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Assistant Member, St. Jude Faculty
Mondira Kundu, MD, PhD
MS 343, Room D-4026C
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-6048
FAX: (901) 595-5947
MD – Jefferson Medical College, Philadelphia, Pennsylvania
PhD – Jefferson Medical College, Philadelphia, Pennsylvania
My research is motivated by a desire to develop novel insights into the pathogenesis of hematopoietic disorders, including myelodysplastic syndromes and acute leukemias, to guide the development of improved diagnostic tools and therapies. In particular, I would like to understand the molecular mechanisms involved in mitochondrial clearance and determine whether perturbations of this pathway can contribute to hematopoietic malignancies.
Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, Steeves MA, Yang CY, Prater SM, Kim DH, Thompson CB, Youle RJ, Ney PA, Cleveland JL, Kundu M. Hsp90-cdc37 chaperone complex regulates ulk1- and atg13-mediated mitophagy. Mol Cell 43(4):572-85, 2011.
Loffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M,Campbell DG, Wesselborg S, Alessi DR, Stork B. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy 7(7):696-706, 2011.
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13(2):132-71, 2011.
Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331(6016):456-61, 2011.
Kundu, M. ULK1, mTor and mitochondria: linking nutrient availability and autophagy. Antioxid Redox Signal January 14, 2011.
Bersenev A, Wu C, Balcerek J, Jing J, Kundu M, Blobel GA, Chikwava KR, Tong W. Lnk constrains myeloproliferative diseases in mice. J Clin Invest 120(6): 2058-2069, 2010.
Chen ML, Logan TD, Hochberg ML, Shelat SG, Yu X, Wilding GE, Tan W, Kujoth GC, Prolla TA, Selak MA, Kundu M, Carroll M, Thompson JE. Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. Blood 114(19):4045-53, 2009.
Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 20(7):1992-2003, 2009.
Zhang J, Kundu M, Ney PA. Mitophagy in mammalian cells: the reticulocyte model. Methods Enzymol 452:227-45, 2009.
Zhang J, Randall MS, Loyd MR, Dorsey FC, Kundu M, Cleveland JL, Ney PA. Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood 119(1): 157-164, 2009.
Kundu, M, Lindsten, T, Yang C-Y, Wu J, Zhao F, Zhang J, Selak MA, Ney PA, Thompson CB. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (First Edition Paper, prepublished online June 6, 2008).
Myung, PS, Kundu, M, Abboud, SK. Eosinophilic granuloma manifesting as painless cervical lymphadenopathy in a patient positive for human immunodeficiency virus 1. Arch Otolaryngol Head Neck Surg 134: 203-205, 2008.
Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, Ney P. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 104:19500-5, 2007.
Kundu M, Garrett L, Starost M, Eckhaus M, Speck N, Liu PP. Runx1 deficiency predisposes to T-cell lymphoblastic lymphoma in mice. Blood 106, 3621-3624, 2005.
Kundu M, Liu PP. Cbfb_is involved in maturation of all lineages of hematopoietic cells during embryogenesis except erythroid.Blood Cells, Molecules, and Diseases 30:164-169, 2003.
Kundu M, Javed A, Jeon J-P, Horner A, Shum L, Eckhaus M, Muenke M, Lian JB, Yang Y, Nuckolls G, Stein GS, Liu PP. The hematopoietic transcription factor, CBFb interacts with Runx2 and has a critical role in bone development. Nat Genetics 32:639-644, 2002.
Kundu M, Chen A, Castilla L, Anderson S, Kirby M, Bodine D, Liu PP. Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Blood 100: 2449-2456, 2002.
Lukasik SM, Zhang L, Corpora T, Tomanicek S, Li Y, Kundu M, Hartman K, Liu PP, Laue TM, Biltonen RL, Speck NA, Bushweller JH. Altered affinity of CBFbeta-SMMHC for Runx1 explains its role in leukemogenesis. Nat Struct Biol. 9: 674-670, 2002.
Darbinian N, Gallia GL, Kundu M, Shcherbik N, Tretiakova A, Gioardano A, Khalili K. Association of Pur-alpha and E2F-1 suppresses transcriptional activity of E2F-1. Oncogene 18: 6398-402, 1999.
Kundu M, Ansari SA, Chepenik LG, Pomerantz RG, Khalili K, Amini S. HIV-1 regulatory protein Tat induces RNA binding proteins in central nervous system cells that associate with the viral trans-acting-response regulatory motif. Human Virology 2: 72-80, 1999.
Kundu M*, Sharma S*, De Luca A, Giordano A, Rappaport J, Khalili K, Amini S. HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin. J Biol Chem 273: 8130-8136, 1998. *authors contributed equally
Kundu M, Guerma M, Roeder RG, Khalili K. Interaction between cell cycle regulator, E2F-1, and NF-kappa B mediates repression of the HIV-1 LTR. J Biol Chem 272: 29468-28474, 1997.
Thatikunta P, Raj G, Kundu M, Khalili K, Amini S. The transcription factor E2F-1 modulates TGF-b1 RNA expression in glial cells. Oncogene 14: 2959-2969, 1997.
Kundu M*, Sala A*, Casela I, Engelhard A, Calabretta B, Grasso L, Paggi MG, Giordano A, Watson RJ, Khalili K, Peschle C. Activation of human B-myb by cyclins. Proc Natl Acad Sci USA 94: 532-536, 1996. *authors contributed equally
Kundu M, Srinivasan A, Pomerantz RJ, Khalili K. Evidence that a cell cycle regulator, E2F-1, down-regulates transcriptional activity of the human immunodeficiency virus type 1 promoter. J Virol 69: 6940-6946, 1995.
Taylor JP, Kundu M, Khalili K. TAR-independent activation of HIV-1 requires the activation domain but not the RNA-binding domain of Tat. Virology 195: 780-785, 1993.
Chowdhury M, Kundu M, Khalili K. GA/GC-rich sequence confers Tat responsiveness to human neurotropic virus promoter, JCVL, in cells derived from central nervous system. Oncogene 8: 887-892, 1993.
Last update: March 2013