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Finding Cures. Saving Children.
Kitagawa R: Genome stability in germ cells
To study the physiological roles of the SAC pathway, we have analyzed the phenotype of a CeMAD1–deletion mutant strain. A significant phenotype of the CeMAD1–deletion mutant is aneuploidy in germ cells. This finding suggests that genomic stability in germ cells relies on the SAC. However, the stage of the cell cycle or developmental stage of germ cells at which SAC activity is required is unknown. We want to focus on studying the possible relation between increased susceptibility to germ cell aneuploidy and SAC activity during aging. We are currently developing a system to detect the change in frequency of chromosome missegregation during aging in C. elegans and will use it to check the role of SAC in age-related genomic instability. This study is especially important to determine why older women are at a higher risk for complications during pregnancy.
