Medicine and Science News Releases

View recent medicine and science-related news releases.

St. Jude scientist named Howard Hughes Medical Institute investigator

J. Paul Taylor, M.D., Ph.D., of St. Jude Children's Research Hospital, has been recognized as one of the nation’s leading biomedical researchers by the Howard Hughes Medical Institute. (J. Paul Taylor, MD, PhD)

First cancer-promoting oncogenes discovered in rare brain tumor of children and adults

Researchers have identified three genes that play a pivotal role in the brain tumor choroid plexus carcinoma (CPC), a discovery that lays the groundwork for more effective treatment of this rare, often fatal cancer. (Richard J. Gilbertson, MD, PhD)

Childhood cancer treatment and age influence obesity risk for childhood cancer survivors

Childhood cancer survivors – especially those whose treatment included brain irradiation or chemotherapy with glucocorticoids – are 14 percent more likely to be obese than their healthy peers. (Carmen Wilson, BSc, PhD and Kirsten K. Ness, PT, PhD)

Tracking defects caused by brain tumor mutation yields insight to advance targeted therapy

St. Jude Children’s Research Hospital scientists show that mutations in the DDX3X gene lead to different molecular defects; findings will aid efforts to develop more individualized therapy of medulloblastoma. (Janet F. Partridge, PhD)

Scientists dramatically improve method for finding common genetic alterations in tumors

St. Jude Children’s Research Hospital scientists developed a new computer tool to find DNA duplications and deletions that play pivotal roles in adult and childhood cancers; the tool is free to researchers worldwide. (Jinghui Zhang, PhD)

Discovery could help reverse glucocorticoid resistance in some young leukemia patients

St. Jude Children’s Research Hospital study lays the foundation for more effective treatment of childhood leukemia and a wide range of other disorders using small molecules to reverse glucocorticoid resistance. (William E. Evans, PharmD)

Protein identified that serves as a “brake” on inflammation

Results of the St. Jude Children’s Research Hospital-led study provide a target for developing novel therapies to tame the inflammation that drives autoinflammatory diseases (Thirumala-Devi Kanneganti, PhD)

St. Jude Children’s Research Hospital opens seventh affiliate clinic

Addition extends access to clinical trials at St. Jude to children beyond its physical walls through clinical, research and academic affiliations with medical centers in six states.

St. Jude Children’s Research Hospital scientific director announces resignation

Richard Gilbertson, M.D., Ph.D., to become director of the Cambridge Cancer Centre in England (Richard Gilbertson, MD, PhD)

Experiments reveal key components of the body’s machinery for battling deadly tularemia

St. Jude Children’s Research Hospital scientists have discovered major “switches” that activate the immune system to kill the bacterium, potentially leading to protective drugs and vaccines. (Thirumala-Devi Kanneganti, PhD)

Scientists trace genomic evolution of high-risk leukemia

Whole exome sequencing of 20 pediatric ALL patients yielded important insights into the genetic basis of ALL treatment failure. The findings may lead to early detection of the mutations that drive ALL relapse. (Jinghui Zhang, PhD, and Charles G. Mullighan, MBBS(Hons), MSc, MD)

Measuring treatment response proves to be a powerful tool for guiding leukemia treatment

Measuring the concentration of leukemia cells in patient bone marrow during the first 46 days of chemotherapy helps boost survival of young leukemia patients by better matching patients with the right intensity of chemotherapy. (Ching-Hon Pui, MD)

St. Jude Children’s Research Hospital appoints new chair of Department of Radiation Oncology

Thomas Merchant, D.O., Ph.D., to oversee radiotherapy programs for the treatment of childhood cancer. (Thomas Merchant, DO, PhD)

Chromosomal rearrangement is the key to progress against aggressive infant leukemia

St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project study highlights need for targeted therapies against a rare infant leukemia with a poor prognosis. (James R. Downing, MD)

Researchers map "genomic landscape" of childhood adrenocortical tumors for the first time

St. Jude Children’s Research Hospital scientists identify key molecular events in pediatric adrenocortical tumors; findings could help clinicians identify most malignant subtypes and lead to better treatment. (Raul Ribeiro, MD; Jinghui Zhang, PhD; and Gerard Zambetti, PhD)

St. Jude Children’s Research Hospital makes FORTUNE's “100 Best Companies to Work For” list for fifth straight year

St. Jude Children’s Research Hospital has been recognized for the fifth year in a row as one of FORTUNE magazine’s “100 Best Companies to Work For.”

Sun damage causes genetic changes that predispose children and adolescents to melanoma

St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project has identified the genetic basis of three pediatric melanoma subtypes; findings could lead to better diagnosis and treatment. (Alberto Pappo, MD and Armita Bahrami, MD)

Inherited gene variation leaves young leukemia patients at risk for peripheral neuropathy

Research led by St. Jude Children’s Research Hospital investigators could help reduce side effects associated with the anti-cancer drug vincristine, which is widely used to treat cancer in children and adults. (William E. Evans, PharmD)

Possible strategy identified to combat major parasitic tropical disease

St. Jude Children’s Research Hospital scientists report results that suggest neutralizing a single protein may aid fight against a parasitic tropical disease that annually sickens more than 1.3 million people worldwide. (Thirumala-Devi Kanneganti, PhD)

Survivors of childhood cancer at risk for developing hormone deficiencies as adults

St. Jude Children’s Research Hospital finds childhood cancer patients treated with cranial irradiation may have hormone deficiencies that impact health decades later; results highlight need for lifelong health screenings. (Wassim Chemaitilly, MD)

Inherited gene variations tied to treatment-related hearing loss in cancer patients

St. Jude Children’s Research Hospital scientists have identified inherited genetic variations associated with hearing loss in young cancer patients treated with cisplatin, a drug widely used to treat adults with cancer. (Jun J. Yang, PhD, Clinton Stewart, PhD, and Giles Robinson, MD)

St. Jude Children’s Research Hospital scientist honored for contributions to immunology

Thirumala-Devi Kanneganti, Ph.D., of St. Jude Children’s Research Hospital, is recognized by the American Association of Immunologists for outstanding research contributions to the field of immunology. (Thirumala-Devi Kanneganti, PhD)

Inherited gene variation helps explain drug toxicity in patients of East Asian ancestry

St. Jude researchers have identified an inherited variation in the NUDT15 gene that is strongly associated with a low tolerance for a drug that is a mainstay of pediatric ALL treatment. The finding is expected to impact ALL treatment. (Jun J. Yang, PhD)

Tumor suppressor protein plays key role in maintaining immune balance

St. Jude Children’s Research Hospital scientists show that the PTEN tumor suppressor protein is essential for proper regulatory T cell function; discovery offers new focus for improving treatment of autoimmune diseases. (Hongbo Chi, PhD)