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Howard: Complete List of Publications

Paley MS, Meehan EJ, Rosenberger FE, Howard SC, Harris JM.  Synthesis and characterization of a novel betaine dye: 2,4-dimethyl-6-(2,4,6-triphenyl-N-pyridinio)phenolate. J Organic Chem 1989; 54:3432.

Paley MS, McGi1l RA, Howard SC, Wallace SE, Harris JM. Solvatochromism. A new method for polymer characterization. Macromolecules 1990; 23(21):4557-4564.

Herman M, Glass T, Howard SC.  Case Records of LeBonheur Children's Medical Center: A seventeen month old female with abdominal distension and portal vein gas.  Pediatric Emergency Care 1997; 13(3):237-242.

Willner IR, Uhl MD, Howard SC, Williams EQ, Riely CA, Waters B. Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States. Ann Intern Med 1998; 128(2):111-4.

Howard SC, Gajjar A, Ribeiro RC, Rivera GK, Rubnitz J, Sandlund JT, Harrison PL, de Armendi A, Dahl GV, Pui C-H. Safety of lumbar puncture for children with acute lymphoblastic leukemia and thrombocytopenia.  JAMA 2000; 284(17):2222-2224.

McCarville B, Hoffer FA, Howard SC, Goloubeva O, Kauffman W. Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol 2001; 31:102-105.

Howard SC, Gajjar AJ, Cheng C, Kritchevsky SB, Somes GW, Harrison PL, Ribeiro RC, Rivera GK, Rubnitz JE, Sandlund JT, Armendi AJ de, Razzouk BI, Pui C-H. Traumatic lumbar puncture in pediatric patients with acute lymphoblastic leukemia. JAMA 2002; 288:2001-2007.

Crews K, Wimmer P, Howard SC, Razzouk B. Pharmacokinetics of 2-CDA in a pediatric patient undergoing hemofiltration and hemodialysis for acute renal failure. J Pediatr Hematol Oncol 2002; 24:677-680.

Howard SC, Pui C-H. Endocrinopathy in children with acute lymphoblastic leukemia. Blood Reviews 2002; 16:225-243.

Howard SC, Armendi AJ, Pui C-H. Racial difference in rates of traumatic lumbar puncture (letter). JAMA 2003; 289:548-549.

Howard SC, Kaplan SD, Razzouk BI, Sandlund JT, Ribeiro RC, Gajjar AJ, Skoch JP, Roy III S, Hudson M, Pui C-H. Urolithiasis in pediatric patients with acute lymphoblastic leukemia. Leukemia 2003;17:541-6

Pui C-H, Sandlund JT, Pei D, Rivera GK, Howard SC, Ribeiro RC, Rubnitz JE, Razzouk BI, Hudson M, Cheng C, Raimondi SC, Behm FG, Downing J, Relling MV, Evans WE. Recent improvements in therapy for acute lymphoblastic leukemia extend to black children. JAMA 2003; 290:2001-2007.

Metzger M, Howard SC, Fu LC, Peña A, Stefan R, Hancock ML, Zhang Z, Pui C-H, Wilimas J, Ribeiro RC. Improving the outcome of childhood acute lymphoblastic leukemia in countries with limited resources: insights from Honduras. Lancet 2003; 362:706-708.

Howard SC, Naidu PE, Hu XJ, Jeng MR, Rodriguez-Galindo C, Rieman MD, Wang WC. The natural history of moderate aplastic anemia in children. Pediatr Blood Cancer 2004; 43:545-551.

Howard SC, Pedrosa M, Lins M, Pedrosa A, Pui CH, Ribeiro RC, Pedrosa F. Establishment of a pediatric oncology program and outcomes of childhood acute lymphoblastic leukemia in a resource-poor area. JAMA 2004; 291:2471-2475.

Pui CH, Sandlund JT, Pei D, Campana D, Rivera GK, Ribeiro RC, Rubnitz JE, Razzouk BI, Howard SC, Hudson MM, Cheng C, Kun LE, Raimondi SC, Behm FG, Downing JR, Relling MV, Evans WE. Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St. Jude Children's Research Hospital. Blood 2004; 104:2690-2696.

El Saleeby CM, Howard SC, Hayden R, McCullers JA. Association between tea ingestion and invasive Bacillus cereus infection in children with cancer: a case control study. CID 39:1536-1539; 2004.

Tamburro RF, Gordon PL, D’Apolito JP, Howard SC. Unsafe and violent behavior in commercials aired during televised major sporting events. Pediatrics 2004; 114(6):e694-698.

Hudson MM, Krasin M, Link MP, Donaldson SS, Billups C, Merchant TE, Kun L, Billet AL, Kaste S, Tarbell NJ, Howard S, Friedmann AM, Hurwitz CA, Young JA, Marcus KC, Rai S, Cowan T, Weinstein HJ. Risk-adapted combined modality therapy with VAMP/COP and response-based, involved-field radiation for unfavorable pediatric Hodgkin’s disease. J Clin Oncol 2004; 22:4541-4550.

Hijiya N, Onciu M, Howard SC, Zhang Z, Cheng C, Sandlund JT, Kyzer EP, Behm FG, Pui C-H. Utility of automated counting to determine absolute neutrophil counts and absolute phagocyte counts for pediatric cancer treatment protocols. Cancer 2004; 101(11):2681-2686.

Relling MV, Yang W, Das S, Cook EH, Rosner GL, Neel M, Howard S, Ribeiro R, Sandlund JT, Pui C-H, Kaste SC. Pharmacogenetic risk factors for osteonecrosis of the hip among children with leukemia. J Clin Oncol 2004; 22:3930-3936.

Hijiya N, Metzger ML, Pounds S, Schmidt JE, Razzouk BI, Rubnitz JE, Howard SC, Nunez CA, Pui C-H, Ribeiro RC. Severe cardiopulmonary complications consistent with systemic inflammatory response syndrome caused by leukemia cell lysis in childhood acute myelomonocytic or monocytic leukemia. Pediatr Blood Cancer 2005; 44(1):63-69.

Howard SC, Wilimas JA. Delays in diagnosis and treatment of childhood cancer: Where in the world are they important? Pediatr Blood Cancer 2005; 44:303-304.

Kaste SC, Howard SC, McCarville EB, Krasin MJ, Kogos PG, Hudson MM.  18F-FDG-avid sites mimicking active disease in pediatric Hodgkin’s. Pediatric Radiology 2005; 35:141-154.

Sandlund JT, Howard SC, Hijiya N, Pui C-H, Shenep JL, Adderson EE. Myositis complicating Viridans streptococcal sepsis in childhood leukemia. Pediatr Blood Cancer 2005; 44(3):277-279.

Howard SC, Campana D, Coustan-Smith E, Antillon F, Bonilla M, Fu L, Pui, C-H., Ribeiro RC, Wilimas JA, Lorenzana R. Development of a regional flow cytometry center for diagnosis of childhood leukemia in Central America. Leukemia 2005; 19:323-325.

Antillon F, Baez FL, Barr R, Barrantes Zamorra JC, Fu Carrasco L, Moreno B, Bonilla MM, Tognoni G, Valsecchi MG, Howard S, Ribeiro RC, Masera G. AMOR: A proposed cooperative effort to improve outcomes of childhood cancer in Central America. Pediatr Blood Cancer 2005; 45(2):107-110.

Howard SC, Ribeiro RC, Pui C-H. Strategies to improve outcomes of children with cancer in low-income countries. Eur J Cancer 2005; 41(11):1584-1587.

Krasin MJ, Rai SN, Kun LE, Merchant TE, Metzger ML, Howard SC, Hudson MM Patterns of treatment failure in pediatric and young adult patients with Hodgkin's disease: local disease control with combined-modality therapy. J Clin Oncol 2005; 23(33):8406-13.

Rech A, de Carvalho GP, Meneses CF, Hankins J, Howard S, Brunetto AL. The influence of traumatic lumbar puncture and timing of intrathecal therapy on outcome of pediatric acute lymphoblastic leukemia. Pediatr Hematol Oncol 2005; 22(6):483-488.

Hijiya N, Liu W, Sandlund JT, Jeha S, Razzouk BI, Ribeiro RC, Rubnitz JE, Howard SC, Kyzer EP, Redd DS, Cheng C, Rivera GK, Hudson MM, Relling MV, Pui C-H. Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: Lack of therapeutic role of local irradiation. Leukemia 2005; 19(8):1399-403.

Pui C-H, Pei D, Sandlund JT, Campana D, Ribeiro RC, Razzouk BI, Rubnitz JE, Howard SC, Hijiya N, Jeha S, Cheng C, Downing JR, Evans WE, Relling MV, Hudson M. Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia. J Clin Oncol 2005; 23(31):7936-41.

Sanders RP, Maddirala SD, Geiger TL, Pounds S, Sandlund JT, Ribeiro RC, Pui C-H, Howard SC. Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children. Br J Haematol 2005; 130(5):781-787.

Quintana Y, Howard S, Norland M, Patel A, O'Brien R, Ribeiro R. Pond4Kids - a multi-site online Pediatric Oncology Research Database for collaborative protocol research. AMIA Annu Symp Proc. 2005; 1090.

Metzger ML, Howard SC, Hudson MM, Gow KW, Li C-S, Krasin MJ, Merchant T, Kun L, Shelso J,  Pui C-H, Shochat SJ, McCarville MB. Natural history of thyroid nodules in survivors of pediatric Hodgkin lymphoma. Pediatr Blood Cancer 2006; 46(3):314-319.

Reddick WE, Shan ZY, Glass JO, Helton S, Xiong X, Wu S, Bonner MJ, Howard SC, Christensen R, Khan RB, Pui C-H, Mulhern RK. Smaller white matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia. Cancer 2006; 106(4):941-9. PMCID: PMC2396784

Bachir H, Mot S, Metzger ML, Howard SC, Kaste S, Krasin MP, Hudson MM. Itraconazole-enhanced chemotherapy toxicity in a patient with Hodgkin lymphoma. J Pediatr Hematol Oncol 2006; 28(1):33-35.

Hendrick JM, Kaste SC, Tamburro RF, Hoffer FA, Onciu M, Sandlund JT, Ribeiro RC, Chandler JC, Howard SC. Abdominal compartment syndrome in a newly diagnosed patient with Burkitt lymphoma. Pediatr Radiol 2006; 36(3):254-257.

Karimova EJ, Rai SN, Ingle D, Ralph AC, Deng X, Neel MD, Howard SC, Pui CH, Kaste SC. MRI of knee osteonecrosis in children with leukemia and lymphoma: part 2, clinical and imaging patterns. AJR Am J Roentgenol 2006; 186(2):477-82.

Metzger ML, Hudson MM, Somes GW, Shorr RI, Li C-S, Krasin MJ, Shelso J, Pui C-H, Howard SC. White race as a risk factor for hypothyroidism after treatment for pediatric Hodgkin's lymphoma. J Clin Oncol 2006; 24:1516-1521.

Howard SC, Pui C-H. Pitfalls in predicting tumor lysis syndrome. Leuk Lymph 2006 47(5):782-785.

DiSessa TG, Howard SC, Salim MA. Congenital right ventricular diverticulum associated with a ventricular septal defect: a rare echocardiographic finding. Echocardiography 2006; 23(9):787-9.

Caniza M, Clara W, Maron G, Navarro-Marin JE, Rivera R, Howard SC, Camp J, Barfield RC. Establishment of ethical oversight of human research in El Salvador: lessons learned. Lancet Oncol 2006; 7(12):1027-1033

Franklin J, Pluetschow A, Paus M, Specht L, Anselmo A-P, Aviles A, Biti G, Bogatyreva T, Bonadonna G, Brillant C, Cavalieri E, Diehl V, Eghbali H, Fermé C, Henry-Amar M, Hoppe R, Howard S, Meyer R, Niedzwiecki D, Pavlovsky S, Radford J, Raemaekers J, Ryder D, Schiller P, Shakhtarina S, Valagussa P, Wilimas J, Yahalom J. Second malignancy risk associated with treatment for Hodgkin lymphoma: meta-analysis of the randomised trials. Ann Oncol 2006; 17(12):1749-1760.

Hijiya N, Panetta JC, Zhou Y, Kyzer EP, Howard SC, Jeha S, Razzouk BI, Ribeiro RC, Rubnitz JE, Hudson MM, Sandlund JT, Pui C-H, Relling MV. Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia. Blood 2006; 108(13):3997-4002. PMCID: PMC1895448

Jeha S, Behm F, Pei D, Sandlund JT, Ribeiro RC, Razzouk BI, Rubnitz JE, Hijiya N, Howard SC, Cheng C, Pui C-H. Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia. Blood 2006; 108(10):3302-3304. PMCID: PMC1895438

Geiger TL, Howard SC.  Acetaminophen and diphenhydramine premedication for allergic and febrile non-hemolytic transfusion reactions: Good prophylaxis or bad practice? Transfusion Med Rev 2007; 21(2):1-12. PMCID: PMC1868404

Howard SC, Marinoni M, Castillo L, Bonilla M, Tognoni G, Antillon F, Valsecchi MG, Pui C-H, Ribeiro RC, Sala A, Barr RD, Masera G, MISPHO Consortium. Improving outcomes for children with cancer in low income countries in Latin America: A report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO) – PART 1. Pediatr Blood Cancer 2007; 48:364-369.

Howard SC, Ortiz R, Baez F, Cabanas R, Barrantes JC, Fu L, Pena A, Samudio A, Vizcaino M, Rodriguez-Galindo C, Masera G, Barr RD, MISPHO Consortium. Protocol-based treatment for children with cancer in low income countries in Latin America: A report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO) - PART 2. Pediatr Blood Cancer 2007; 48:486-490.

Howard SC, Wilimas JA, Flores A, Pacheco C, de Reyes G, Machin S, Svarch E, Navarrete M, Nieves R, Rodriguez H, Masera G, MISPHO Consortium. Treatment for children with severe aplastic anemia and sickle cell disease in low income countries in Latin America. A report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO): PART III. Pediatr Blood Cancer 2007; 48(5):598-599.

Ayoub L,Fú L, Peña A, Sierra JM, Dominguez PC, Pui C-H, Quintana Y, Rodriguez A, Barr RD, Ribeiro RC, Metzger ML, Wilimas JA, Howard SC. Implementation of a data management program for pediatric cancer units in low-income countries: Tegucigalpa, Honduras. Pediatr Blood Cancer 2007; 49:23-27.

Sanders RB, Geiger TL, Heddle N, Pui C-H, Howard SC. A revised classification scheme for acute transfusion reactions. Transfusion 2007; 47(4):621-628.

Leander C, Fu LC, Peña A, Howard SC, Rodriguez-Galindo C, Wilimas JA, Ribeiro RC, Haik B. Impact of an education program on late diagnosis of retinoblastoma in Honduras. Pediatr Blood Cancer 2007; 49:817-819.

Bachir H, Hudson MM, Kaste SC, Howard SC, Krasin M, Metzger ML. Pericardial involvement at diagnosis in pediatric Hodgkin lymphoma patients. Pediatr Blood Cancer 2007; 49(5):598-599.

Quintana Y, Caniza M, Rivera G, Wilimas J, Rodriguez-Galindo C, Howard S, Ribeiro R. International Consultation Networks for Pediatric Oncology: Results of the Cure4Kids and Consult4Kids Networks, Proceedings of the Information Technology and Communications in Health Conference ITCH 2007, pp. 399-403.

Quintana Y, Howard S, Ribeiro R, Rodriguez A, Ladra M,  Patel A. POND4Kids — An Online Pediatric Hematology/Oncology Database for Collaborative Research, Proceedings of the Information Technology and Communications in Health Conference ITCH 2007, pp. 339-344.

Karimova EJ, Rai SN, Howard SC, Neel M, Britton L, Pui CH, Kaste SC.. Femoral head osteonecrosis in pediatric and young adult patients with leukemia or lymphoma. J Clin Oncol 2007; 25(12):1525-1531.

Hsu S, Metzger ML, Hudson MM, Pedrosa F, Lins M, Barros C, Maciel K, Pui C-H, Ribeiro RC,Howard SC. Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Pediatr Blood Cancer 2007; 49(2):139-144.

Conklin HM, Khan RB, Reddick WE, Helton S, Brown R, Howard SC, Bonner M, Christensen R, Wu S, Xiong X, Mulhern RK. Acute neurocognitive response to methylphenidate among survivors of childhood cancer: a randomized, double-blind, cross-over trial. J Pediatr Psychol 2007; 32(9):1127-1139.

Inaba H, Jenkins JJ, McCarville MB, Morrison RR, Howard SC, Pui C-H, Ribeiro RC. Pulmonary alveolar proteinosis in pediatric leukemia. Pediatr Blood Cancer 2008; 51(1):66-70.

Howard SC, Metzger ML, Wilimas JA, Quintana Y, Pui C-H, Robison LL, Ribeiro RC. Childhood cancer epidemiology in low-income countries. Cancer 2008; 112:461-472.

Pui C-H., Howard SC. Current management and challenges of malignant disease in the CNS in paediatric leukemia. Lancet Oncology 2008; 9(3):257-268.

Marchese VG, Connolly BH, Able C, Booten AR, Bowen P, Porter BM, Rai SN, Hancock ML, Pui C-H, Howard S, Neel MD, Kaste SC. Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescents, and young adults with acute lymphoblastic leukemia. Phys Therapy 2008; 88(3):341-350.

Rubnitz JE, Howard SC, Willis J, Pui C-H, Pounds S, Hayden RT. Baseline mannose binding lectin levels may not predict infection among children with leukemia. Pediatr Blood Cancer 2008; 50(4):866-868.

Martin MB, Li CS, Rowland CC, Howard SC, Kaste SC. Correlation of bone age, dental age, and chronological age in survivors of childhood acute lymphoblastic leukaemia. Int J Paediatr Dentistry 2008; 18(3):217-223.

Roberson JR, Raju S, Shelso J, Pui C-H, Howard SC. Diabetic ketoacidosis during therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2008; 50(6):1207-1212.

Metzger ML, Castellino SM, Hudson MM, Rai SN, Kaste SC, Krasin MJ, Kun LE, Pui C-H, Howard SC. Effect of race on the outcome of pediatric patients with Hodgkin lymphoma. J Clin Oncol 2008; 26(8):1282-1288.

Tamburro RF, Barfield RC, Shaffer ML, Rajasekaran S, Woodard P, Morrison RR, Howard SC, Fiser RT, Schmidt JC, Sillos EM. Changes in outcomes (1996-2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation. Pediatr Crit Care Med 2008; 9(3):270-277.

Hines-Thomas M, Kaste SC, Hudson MM, Howard SC, Liu WA, Wu J, Kun LE, Shulkin BL, Krasin MJ, Metzger ML. Comparison of gallium and PET scans at diagnosis and follow-up of pediatric patients with Hodgkin lymphoma. Pediatr Blood Cancer 2008; 51:198-203.

Ribeiro RC, Steliarova-Foucher E, Magrath I, Lemerle J, Eden T, Forget C, Mortara I, Tabah-Fish I, Divino JJ, Miklavec T, Howard SC, Cavalli F. A descriptive study of the baseline status of pediatric oncology in 10 low- or mid-income countries receiving “My Child Matters” support. Lancet Oncol 2008; 9(8):721-729.

Quintana Y, O’Brien R, Patel A, Becksfort J, Shuler A, Nambayan A, Ogdon D, Chantada G, Howard SC, Ribeiro RC. Cure4Kids: Research challenges in the design of a website for global education and collaboration. Information Design Journal 2008; 16(3):243-249.

Howard SC, Pui C-H, Ribeiro RC. Components of cure: treatment of acute lymphoblastic leukemia in Indonesia and other low-income countries. Pediatr Blood Cancer 2008; 51(6):719-721. NIHMSID: NIHMS123038. PMCID: PMC2746927

Kellie SJ, Howard SC. Global child health priorities: what role for pediatric oncologists? Eur J Cancer 2008; 44(16):2388-96.

Jasper BW, Conklin HM, Lawford J, Morris EB, Howard SC, Wu S, Xiong X, Shelso J, Khan RB. Growth effects of methylphenidate among childhood cancer survivors: a 12-month case-matched open-label study. Pediatr Blood Cancer 2009; 52(1):39-43. PMCID: PMC2585147

Roberson JR, Shelso J, Zhou Y, Inaba H, Metzger ML, Ribeiro RC, Sandlund JT, Jeha S, Pui C-H, Howard SC. Clinical consequences of hyperglycemia during remission induction for pediatric acute lymphoblastic leukemia. Leukaemia 2009; 23(2):245-50. PMID: 18923438. PMCID: PMC2706830

Hunger SP, Sung L, Howard SC. Treatment strategies and regimens of graduated intensity for childhood acute lymphoblastic leukemia in low-income countries: a proposal. Pediatr Blood Cancer 2009; 52:559-565. PMID: 19127567. NIH #123038.

Gupta S, Bonilla M, Fuentes SL, Caniza M, Howard SC, Barr R, Greenberg ML, Ribeiro R, Sung L. Incidence and predictors of treatment related mortality in pediatric acute leukemia in El Salvador. Br J Cancer 2009; 100:1026-1031. PMID: 19293804

Pui C-H, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Coustan-Smith E, Kun LE, Jeha S, Cheng C, Howard SC, Simmons V, Bayles Amy, Metzger ML, Boyett JM, Leung W, Downing JR, Evans WE, Relling MV. Treatment of childhood acute lymphoblastic leukemia without prophylactic cranial irradiation. N Eng J Med 2009; 360:2730-2741. PMID: 19553647. PMCID: PMC2754320

Jayanthan A, Howard SC, Trippett T, Horton T, Whitlock JA, Daisley L, Lewis V, Narendran A. Targeting the Bcl-2 family of proteins in Hodgkin lymphoma: in vitro cytotoxicity, target modulation and drug combination studies of the Bcl-2 homology 3 mimetic ABT-737. Leuk Lymphoma 2009; 50:1174-1182. PMID: 19557638

Conklin HM, Lawford J, Jasper BW, Morris EB, Howard SC, Ogg SW, Wu S, Xiong X, Khan RB. Side effects of methylphenidate in survivors of childhood cancer: a randomized placebo-controlled trial. Pediatrics 2009; 124:226-33. PMID: 19564304

Baskin JL, Pui C-H, Reiss U, Wilimas JA, Metzger ML, Ribeiro RC, Howard SC. Management of central venous catheter occlusions and related complications. Lancet 2009; 374:159-169. PMID: 19595350 NIHMSID: 167173

Jeha S, Pei D, Raimondi SC, Onciu M, Campana D, Cheng C, Sandlund JT, Ribeiro RC, Rubnitz JE, Howard SC, Downing JR, Evans WE, Relling MV, Pui C-H. Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1. Leukemia 2009; 23:1406-9. PMID: 19282835

Bhojwani D, Howard SC, Pui C-H. High risk childhood acute lymphoblastic leukemia. Clinical Myeloma and Leukemia 2009. Clin Lymphoma Myeloma. 2009; 9:S222-S230. PMID: 19778845

Spraker HL, Spyridis G, Pui C-H, Howard SC. Conservative management of pancreatic pseudocysts in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2009; 31(12):957-959.  PMID 19956023

Crews KR, Zhou Y, Pauley J, Howard SC, Jeha S, Relling MV, Pui C-H. Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia. Cancer 2010; 116(1):227-232. PMID: 19834958

Pui C-H, Pei D, Sandlund JT, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Campana D, Kun LE, Jeha S, Cheng C, Howard SC, Metzger ML, Bhojwani D, Downing JR, Evans WE, Relling MV. Long-term results of St. Jude Total Therapy studies 11, 12, 13A, 13B and 14 for childhood acute lymphoblastic leukemia. Leukemia 2010; 24(2):371-382. PMID: 20010620

Morris VK, Reiss U, Howard SC, Spraker HL. Severe thrombocytopenia with iron deficiency anemia. Pediatr Hematol Oncol 2010; 27(5):413-419.  PMID: 20670168

Conklin HM, Khan RB, Reddick WE, Ashford J, Ogg S, Howard SC, Morris EB, Brown R, Bonner M, Christensen R, Wu S, Xiong X, Mulhern RM. Long-term efficacy of methylphenidate in enhancing attention regulation, social skills and academic abilities of childhood cancer survivors. J Clin Oncol 2010; 28(29):4465-72. PMID: 20837955

Metzger ML, Hudson MM, Krasin MJ, Kaste SC, Kun LE, Sandlund JT, Howard SC. Initial response to salvage therapy determines prognosis in relapsed pediatric Hodgkin lymphoma patients. Cancer 2010; 116(18):4376-84. PMID: 20564743

Hines-Thomas M, Howard SC, Hudson MM, Krasin MJ, Kaste SC, Metzger ML. Utility of bone marrow biopsy at diagnosis in pediatric Hodgkin lymphoma. Haematologica 2010; 95(10):1691-6. PMID: 20494933

Bazzeh F, Rihani R, Howard S, Sultan I, Comparing adult and pediatric Hodgkin lymphoma in the Surveillance, Epidemiology and End Results Program, 1988-2005: an analysis of 21,734 cases. Leuk Lymphoma 2010; 51(12):2198-2207. PMID: 21054151

Baker JN, Kane JR, Rai S, Howard SC, Hinds PS, Patient Care Services Research Working Group. Changes in medical care at a pediatric oncology referral center after placement of a do-not-resuscitate order. J Palliative Med 2010; 13(11):1349-1352. PMID: 21034279

Pui C-H. Pei D, Campana D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Coustan-Smith E, Jeha S, Cheng C, Metzger ML, Bhojwani D, Inaba H, Raimondi SC, Onciu M, Howard SC, Leung W, Downing JR, Evans WE, Relling MV. Improved prognosis for older adolescents with acute lymphoblastic leukemia. J Clin Oncol 2011; 29(4): 386-391. PMID: 21172890

Sandlund JT, Pui C-H, Mahmoud MH, Zhou Y, Lowe E, Kaste S, Kun LE, Krasin MJ, Onciu M, Behm FG, Ribeiro RC, Razzouk BI, Howard SC, Metzger ML, Relling MV, Hale GA, Rencher R, Darnell K, Hudson MM. Efficacy of high-dose methotrexate, ifosfamide, etoposide and dexamethasone (MIED) salvage therapy for recurrent or refractory childhood malignant lymphoma. Ann Oncol 2011; 22(2):468-471. PMID: 20624787

Hoffman JM; Baker DK, Howard SC, Laver JH, Shenep JL. Safe and successful implementation of CPOE for chemotherapy at a children’s cancer center. J Natl Compr Canc Netw 2011;9 Suppl 3:S36–S50. PMID: 21357666

Quintana Y, Patel AN, Naidu PE, Howard SC, Antillon FA, Ribeiro RC. POND4Kids: A web-based pediatric cancer database for hospital-based cancer registration and clinical collaboration. Stud Health Technol Inform 2011; 164:227-231. PMID:21335715

Howard SC, Jones DP, Pui C-H. The tumor lysis syndrome. N Eng J Med 2011; 364(19):1844-1854. PMID: 21561350

Kawedia JD, Kaste SC, Pei D, Panetta JC, Cai X, Cheng C, Neale G, Howard SC, Evans WE, Pui C-H, Relling MV. Pharmacokinetic, pharmacodynamic and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia. Blood 2011; 117(8):2340-2347. PMID: 21148812

Brennan RC, Helton KJ, Pei D, Cheng C, Inaba H, Metzger ML, Howard SC, Rubnitz JE, Ribeiro RC, Sandlund JT, Jeha S, Pui C-H, Bhojwani D. Spinal epidural lipomatosis in children with hematologic malignancies. Ann Hematol 2011 Sep; 90(9):1067-74. PMID: 21340722

Howard SC, Jones DP, Pui C-H. The tumor lysis syndrome and hemolysis in a patient with glucose-6-phosphate dehydrogenase deficiency treated with rasburicase. N Eng J Med 2011; 365(6):571-574. PMID: 21830982, 21830981, 21830980 (letters)

Carr S, Allison KJ, Van De Velde LA, Zhang K, English EY, Iverson A, Daw NC, Howard SC, Navid F, Rodriguez-Galindo C, Yang J, Adderson EE, McCullers JA, Flynn PM. Safety and immunogenicity of live attenuated and inactivated influenza vaccines in children with cancer. J Infect Dis 2011 Nov; 204(10):1475-82. PMID: 21949042

Gabus R, Galeano S, de Souza CA, Howard S, Millone JH, Valle ML, Lucero JA, Rosales C, Martinez L, Zarza J, Cauvi F, Borelli G, Prieto M. Hematology in Latin America: where are we? Analysis of the reports of Societies of Hematology associated organization of the Highlights of ASH in Latin America. Rev Bras Hematol Hemoter 2011;33(6):449-54. PMID: 23049362

Krull KR, Khan RB, Ness KK, Ledet D, Zhu L, Pui CH, Howard SC, Srivastava DK, Sabin ND, Hudson MM, Morris EB. Symptoms of attention-deficit/hyperactivity disorder in long-term survivors of childhood leukemia. Pediatr Blood Cancer 2011 Dec 15; 57(7):1191-6. PMID: 21280202

Gupta S, Antillon FA, Bonilla M, Fu L, Howard SC, Ribeiro RC, Sung L. Treatment related mortality in children with acute lymphoblastic leukemia in Central America. Cancer 2011;117(20):4788-95. PMID: 21502627

Day SW, Garcia J, Antillon FA, Wilimas JA, McKeon LM, Carty RM, de Alarcon P, Ribeiro RC, Pui C-H. Howard SC. A sustainable model for pediatric oncology nursing education in low-income countries. Pediatr Blood Cancer 2012 Feb;58(2):163-166. PMID: 22102623

Inaba H, Bhojwani D, Pauley JL, Pei D, Cheng C, Metzger ML, Howard SC, Rubnitz JE, Sandlund JT, Ribeiro RC, Leung W, Campana D, Pui C-H, Jeha S. Combination chemotherapy with clofarabine, cyclophosphamide, and etoposide in children with refractory or relapsed haematological malignancies. Br J Haematol 2012 156(2):275-9. PMID: 21883141

Denburg A, Gupta S, Joffe S, Howard SC, Ribeiro RC, Antillon FA, Vasquez R, Sung L. Pediatric oncology research in low-income countries: Ethical concepts and challenges. Pediatr Blood Cancer 2012 58:492-97. PMID: 22162460

Gonzalez G, Davidoff AM, Howard SC, Pui CH, Rao BN, Shenep JL, Wozniak A, Shochat SJ. Safety of central venous catheter placement at diagnosis of acute lymphoblastic leukemia in children. Pediatr Blood Cancer 2012 58:498-502. PMID: 22162460

Kawedia JD, Liu C, Pei D, Cheng C, Fernandez CA, Howard SC, Campana D, Panetta JC, Bowman WP, Evans WE, Pui CH, Relling MV. Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia. Blood 2012 Feb 16;119(7):1658-64. PMID:22117041

Bhojwani D, Pei D, Sandlund JT, Jeha S, Ribeiro RC, Rubnitz JE, Raimondi SC, Shurtleff S, Onciu M, Cheng C, Coustan-Smith E, Bowman WP, Howard SC, Metzger ML, Inaba H, Leung W, Evans WE, Campana D, Relling MV, Pui C-H. ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy. Leukemia 2012 Aug 26:26(2)265-70. PMID: 21869842

Pui C-H, Pei D, Pappo AS, Howard SC, Cheng C, Sandlund JT, Furman WL, Ribeiro RC, Spunt SL, Rubnitz JE, Jeha S, Hudson MM, Kun LE, Merchant TE, Kocak M, Broniscer A, Metzger ML, Downing JR, Leung W, Evans WE, Gajjar A. Treatment outcomes in black and white children with cancer: Results from the SEER database and St. Jude Children’s Research Hospital, 1992 through 2007. J Clin Oncol 2012; 30(16):2005-12. PMID: 22547602

Baskin JL, Reiss U, Wilimas JA, Metzger ML, Ribeiro RC, Pui C-H, Howard SC. Thrombolytic therapy for central venous catheter occlusion. Haematologica 2012; 97(5):641-650. PMID:22180420

Gupta S, Bonilla M, Valverde P, Fu L, Howard SC, Ribeiro RC, Sung L. Treatment related mortality in children with acute myeloid leukemia in Central America: Incidence, timing and predictors. Eur J Cancer 2012; 48(9):1363-9. PMID: 22082459

Metzger ML, Weinstein HJ, Hudson MM, Billett AL, Larson EC, Friedmann A, Howard SC, Donaldson SS, Krasin MJ, Kun LE, Marcus KJ, Yock TI, Tarbell N, Billups CA, Wu J, Link MP. Results of a prospective clinical trial of VAMP with or without radiation based on early response for children with very low risk Hodgkin lymphoma. JAMA 2012; 307(24):2609-2616. PMID:22735430

Christensen AM, Pauley JL, Molinelli AR, Panetta JC, Ward DA, Stewart CF, Hoffman JM, Howard SC, Pui C-H, Pappo AS, Relling MV, Crews KR. Resumption of high-dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patients. Cancer 2012;118(17):4321-30. PMID: 22252903

Lins MM, Amorim M, Vilela P, Viana M, Ribeiro RC, Pedrosa A, Lucena-Silva N, Howard SC, Pedrosa F. Risk factors for delayed diagnosis of childhood leukemia in Pernambuco, Brazil. Delayed Diagnosis of Leukemia and Association With Morbid-Mortality in Children in Pernambuco, Brazil. J Pediatr Hematol Oncol 2012;34:e271-6 PMID: 22935656

Hicks JK, Crews KR, Hoffman JM, Kornegay NM, Wilkinson MR, Lorier R, Stoddard A, Yang W, Smith C, Fernandez CA, Cross SJ, Haidar C, Baker DK, Howard SC, Evans WE, Broeckel U, Relling MV. A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. Clin Pharmacol Ther 2012 Nov; 92(5):563-6 PMID:22990750

McCullers JA, Williams BF, Wu S, Smeltzer MT, Williams BF, Hayden R, Howard SC, Pui C-H, Hughes WT. Health care-associated infections at a children’s cancer hospital, 1983-2008. J Ped Infect Dis Soc, 2012; 1(1): 26-34

Inaba H, Surprise HC Pounds S, Cao X, Howard SC, Ringwald-Smith K, Buaboonnam J, Dahl G, Bowman WP, Taub JW, Campana D, Pui C-H, Ribeiro RC, Rubnitz JE. Effect of body mass index on the outcome of children with acute myeloid leukemia. Cancer 2012 118(23):5989-96. PMID:22648558

Bhakta N, Martiniuk AL, Gupta S, Howard SC. The cost-effectiveness of treating paediatric cancer in low-income and middle-income countries: a case-study approach using acute lymphocytic leukaemia in Brazil and Burkitt lymphoma in Malawi. Arch Dis Child 2013;98(2):155-60. PMID: 23201550.

Baskin JL, Lezcano E, Kim BS, Figueredo D, Lassaletta A, Perez-Martinez A, Madero L, Caniza MA, Howard SC, Samudio A, Finlay JL. Management of children with brain tumors in Paraguay. Neuro Oncol 2013; 15(2):235-41. PMID: 23197688

Quintana Y, Patel AN, Arreloa M, Antillon FG, Ribeiro RC, Howard SC. POND4Kids: A global web-based database for pediatric hematology and oncology outcome evaluation and collaboration. Stud Health Technol Inform 2013; 183:251-6. PMID: 23388293

Magrath I, Steliarova-Foucher E, Epelman S, Ribeiro RC, Harif M, Li C-K, Kebudi R, Macfarlane SD, Howard SC. Paediatric cancer in low-income and middle-income countries. Lancet Oncol 2013 Mar; 14(3):e104-116. PMID: 23434340.

Sullivan R, Kowalczyck JR, Agarwal B, Ladenstein R, Barr RD, Steliarova-Foucher E, Magrath I, Howard SC, Kruger M, Valsecchi MG, Biondi A, Grundy P, Smith MA, Adamson P, Vassal G, Pritchard-Jones K. New policies to address the global burden of childhood cancers. Lancet Oncol 2013 Mar; 14(3):e125-135. PMID: 23434339.

Marjerrison S, Antillon F, Fu L, Martinez R, Vasquez R, Bonilla M, Howard SC, Sung L. Outcome of children treated for relapsed acute lymphoblastic leukemia in Central America. Cancer 2013 Mar 15; 119(6):1277-83. PMID: 23165914

Day SW, McKeon LM, Garcia J, Wilimas JA, Carty RM, de Alarcon P, Antillon F, Howard SC. Use of joint commission international standards to evaluate and improve pediatric oncology nursing care in Guatemala. Pediatr Blood Cancer 2013 May;60(5):810-815. PMID:23015363

Israels T, Renner L, Hendricks M, Hesseling P, Howard S, Molyneux E. SIOP PODC: Recommendations for supportive care of children with cancer in a low-income setting. Pediatr Blood Cancer 2013 Jun;60(6):899-904. PMID: 23441092

Rubnitz JE, Campbell P, Zhou Y, Sandlund JT, Jeha S, Ribeiro RC, Bhojwani D, Relling MV, Howard SC, Campana D, Pui C-H. Prognostic impact of absolute lymphocyte counts at the end of remission induction in childhood acute lymphoblastic leukemia. Cancer 2013; 119(11):2061-6. PMID: 23456849

Gavidia R, Fuentes SL, Vasquez R, Bonilla M, Ethier MC, Diorio C, Caniza M, Howard SC, Sung L. Low socioeconomic status is associated with prolonged times to assessment and treatment, sepsis and infectious death in pediatric fever in El Salvador. PLoS One 2012; 7(8):e43639. PMID: 22928008

Friedman AM, Wolfson JA, Hudson MM, Weinstein HJ, Link MP, Billett A, Larsen EC, Yock T, Donaldson SS, Marcus K, Krasin MJ, Howard SC, Metzger ML. Relapse after treatment of pediatric Hodgkin lymphoma: Outcome and role of surveillance after end of therapy. Pediatr Blood Cancer 2013; 60(9):1458-63. PMID: 23677874

Hessissen L, Khtar R, Madani A, El Kababri M, Kili A, Harif M, Khattab M, Sahraoui S, Benjaafar N, Ahid S, Howard SC, Benchekroun S. Improving the prognosis of pediatric Hodgkin lymphoma in developing countries: A Moroccan Society of Pediatric Hematology and Oncology Study. Pediatr Blood Cancer 2013; 60(9):1464-9. PMID: 23606223

Pauley JL, Panetta JC, Crews KR, Pei D, Cheng C, McCormick J, Howard SC, Sandlund JT, Jeha S, Ribeiro RC, Rubnitz J, Pui C-H, Evans WE, Relling MV. Between-course targeting of methotrexate exposure using pharmacokinetically-guided dosage adjustments. Cancer Chemother Pharmacol 2013; 72(2):369-78. PMID: 23760811

Published online

Nguyen R, Coleman JL, Howard SC, Metzger ML. Watchful waiting for some children with a mediastinal mass: the potential role for 18 F-fluorodeoxyglucose positron emission tomography. Case report and review of the literature. BMC Pediatr 2013 Jul 10;13(1):103 PMID: 23841990

Bachir F, Zerrouk J, Howard SC, Graoui O, Lahjouji A, Hessissen L, Bennani S, Quessar A, El Aouad R. Outcomes in patients with mixed phenotype acute leukemia in Morocco. J Ped Hematol Oncol 2013. PMID: 23619119

Bell GC, Crews KR, Wilkinson MR, Haidar CE, Hicks JK, Baker DK, Kornegay NM, Yang W, Cross SJ, Howard SC, Freimuth RR, Evans WE, Broeckel U, Relling MV, Hoffman JM. Development and use of active clinical decision support for preemptive pharmacogenomics. J Am Med Inform Assoc 2013 Aug 26. doi: 10.1136/amiajnl-2013-001993. PMID: 23978487

Khan RB, Morris EB, Pui C-H, Hudson MM, Zhou Y, Cheng C, Ledet DS, Howard SC. Long-term outcome and risk factors for uncontrolled seizures after a first seizure in children with hematological malignancies. J Child Neurol 2013. PMID: 23666043

Wideman B, Schwartz S, Jayaprakash N, Relling MV, Christensen R, Pui C-H, Chauhan N, Daugherty C, King TR, Rush JE, Howard SC. Efficacy of glucarpidase (carboxypeptidase G2) in patients with acute kidney injury after high-dose methotrexate therapy. Pharmacotherapy 2013 Oct 17. doi: 10.1002/phar.1360. [Epub ahead of print] PMID: 24132809

Barr RD, Antillon F, Baez F, Bonilla M, Moreno B, Navarrete M, Nieves R, Peña A, Conter V, de Alarcón P, Howard SC, Ribeiro RC, Rodriguez-Galindo C, Valsecchi MG, Biondi A, Velez G, Tognoni G, Cavailli F, Masera G. Asociación de Hemato-Oncología Pediátrica de Centro América (AHOPCA): A Model for Sustainable Development in Pediatric Oncology. Pediatr Blood Cancer 2013  [Epub ahead of print] DOI 10.1002/pbc.24802