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Finding Cures. Saving Children.
Jie Zheng, PhD
Associate Member, St. Jude Faculty
Adjunct Associate Professor, Department of Molecular Sciences, University of Tennessee Health Science Center
Departments
Structural Biology
Contact Information
Jie Zheng, PhD
Structural Biology
MS 311, Room D1024B
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: jie.zheng@stjude.org
Phone: (901) 595-3168
FAX: (901) 595-3032
Education
BS - Nankai University, Tianjin, China
PhD - City University of New York
Research Interests
Selected Publications
Lee HJ, Wang NX, Shi D-L, Zheng JJ. Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of Dishevelled. Angew Chem Int Ed 2009 (in press).
Grandy D, Shan J, Zhang X, Rao S, Akunuru S, Li H, Zheng Y, Alpatov I, Zhang XA, Lang R, Shi DL, Zheng JJ. Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol Chem 284:16256-63, 2009.
Wang NX, Zheng JJ. Computational studies of H5N1 influenza virus resistance to oseltamivir. Protein Sci 18:707-15, 2009.
Simons M, Gault WJ, Gotthardt D, Rohatgi R, Klein TJ, Shao Y, Lee HJ, Wu AL, Fang Y, Satlin LM, Dow JT, Chen J, Zheng J, Boutros M, Mlodzik M. Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat Cell Biol 11:286-94, 2009.
Lee HJ, Wang NX, Shao YM, Zheng JJ. Identification of Tripeptides Recognized by the PDZ domain of Dishevelled. Bioorg & Med Chem 17:1701-8, 2009. 10.1016/j.bmc.2008.12.060.
Bari R, Zhang YH, Zhang F, Wang NX, Stipp CS, Zheng JJ, Zhang XA. Transmembrane Interactions Are Needed for KAI1/CD82-mediated Suppression of Cancer Invasion and Metastasis. Am J Pathol 174: 647-60, 2009. PMID: 19116362.
Wu BN, Zhang YM, Rock CO, Zheng JJ. Structural modification of acyl carrier protein by butyryl group. Protein Sci 18: 240-6, 2009.
Shan J, Zheng JJ. Optimizing Dvl PDZ domain inhibitor by exploring chemical space. J Comput Aided Mol Des 23: 37-47, 2009.
Chen LJ, Wang K, Shao YM, Huang J, Li XF, Shan JF, Wu D, Zheng JJ. Structural insight into the mechanisms of Wnt signaling antagonism by Dkk. J Biol Chem 283:23364-23370, 2008. PMID: 18524778.
Wang K, Zhang YZ, Li XF, Chen LJ, Wang H, Wu JG, Zheng JJ, Wu D. Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem 283: 23371-23375, 2008. PMID: 18502762.
Zhang ZM, Simmerman JA, Guibao CD, Zheng JJ. GIT1 paxillin-binding domain is a four-helix bundle and it binds to both paxillin LD2 and LD4 motifs. J Biol Chem 283:18685-18693, 2008. PMID: 18448431.
Wang NX, Lee HJ, Zheng JJ. Therapeutic Use of PDZ Protein-Protein Interaction Antagonism. Drug News & Perspect 21:137-142, 2008.
Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W. Crystal structure of a full-length beta-catenin. Structure 16:478-487, 2008.
Bertolucci CM, Guibao CD, Zheng JJ. Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase. Biochem 47: 548-554, 2008.
Fujii N, You L, Xu Z, He B, Mikami I, Uematsu K, Shan J, Zheng J, McCormick F, Jablons DM, Guy RK. Disrupting the Protein-Protein Interaction on the PDZ Domain of Dishevelled by A Small Molecule Suppresses Tumor Progression. Cancer Research 67:573-579, 2007.
Nassar N, Cancelas J, Zheng J, Williams DA, Zheng Y. Structure-function based design of small molecule inhibitors targeting rho family GTPases. Curr Top Med Chem 6:1109-16, 2006.
Liu J, Xing Y, Hinds TR, Zheng J, Xu X. The third 20 amino acid repeat is the tightest binding site of APC for ß-catenin. J Mol Biol 360:133-144, 2006.
Dickerson JB, Morgan MA, Mishra A, Slaughter CA, Morgan JI, Zheng J. The Influence of Phosphorylation on the Activity and Structure of the Neuronal IQ Motif Protein, PEP-19. Brain Res 1092:16-27, 2006.
Obenauer JC, Denson J, Mehta JP, Su X, Mukatira S, Finkelstein DB, Xu X, Wang J, Ma J, Fan Y, Rakestraw YM, Webster RG, Hoffmann E, Krauss S, Zheng J, Zhang Z, Naeve CW. Large Scale Sequence Analysis of Avian Influenza Isolates. Science 311:1576-1580, 2006.
Akbar H, Williams DA, Zheng J, Zheng Y. Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Method in Enzymology 406:554-565, 2006.
Shan J, Shi DL, Wang, J, Zheng J. Identification of a Specific Inhibitor of the Dishevelled PDZ Domain. Biochem 44:15495-15503, 2005.
White SW, Zheng J, Zhang YM, Rock CO. The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem 74:791-831, 2005.
Bertolucci CM, Guibao CD, Zheng J. Structural Features of the Focal Adhesion Kinase–Paxillin Complex Give Insight into the Dynamics of Focal Adhesion Assembly. Protein Science 14:644-652, 2005.
London TB, Lee HJ, Shao Y, Zheng J. Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain. Biochem Biophys Res Commun 322:326-332, 2004.
Cheng Q, Wu B, Kager L, Panetta JC, Zheng J, Pui CH, Relling MV, Evans WE. A substrate specifice functional polymorphism of human g-glutamyl hydrolase alters catalytic and methotrexate polyglutamate accumulation in acute lymphoblastic leukemia cells. Pharmacogenetics 14: 554-567, 2004.
Maye P, Zheng J, Li L, Wu D. Multiple Mechanisms for Wnt11-mediated Repression of the Canonical Wnt Signaling Pathway. J Biol Chem 279: 24659 -24665, 2004.
Gao Y, Dickerson JD, Guo FK, Zheng J, Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 101: 7618-7623, 2004.
Zhang Y, Wang Y, Li,X, Zhang J, Mao J, Li Z, Insogna K, Zheng J, Li L, Harris S, Wu D. LRP5 HBM G171V Mutation Disrupts LRP5 Interaction with Mesd. Mol Cell Biol 24:4677-4684, 2004.
Yun M, Keshvara L, Park CG, Zhang YM, Dickerson JD, Zheng J, Rock CO, Curran T, and Park HK. Crystal structures of the dab homology domains of mouse disabled 1 and 2. J Biol Chem 278:36572-36581, 2003.
Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, Wu D, Mlodzik M, Shi DL and Zheng J. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 12: 1251-1260, 2003.
Zhang, Y-M, Wu B, Zheng J, and Rock CO. Key residues responsible for acyl carrier protein (ACP) and ß-ketoacyl carrier protein reductase (FabG) interaction. J Biol Chem 278: 52935-52943, 2003; 10. 1074/jbc.M309874200
Liu GH, Guibao CD, and Zheng J. 1H, 15N and 13C assignments of the targeting (FAT) domain of focal adhesion. J Biol NMR 23:75-76, 2002.
Wong HG, Liu GH, Zhang YM, Rock CO, and Zheng J. The solution structure of Acyl Carrier Protein from Mycobacterium tuberculosis. J Biol Chem 277:15874-15880, 2002.
Liu GH, Guibao CD, and Zheng J. Structural Insight into the Mechanisms of Targeting and Signaling of Focal Adhesion Kinase. Mol Cell Biol 22:2751-2760, 2002.
Wong HC, Mao J, Nguyen JT, Srinivas S, Zhang W, Liu B, Li L, Wu D, and Zheng J. Structural basis of the recognition of the dishevelled DEP domain in the wnt signaling pathway. Nat Struct Biol 7:1178-1184, 2000.
Kardinal C, Posern G, Zheng J, Knudsen BS, Moarefi I, and Feller SM. Rational development of cell-penetrating high affinity SH3 domain binding peptides that selectively disrupt the signal transduction of Crk family adapters. Amgen Peptide Technology Group. Ann N Y Acad Sci 886:289-292, 1999.
Xu H, Zheng J, Xu R, Barany G, Cowburn D. Flexibility of interdomain contacts revealed by topological isomers of bivalent consolidated ligands to the dual Src homology domain SH(32) of Abelson. Biochemistry 38: 3491-3497, 1999.
Last update: July 2009
