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(St. Jude Reference #)
|Medulloblastoma Subtyping Assay (SJ-10-0020)|
|Description||A series of immunohistochemical tests are provided that allow medulloblastoma (and perhaps other) tumor samples to be classified into three main subgroups: those driven by the Sonic Hedgehog pathway, those driven by the Wnt pathway, and all others. This subtyping is critical for determining appropriate therapeutic treatment strategies.|
|Keywords||Medulloblastoma, Sonic Hedgehog, Subtyping|
|Granted Patents or Published Applications||International application published April 5, 2012 as WO 2012/044921|
|Related Scientific References||
Ma et al., “Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia”, Nature Genetics 28(3): 220-221 (2001)
Ellison,,D. W. et al., “Medulloblastoma: clinicopathological correlates of SHH, WNT,and non-SHH/WNT molecular subgroups”, Acta Neuropathology 121(3): 381-396 (Jan. 26, 2011).
|Licensing Opportunities||We are currently seeking licensing opportunities in all fields for the development of this technology.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: October 2012