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Finding Cures. Saving Children.
Suzanne J. Baker, PhD
Member, St. Jude Faculty
Departments
Developmental Neurobiology
Contact Information
Suzanne Baker, PhD
Developmental Neurobiology
Room D2006C
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: suzanne.baker@stjude.org
Phone: (901) 595-2254
FAX: (901) 595-2270
Education
PhD - The Johns Hopkins University, Baltimore, MD
Research Interests
The laboratory is focused on understanding growth regulation and tumor suppression in the brain. Our approach uses in vivo and in vitro model systems to analyze the function of genes of known importance in human glioma, in the context of normal brain development and gliomagenesis. We have developed in vivo models that demonstrated the complexity of signal transduction through the PI3K-PTEN pathway. We also are studying the mutations underlying the formation of pediatric high grade gliomas using array based analyses of primary human tumor samples.
Selected Publications
Chalhoub N, Zuo G, Zuo , Baker SJ. Cell-type specificity of PI3K signaling in Pdk1- and Pten-deficient brain. Genes Dev 2009 (in press).
Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LM, Baker SJ, Sorrentino BP, Dyer MA. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci USA 106:6685-6690, 2009.
Frappart P-O, Lee Y, Russell HR, Chalhoub N, Wang Y-D, Orii KE, Zhao J, Kondo N, Baker SJ, McKinnon PJ. Genetic Alterations in medulloblastoma from mice with defective DNA double strand break repair. Proc Natl Acad Sci USA 106:1880-1885, 2009.
Chalhoub N, Baker SJ. PTEN and the PI3K Signaling Pathway in Cancer. Annu Rev Pathol 4:127-150, 2009.
Broniscer A, Baker SJ, Stewart CF, Merchant TE, Laningham FH, Schaiquevich P, Kocak M, Morris EB, Endersby R, Ellison DW, Gajjar A. Phase I and Pharmacokinetic Studies of Erlotinib Administered Concurrently With and After Radiotherapy for Children, Adolescents, and Young Adults with High-Grade Glioma. Clin Cancer Res 15:701-707, 2009.
Endersby R, Baker SJ. PTEN Signaling in Brain: Neuropathology and Tumorigenesis. Oncogene 27:5416-5430, 2008.
Chow LML, Zhang J, Baker SJ. Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Research 17:919-928, 2008.
Weber T, Corbett MK, Chow LM, Valentine MB, Baker SJ, Zuo J. Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells. Proc Natl Acad Sci USA105: 781-785, 2008.
Fraser MM, Bayazitov IT, Zakharenko SS, Baker SJ. Pten deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience 151:476-488, 2008.
Torchia EC, Boyd K, Rehg JE, Qu C, Baker SJ. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol 27: 7918-7934, 2007.
Broniscer A, Baker SJ, West AN, Fraser MM, Proko E, Kocak M, Dalton J, Zambetti GP, Ellison DW, Kun LE, Gajjar A, Gilbertson RJ, Fuller CE. Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. J Clin Oncol 25: 682-689, 2007.
Baker SJ. PTEN Enters the Nuclear Age. Cell 128: 125-8, 2007.
Kawaguchi T, Yamashita Y, Kanamori M, Bankiewicz KS, Endersby R, Baker SJ, Bergers G, Pieper RO. The PTEN/AKT pathway dictates the direct aVb3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Canc Res 66: 11331-40, 2006.
Hayes MP, Wang H, Espinal-Witter R, Douglas W, Solomon G, Baker SJ, Ellenson LH. PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia. Clin Cancer Res12: 5932-5, 2006.
Chow LM, Tian Y, Weber T, Corbett M, Zuo J, Baker SJ. Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Dev Dyn 11: 2991-8, 2006.
Chalhoub N, Kozma SC, Baker SJ. S6k1 is not required for Pten-deficient neuronal hypertrophy. Brain Res 1100:32-41, 2006.
Kwon C-H, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF. Pten regulates neuronal arborization and social interaction in mice. Neuron 50: 377-388, 2006.
Chow LM, Baker SJ. PTEN function in normal and neoplastic growth. Cancer Lett 241: 184-196, 2006.
Kwon CH, Zhou J, Li Y, Kim KW, Hensley LL, Baker SJ*, Parada LF. Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations. Genesis 44:130-135, 2006 (*co-corresponding authors).
Edwin F, Singh R, Endersby R, Baker SJ, Patel TB. PTEN is necessary for human Sprouty2-mediated inhibition of cell proliferation. J Biol Chem 281:4816-4822, 2006.
Abel TW, Baker SJ, Fraser MM, Tihan T, Nelson JS, Yachnis A, Bouffard J, Mena H, Burger PC, Eberhart CG. Lhermitte-Duclos Disease: a Report of 31 Cases with Immunohistochemical Analysis of the PTEN/AKT/mTOR Pathway. J Neuropathol Exp Neurol 64:341-349, 2005.
Fraser MM, Zhu X, Kwon C-H, Uhlman EJ, Bajenaru ML, Gutmann DH, Baker SJ. Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res 64:7773-7779, 2004.
Yang CH, Murti A, Baker SJ, Frangou-Lazaridis M, Vartapetian AB, Murti KG, Pfeffer LM. Interferon induces the interaction of prothymosin-α with STAT3 and results in the nuclear translocation of the complex. Exp Cell Res 298:197-206, 2004.
Baker SJ and McKinnon PJ. Tumour-suppressor function in the nervous system. Nat Rev Cancer 4, 184-96, 2004.
Torchia EC, Jaishankar S and Baker SJ. Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells. Cancer Res 63, 3464-8, 2003.
Kwon CH, Zhu X, Zhang J and Baker SJ. mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci USA 100, 12923-8, 2003.
Gutmann DH, Baker SJ, Giovannini M, Garbow J and Weiss W. Mouse models of human cancer consortium symposium on nervous system tumors. Cancer Res 63, 3001-4, 2003.
Baker SJ, Kinzler KW and Vogelstein B. Knudson's hypothesis and the TP53 revolution. Genes Chromosomes Cancer 38, 329, 2003.
Baker SJ. Redefining p53--entering the tumor suppressor era. Cell Cycle 2, 7-8, 2003.
Zhu X, Kwon CH, Schlosshauer PW, Ellenson LH and Baker SJ. PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells. Cancer Res 61, 4569-75, 2001.
Kwon CH, et al. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet 29, 404-11, 2001.
Knoop LL and Baker SJ. EWS/FLI alters 5'-splice site selection. J Biol Chem 276, 22317-22, 2001.
Last update: June 2009
