Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis. Blood 93:488‑99, 1999.

Hosoi H, Dilling MB, Shikata T, Liu LN, Shu L, Ashmun RA, Germain GS, Abraham RT, Houghton PJ. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res 59:886-894, 1999.

Allay JA, Persons DA, Galipeau J, Riberdy JM, Ashmun RA, Blakley RL, Sorrentino BP. In vivo selection of retrovirally transduced hematopoietic stem cells. Nature Med 4:1136-1143, 1999.

Sexl V, Diehl JA, Sherr CJ, Ashmun R, Beach D, Roussel MF. A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene 18:573‑82, 1999.

Altura RA, Inukai T, Ashmun RA, Zambetti GP, Roussel MF, Look AT. The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells. Blood 92(4):1397-1405, 1998.

Davis JN, Rock CO, Cheng M, Watson JB, Ashmun RA, Kirk H, Kay RJ, Roussel MF. Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase. Mol Cell Biol 17:7398-406, 1997.

Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91: 649-59, 1997.

Persons DA, Allay JA, Allay ER, Smeyne RJ, Ashmun RA, Sorrentino BP, Nienhuis AW. Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. Blood 90:1777-86, 1997.

Quelle DE, Cheng M, Ashmun RA, Sherr CJ. Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF. Proc Natl Acad Sci USA 94:669-73, 1997.

Inaba T, Inukai T, Yoshihara T, Seyschab H, Ashmun RA, Canman CE, Laken SJ, Kastan MB, Look AT. Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. Nature 382:541-4, 1996.

Marathi UK, Howell SR, Ashmun RA, Brent TP. The Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells. Blood 88:2298-305, 1996.

Mathew P, Look T, Luo X, Ashmun R, Nash M, Gajjar A, Walter A, Kun L, Heideman RL. DNA index of glial tumors in children. Correlation with tumor grade and prognosis. Cancer 78:881-6, 1996.

Packham G, Ashmun RA, Cleveland JL. Cytokines suppress apoptosis independent of increases in reactive oxygen levels. J Immunol 156:2792-800, 1996.

Roussel MF, Ashmun RA, Sherr CJ, Eisenman RN, Ayer DE. Inhibition of cell proliferation by the Mad1 transcriptional repressor. Mol Cell Biol 16:2796-801, 1996.

Last update: February 2013