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Finding Cures. Saving Children.
Stanislav S. Zakharenko, MD, PhD
Assistant Member, St. Jude Faculty
Departments
Developmental Neurobiology
Contact Information
Stanislav Zakharenko, MD, PhD
Developmental Neurobiology
MS 323, Room D2025B
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: stanislav.zakharenko@stjude.org
Phone: (901) 595-3837
FAX: (901) 595-3143
Education
MD
PhD
Research Interests
- Functional organization and plasticity of the auditory cortex
- Molecular and cellular mechanisms of cognitive deficits during schizophrenia
- Synaptic plasticity in the hippocampus
Selected Publications
Richardson RJ, Blundon JA, Bayazitov IT, Zakharenko SS. Connectivity patterns revealed by mapping of active inputs on dendrites of thalamorecipient neurons in the auditory cortex. Journal of Neuroscience, 2009 (in print).
Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457(7229):603-7, 2009.
Blundon JA, Zakharenko SS. Dissecting the components of long-term potentiation. The Neuroscientist 14(6):598-608, 2008.
Fraser MM, Bayazitov IT, Zakharenko SS, Baker SJ. Pten-deficiency in brain causes global hypertrophy of neuronal structure, defects in synaptic structure, synaptic transmission and plasticity, and myelination abnormalities. Neuroscience 151: 476-488, 2008.
Bayazitov IT., Richardson RJ., Fricke RG., Zakharenko SS. Slow presynaptic and fast postsynaptic components of compound long-term potentiation. Journal of Neuroscience 27(43): 11510-11521, 2007.
Ajioka I, Martins R, Bayazitov IT, Johnson D, Frase S, Donovan S, Boyd K, Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell 131(2): 378-390, 2007.
Gao J, Maison. SF, Wu X, Hirose K, Jones SM ,Bayazitov IT, Tian Y, Mittleman G, Matthews DB, Zakharenko SS, Liberman MC, Zuo J. Orphan glutamate receptor δ1 subunit is required for high-frequency hearing. Molecular and Cellular Biology 27(12):4500-4512, 2007.
Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, Oh EY, Gaber MW, Finklestein D, Allen M, Frank A, Bayazitov IT, Zakharenko SS, Gajjar A, Davidoff A, Gilbertson RJ. A perivascular niche for brain tumor stem cells. Cancer Cell 11(1):69-82, 2007.
Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H, Mukai J, Westphal KGC, Olivier B, Sulzer D, Pavlidis P, Siegelbaum SA, Karayiorgou M, Gogos JA. Transcriptional and behavioral interaction between orthologues of human 22q11.2 genes modulates schizophrenia-related phenotypes in mice. Nature Neuroscience 8(11): 1586-1594, 2005.
Shumyatsky GP, Malleret G, Shin R-M, Takizawa S, Tully K, Tsvetkov E, Zakharenko SS, Joseph J, Vronskaya S, Yin D-Q, Schubart UK, Kandel ER, Bolshakov VY. Stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Cell 123(4):697-709, 2005.
Huang YY, Zakharenko SS, Schoch S, Kaeser P, Janz R, Sudhof TC, Siegelbaum SA, Kandel ER. Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Proceedings of the National Academy of Sciences USA 102(26): 9365-9370, 2005.
Lang C, Barco A, Zablow L, Kandel ER, Siegelbaum SA, Zakharenko SS. Transient expansion of synaptically connected dendritic spines at adult hippocampal CA3-CA1 synapses upon induction of LTP. Proceedings of the National Academy of Sciences USA 101(47): 16665-16670, 2004.
Unni V, Zakharenko SS, Zablow L, Siegelbaum SA. Role of presynaptic calcium stores in NMDA-dependent LTD. Journal of Neuroscience 24 (43): 9612-9622, 2004.
Bamford NS, Zhang H, Schmitz Y, Wu NP, Cepeda C, Levine MS, Schmauss C, Zakharenko SS, Zablow L, Sulzer D. Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals. Neuron 42(4):653-663, 2004.
Zakharenko SS, Patterson SL, Dragatsis I, Zeitlin SO, Siegelbaum SA, Kandel ER, Morozov A. Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at CA3-CA1 hippocampal synapses. Neuron 39(6):975-990, 2003.
Zakharenko SS, Zablow L, Siegelbaum SA. Altered presynaptic vesicle release and cycling during mGluR dependent LTD. Neuron 35(6):1099-1110, 2002.
Zakharenko SS, Zablow L, Siegelbaum SA. Visualization of changes in presynaptic function during long-term synaptic plasticity. Nature Neuroscience 4(7):711-717, 2001.
Zakharenko S, Popov S. Membrane recycling and flow in growing neuritis. Neuroscience 97(1): 185-194, 2000.
Zakharenko S, Chang S, O’Donaghue M, Popov S. Neurotransmitter secretion along growing nerve processes: Comparison with synaptic vesicle exocytosis. Journal of Cell Biology 144(3): 507-518 1999.
Antonov I, Chang S, Zakharenko S, Popov S. Topology of exocytic events in growing axons. Neuroscience 90(3): 975-984, 1999.
Zakharenko S, Popov S. Dynamics of axonal microtubules regulates the topology of new membrane insertion into the growing neurites. Journal of Cell Biology 143(4): 1077-1086, 1998.
Last update: April 2009
