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Parents magazine has named St. Jude Children’s Research Hospital as the No. 1 pediatric cancer care hospital in the country.
St. Jude scientists show for the first time that normal stem cells can act as the source of tumors in mature solid tissues.
New St. Jude treatment alleviates long-term anemia and organ damage in mice and paves the way for human applications.
St. Jude study shows the Prox1 gene is a two-way switch that, if turned off, causes lymphatic endothelial cells to be reprogrammed so that they lose their identity and become more like blood endothelial cells.
Scientists at St. Jude Children’s Research Hospital have identified distinctive genetic changes in the cancer cells of children with acute lymphoblastic leukemia (ALL) that cause relapse.
Scientists at St. Jude have gained new insights into regulation of one of the body’s enzyme workhorses called calpains. As the cell’s molecular overachievers, calpains function in many cellular processes, including the movement of cells in tissues, the death of damaged cells, insulin secretion, and brain cell and muscle function.
St. Jude Children's Research Hospital scientists have discovered a mechanism by which intracellular pathogens can shut down one of the body’s key chemical weapons against them: nitric oxide.
Peter Doherty, PhD, of St. Jude Children’s Research Hospital, has been elected to the Institute of Medicine (IOM), a prestigious branch of the National Academy of Sciences.
Researchers have determined how an enzyme that stitches all-important molecular adjustments onto proteins contorts itself to regulate its own function.
Study shows treatment with a newly discovered drug could be useful in sensitizing tumor cells to therapeutic irradiation and potentially some chemotherapies.
St. Jude scientists have identified one of the molecular mechanisms underlying the genetic brain malformation called holoprosencephaly (HPE). The findings not only yield insights into the most common developmental malformation of the anterior brain and face in newborns, but also help in understanding the intricate process by which the brain forms in the developing fetus.
A ubiquitous housekeeping enzyme has been found to play a major role in keeping the bone marrow environment healthy so it can nurture hematopoietic stem cells.
A ubiquitous housekeeping enzyme has been found to play a major role in keeping the bone marrow environment healthy so it can nurture hematopoietic stem cells.
The improved survival of children under 3 years old with diffuse pontine glioma compared to older children suggests that the biological properties of this cancer may be distinct in young patients.
Immune cells adjust their function like a radio dial, not an on/off light switch; a discovery that hints at how autoimmune disease may develop late in life.
St. Jude Children’s Research Hospital recently received the prestigious recognition of being designated as a National Cancer Institute (NCI) Comprehensive Cancer Center. The designation makes St. Jude the first and only cancer center solely focused on pediatric cancer to receive this distinction.
A new study shows how sounds are amplified in the inner ear, a finding that could explain how hearing loss can result from genetic mutation or overdose of drugs.
Finding that a combination of genetic mutations can cause an aggressive form of acute lymphoblastic leukemia could lead to new cancer-fighting therapies.
Physicians at St. Jude Children's Research Hospital have demonstrated that children with bilateral Wilms tumor, a cancer of the kidneys, can retain normal function in both kidneys by undergoing a procedure called bilateral nephron-sparing surgery, even when preoperative scans suggest that the tumors are inoperable.
The dramatic increase that has occurred in the cure rate for children with acute lymphoblastic leukemia (ALL) will be difficult to replicate in older patients without considerable additional research.
Researchers discover that proteins BMP2, BMP4 and BMP7 inhibit the growth of medulloblastoma tumors, while inducing malignant cells to develop into normal neurons, a finding that may lead to better treatments for the cancer.
The discovery provides insight into how certain proteins, including Hax1, work and how they control the process of apoptosis.
Children receiving treatment for cancer who are under2 years and those with very low levels of immune system cells called lymphocytes are at higher risk for severe respiratory syncytial virus related disease.
Study provides the foundation for improving understanding of N-myc gene’s role in the eyes’ growth during fetal development when retinoblastoma forms.