A Pilot Study On The Effects Of Preoperative Physical Therapy In Adolescents And Young Adults Diagnosed With A Lower Extremity Malignancy

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Research

Solid Tumors

Supportive Solid Tumor Studies

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Non-Therapeutic Protocol

PTSARC: A Pilot Study On The Effects Of Preoperative Physical Therapy In Adolescents And Young Adults Diagnosed With A Lower Extremity Malignancy

Type of Protocol/Clinical Study

Associated Solid Tumor Studies : Solid tumors

Description

This study evaluates the feasibility and the effect of adding a focused physical therapy intervention to the preoperative regimen in individuals diagnosed with a malignancy of the lower extremity. The intervention group will receive preoperative physical therapy at least 3 times per week for 60 minutes each session to the uninvolved leg. The therapy sessions will include endurance, strengthening, and stretching exercises. The results measures for this study are the Functional Mobility Assessment (FMA), strength and range of motion (ROM) of bilateral lower extremities (BLE’s). PT to be conducted for 10 weeks prior to the limb sparing procedure or amputation and for 10-12 weeks after the limb sparing procedure or amputation.

Objectives

Primary

To determine if individuals diagnosed with a malignancy of the LE can participate in a 10 week preoperative strengthening, stretching, and aerobic exercise regimen.

Exploratory

To evaluate the impact of preoperative strengthening and aerobic exercise training on function at 10-12 weeks postoperatively in children diagnosed with a malignancy of the LE who will be receiving a limb sparing procedure or amputation.

Eligibility

Inclusion Criteria

Participant must be between the ages of 6 and 30 years of age.
Participant must be granted permission by physician.
Participant has negative pregnancy test.
Lansky score > 50 for participants age < 16 years of age.
Karnofsky score of > 50 or WHO/ECOG < 2 if > 16 years of age.
Participant has a newly diagnosed lower extremity malignancy as shown by biopsy; previously untreated and surgical intervention is primary local control and is being treated at St. Jude Children’s Research Hospital.

Exclusion Criteria

Participants with serious, non-healing wound, ulcer or bone fracture.
Participant has a pre-morbid condition that prevents participant from ambulating.
Patients who do not have at least 10 weeks before receiving local control.

Principal Investigator

Angela Meyer Corr, PT, DPT

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

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