Solid Tumor: Rhabdomyosarcoma
Alternate Names: childhood rhabdomyosarcoma, embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma
What is rhabdomyosarcoma?
Rhabdomyosarcoma is a type of cancerous tumor that arises in:
- Soft tissues, such as muscles;
- Connective tissues, such as tendons; and
Rhabdomyosarcoma can occur throughout childhood and may be present at birth, which is a condition called embryonal rhabdomyosarcoma. This kind of rhabdomyosarcoma can develop anywhere in the body and is likely to spread.
Rhabdomyosarcoma in children differs from the form of the disease typically seen in adults.
How common is rhabdomyosarcoma?
- Soft tissue sarcomas account for about 7 to 8 percent of childhood cancers.
- Rhabdomyosarcoma is the most common type of soft tissue sarcoma in children.
- About two-thirds of rhabdomyosarcoma cases are diagnosed in children younger than age 6.
- More males than females and more caucasians than African-Americans develop rhabdomyosarcoma.
What are the symptoms of rhabdomyosarcoma?
Rhabdomyosarcoma symptoms are similar to those of other cancers and may include:
- A lump or swelling that does not go away
- Bleeding in the nose, vagina or rectum
- Bulging eyes
How is rhabdomyosarcoma treated?
Patients generally have surgery first.
- Surgery—is used to biopsy the tumor (remove a small portion to be examined in a laboratory) and to remove the tumor or as much of it as possible
After surgery, all patients receive chemotherapy.
- Chemotherapy (“chemo”)—uses powerful medicines to kill cancer cells or stop them from growing (dividing) and making more cancer cells:
- Chemo may be injected, so that it can travel throughout the body.
- Some chemo may be given by mouth.
- Combination therapy uses more than one type of chemo at a time.
More surgery and/or radiation therapy may be used for some patients.
- Radiation therapy—uses high-energy X-rays or other types of radiation to kill cancer cells or stop them from growing:
- External radiation uses machines outside the body to deliver the X-ray dose.
- Internal radiation uses needles, seeds, wires or catheters (tubes) to deliver the radiation directly into or close to the cancer.
What are the survival rates for rhabdomyosarcoma?
- Survival rates depend on factors such as tumor size and location and the amount of tumor that can be removed.
- More than 70 percent of children with rhabdomyosarcoma that has not spread survive long-term.
Why choose St. Jude for your child’s rhabdomyosarcoma treatment?
- St. Jude is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.
- Families never receive a bill from St. Jude for treatment, travel, housing and food – because all a family should worry about is helping their child live.
- St. Jude has created more clinical trials for cancer than any other children’s hospital in the United States.
- The nurse-to-patient ratio at St. Jude is unmatched—averaging 1:3 in hematology and oncology, and 1:1 in the Intensive Care Unit.
- The St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project study recently identifieddrugs that kill rhabdomyosarcoma tumor cells growing in the laboratory. These drugs may make chemo more effective. The research also found that two types of rhabdomyosarcoma have different genetic causes. This study provided insights into why tumors sometimes come back after treatment. Scientists are conducting further studies based on this research.
- St. Jude researchers are using a new drug combination after all therapy has finished to see if they can improve survival of children with high-risk features.
- St. Jude staff members are using new imaging techniques such as diffusion-weighted MRI to see how tumors respond to treatment.
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