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Finding Cures. Saving Children.
Phase I / Phase II Protocols / Clinical Studies
For information on these and other studies, contact the Developmental Therapeutics team at recurrentcancer@stjude.org.
A Study of Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic Leukemia (ALLR17)
For: acute lymphoblastic leukemia (ALL), lymphoblastic lymphoma
Phase I Study of Bevacizumab and Sorafenib Combined with Low Dose Cyclophosphamide in Patients with Refractory Solid Tumors and Leukemia
For: Recurrent or refractory solid tumors and leukemias
Reduced duration Stanford V Chemotherapy with low-dost tailored-field radiation therapy for favorable risk pediatric Hodgkin lymphoma
For: Hodgkin lymphoma
A Dose Finding Study (Phase I) of the Combination of ZD1839 (Iressa®) and Irinotecan (CamptosarTM) Given Orally in Children with Refractory Solid Tumors (AstraZeneca Protocol IRUSIRES0181)
For: Refractory solid tumors including glioblastoma, rhabdomyosarcoma, neuroblastoma, and osteosarcoma
Haploidentical hematopoietic stem cell transplantation using a novel Clofarabine containing conditioning regimen for patients with refractory hematologic malignancies
For: Acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic myeloid leukemia (CML), juvenile myelomonocytic leukemia (JMML), Hodgkin lymphoma, non-Hodgkin lymphoma, myelodysplastic syndrome (MDS)
A Phase I Study of Unmodified Live Intranasal Sendai Virus Vaccine in Children and Toddlers: Assessment of Safety and Immunogenicity (Primary Vaccination Only)
For: Croup
Phase I Study of the Combination of Vandetanib and Dasatinib Administered During and After Radiation Therapy in Children with Diffuse Intrinsic Pontine Glioma
For: Diffuse intrinsic pontine glioma
A Phase I Trial of the Humanized Anti-GD2 Antibody (HU14.18K322A) in Children and Adolescents with Neuroblastoma or Melanoma
For: Neuroblastoma or melanoma
Allogeneic Bone Marrow Transplantation for Children with Solid Malignancies
For: Solid tumors, Lymphoma
Non St. Jude Protocols
A Phase II Study of Trabectedin in Children with Recurrent Rhabdomyosarcoma, Ewing Sarcoma, or Non-Rhabdomyosarcoma Soft Tissue Sarcomas
For: Rhabdomyosarcoma, Ewing sarcoma, non-rhabdomyosarcoma soft tissue sarcomas
A Pilot Study of Lestaurtinib (CEP-701) in Combination with Chemotherapy in Young patients with Relapsed or Refractory FLT3-mutant Acute Myeloid Leukemia (AAML06P1)
For: Relapsed or refractory FLT3-mutant acute myeloid leukemia
A Phase I Study of the Safety, Tolerance, and Pharmacokinetics of Tenofovir Disoproxil Fumarate (TDF) and the Combination of TDF Plus Emtricitabine in HIV-1 Infected Pregnant Women and Their Infants
For: HIV (Human Immunodeficiency Virus) infection in pregnant women
A Phase 1 study of MK-0752 in Pediatric Patients with Recurrent or Refractory CNS Malignancies
For: Brain tumors
A Phase I Pharmacokinetic and Safety Study in Children with Recurrent or Refractory Medulloblastoma to Identify a Pharmacokinetic Based Dose for GDC-0449
For: Brain tumors
A Phase II Study of Sulindac and Tamoxifen in Patients with Desmoid Tumors that are Recurrent or Not Amenable to Standard Therapy (ARST0321)
For: Desmoid Tumor (also known as fibromatosis)
