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St. Jude Children’s Research Hospital analysis reveals how the protein p53, which triggers cancer cells to commit suicide, attaches to its regulatory molecule; findings could lead to drugs to unleash p53 to battle a range of cancers. (Richard Kriwacki, PhD, and Douglas Green, PhD)
The p53 protein plays an immensely important role in protecting the body from cancer. Dubbed the cell’s guardian of the genome, p53 is constantly poised to detect potentially tumor-causing DNA damage.
The secret to the ability of a molecule critical for cell division to throw off the protein yoke that restrains its activity is the yoke itself--a disorderly molecule that seems to have a mind of its own.
St. Jude technique for producing cell extracts will help lead to studies of the roles these molecules play in both normal functions and in disease.
The disruption of a molecular bridge that holds together the molecule p53 tends to destabilize this protein, allowing it to form potentially disease-causing aggregates, or "clumps."
Scientists at St. Jude have discovered that the structure of a protein on the surface of pneumonia bacteria helps these germs invade the human bloodstream, which may lead to a more effective pneumonia vaccine.
St. Jude investigators have demonstrated for the first time that many proteins exploit disorderliness in their structure to perform various jobs.
Why are children in southern Brazil more susceptible to a rare type of cancer than children in other parts of the world? St. Jude researchers and clinicians spend more than a decade unraveling the mystery.