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Finding Cures. Saving Children.
Jeffrey E. Rubnitz, MD, PhD
Associate Member, St. Jude Faculty
Director, Pediatric Hematology-Oncology Fellowship Training Program
Departments
Oncology
Divisions
Leukemia / Lymphoma
Contact Information
Jeffrey Rubnitz, MD, PhD
Oncology
Leukemia / Lymphoma
MS 260, Room C-6025
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Education
MD - University of California at San Diego (1988)
PhD - University of California at San Diego (1987)
Research Interests
I am interested in developing new strategies for the treatment of acute myeloid leukemia (AML). Our new AML protocol (AML08) will determine if the combination of clofarabine and cytarabine is as effective as standard induction with cytarabine, daunomycin, and etoposide; and will test whether the infusion of haploidentical natural killer cells can reduce relapse rates. We will also explore novel therapies for certain high risk groups and continue our studies of minimal residual disease and genome-wide analysis in AML.
Selected Publications
Rubnitz JE, Crews KR, Pounds S, Yang S, Campana D, Gandhi VV, Raimondi SC, Downing JR, Razzouk BI, Pui C-H, Ribeiro RC. Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: Results of the St. Jude AML97 trial. Leukemia 2009 (in press).
Rubnitz JE, Onciu M, Pounds S, Shurtleff S, Cao X, Raimondi SC, Behm FG, Campana D, Razzouk BI, Ribeiro RC, Downing JR, Pui C-H. Acute mixed lineage leukemia in children: The experience of St. Jude Children’s Research Hospital. Blood 113:5083-5089, 2009.
Kurt B, Flynn P, Shenep JL, Ribeiro RC, Pui C-H, Lensing S, Pounds S, Razzouk BI, Rubnitz JE. Prophylactic Antibiotics Reduce Morbidity Due to Septicemia During Intensive Treatment for Pediatric Acute Myeloid Leukemia. Cancer 2008.
Rubnitz JE, Wichlan D, Devidas M, Shuster J, Linda SB, Kurtzberg J, Bell B, Hunger SP, Chauvenet A, Pui C-H, Camitta B, Pullen J. Prospective Analysis of TEL Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia: a Children’s Oncology Group Study. Journal of Clinical Oncology 2008.
Roberson JR, Onciu M, Pounds S, Rubnitz JE, Pui C-H, Razzouk BI. Prognostic significance of myeloperoxidase expression in childhood acute myeloid leukemia. Pediatric Blood and Cancer 50:542-548, 2008.
Rubnitz JE, Howard SC, Willis J, Razzouk BI, Fan Y, Pui C-H, Ribeiro RC, Pounds S, Hayden RT. Mannose binding lectin levels may not predict infection among children with leukemia. Pediatric Blood and Cancer 50:866-868, 2008.
Pieters R, Schrappe M, De Lorenzo P, Hann I, De Rossi G, Felice M, Hovi L, LeBlanc T, Szczepanski T, Ferster A, Janka G, Rubnitz J, Silverman L, Stary J, Campbell M, Li C-K, Mann G, Suppiah R, Biondi A, Vora A, Valsecchi M A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. The Lancet 370:240-250, 2007.
Lamba JK, Crews K, Pounds S, Schuetz EG, Gresham J, Gandhi V, Plunkett W, Rubnitz J, Ribeiro R. Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants. Journal of Pharmacology & Experimental Therapeutics 323:935–45, 2007.
Hijiya N, Hudson MM, Lensing S, Zacher M, Onciu M, Behm FG, Razzouk BI, Ribeiro RC, Rubnitz JE, Sandlund JT, Rivera GK, Evans WE, Relling MV, Pui C-H. Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia. JAMA 297:1207–15, 2007.
Schultz KR, Pullen JK, Sather HN, Shuster JJ, Devidas M, Borowitz MJ, Carroll AJ, Heerema NA, Rubnitz JE, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Gaynon PS, Camitta BM. Risk and response-based classification of childhood B-precursor acute lymphoblastic leukemia: A combined analysis of prognostic markers from the pediatric oncology group (POG) and children’s cancer group (CCG). Blood 109:926-935, 2007.
Rubnitz JE, Razzouk BI, Lensing S, Pounds SP, Pui C-H, Ribeiro RC. Prognostic factors and outcome of recurrence in childhood acute myeloid leukemia. Cancer 109:157-163, 2007.
Rubnitz JE, Lensing S, Razzouk BI, Pounds SP, Pui C-H, Ribeiro RC. Effect of Race on Outcome of White and Black Children with Acute Myeloid Leukemia: The St. Jude Experience. Pediatric Blood and Cancer 48:10-15, 2007.
Raimondi SC, Zhou Y, Shurtleff SA, Rubnitz JE, Pui CH, Behm FG. Near-triploidy and near-tetraploidy in childhood acute lymphoblastic leukemia: association with B-lineage blast cells carrying the ETV6–RUNX1 fusion, T-lineage immunophenotype, and favorable outcome. Cancer Genet Cytogenet 169:50-7, 2006.
Hijiya N, Panetta JC, Zhou Y, Kyzer EP, Howard SC, Jeha S, Razzouk BI, Ribeiro RC, Rubnitz JE, Hudson MM, Sandlund JT, Pui C-H, Relling MV. Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia. Blood 108:3997-4002, 2006.
Woodard P, Barfield R, Hale G, Horwitz E, Leung W, Ribeiro R, Rubnitz J, Srivastava DK, Tong X, Yusuf U, Raimondi S, Pui C-H, Handgretinger R. Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myeloid leukemia or myelodysplastic syndrome. Pediatric Blood and Cancer 47:931-935, 2006.
Jeha S, Behm F, Pei D, Sandlund JT, Ribeiro RC, Razzouk BI, Rubnitz JE, Hijiya N, Howard SC, Cheng C, Pui C-H. Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia. Blood 108:3302-3304, 2006.
Razzouk BI, Estey E, Pounds S, Lensing S, Pierce S, Brandt M, Rubnitz JE, Ribeiro RC, Rytting M, Pui C-H, Kantarjian H, Jeha S. Impact of age on outcome of pediatric acute myeloid leukemia: a report from 2 institutions. Cancer 106: 2495-2502, 2006.
Ribeiro RC, Razzouk BI, Pounds S, Hijiya N, Pui C-H, Rubnitz JE. Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000. Leukemia 19:2125-2129, 2005.
Pui C-H, Pei D, Sandlund JT, Campana D, Ribeiro RC, Razzouk BI, Rubnitz JE, Howard SC, Hijiya N, Jeha S, Cheng C, Downing JR, Evans WE, Relling MV, Hudson M. Risk of adverse events after completion of therapy for childhood acute lymphoblastic leukemia. J Clin Oncol 23:7936-7941, 2005.
Hijiya N, Liu W, Sandlund JT, Jeha S, Razzouk BI, Ribeiro RC, Rubnitz JE, Howard SC, Kyzer EP, Redd DS, Cheng C, Rivera GK, Hudson MM, Relling MV, Pui C-H. Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: lack of therapeutic role of local irradiation. Leukemia 19:1399-1403, 2005.
Rivera GK, Zhou Y, Hancock M, Gajjar A, Rubnitz J, Ribeiro RC, Sandlund JT, Hudson M, Relling M, Evans M, Pui C-H. Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia. Cancer 103:368-376, 2005.
Rocha JC, Cheng C, Liu W, Kishi S, Das S, Cook EH, Sandlund JT, Rubnitz J, Ribeiro R, Pui C-H, Evans WE, Relling MV. Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood 105:4752-4758, 2005.
Rubnitz JE, Hijiya N, Zhou Y, Hancock ML, Rivera GK, Pui C-H. Lack of benefit of early detection of relapse after completion of therapy for acute lymphoblastic leukemia. Pediatric Blood and Cancer 44:138-141, 2005.
Ross ME, Mahfouz R, Onciu M, Liu HC, Zhou X, Song G, Shurtleff SA, Pounds S, Cheng C, Ma J, Ribeiro RC, Rubnitz JE, Girtman K, Williams WK, Raimondi SC, Liang DC, Shih LY, Pui CH, Downing JR. Gene expression profiling of pediatric acute myelogenous leukemia. Blood 104:3679-3687, 2004.
Pui C-H, Sandlund JT, Pei D, Campana D, Rivera GK, Ribeiro RC, Rubnitz JE, Razzouk BI, Howard SC, Hudson MM, Cheng C, Kun LE, Raimondi SC, Behm FG, Downing JR, Relling MV, Evans WE. Improved outcome for children with acute lymphoblastic leukemia: Results of Total Therapy Study XIIIB at St. Jude Children’s Research Hospital. Blood 104:2690-2696, 2004.
Hijiya N, Metzger ML, Pounds S, Schmidt JE, Razzouk BI, Rubnitz JE, Howard SC, Nunez CA, Pui C-H, Ribeiro RC. Severe cardiopulmonary complications consistent with systemic inflammatory response syndrome caused by leukemic cell lysis in childhood acute myelomonocytic or monocytic leukemia. Pediatric Blood and Cancer 44:63-69, 2004.
Rubnitz JE, Lensing S, Zhou Y, Sandlund JT, Razzouk BI, Ribeiro RC, Pui C-H. Death during induction therapy and in first remission of acute leukemia in childhood: The St. Jude experience. Cancer 101:1677-1684, 2004.
Hijiya N, Gajjar A, Zhang Z, Sandlund JT, Ribeiro RC, Rubnitz JE, Jeha S, Liu W, Cheng C, Raimondi SC, Behm FG, Rivera GK, Relling MV, Pui C-H. Low-dose oral etoposide–based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse. Leukemia 18:1581-1586, 2004.
Hak LJ, Relling MV, Cheng C, Pei D, Wang B, Sandlund JT, Rubnitz J, Pui C-H. Asparaginase pharmacodynamics differ by formulation among children with newly diagnosed acute lymphoblastic leukemia. Leukemia 18:1072-1077, 2004.
Coustan-Smith E, Gajjar A, Hijiya N, Razzouk BI, Ribeiro RC, Rivera GK, Rubnitz JE, Sandlund JT, Andreansky M, Hancock ML, Pui C-H, Campana D. Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia after first relapse. Leukemia 18:499-504, 2004.
Rubnitz JE, Razzouk BI, Srivastava DK, Pui C-H, Ribeiro RC, Santana VM. Phase II trial of cladribine and cytarabine in relapsed or refractory myeloid malignancies. Leukemia Research 28:349-352, 2004.
Last update: June 2009
