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St. Jude Children’s Research Hospital solves mystery of enzyme’s role in cell survival, offering clues of how immune system fights infection and possible strategies to treat problems ranging from heart attack to cancer. (Douglas Green, PhD)
Cells may be small, but they are home to plenty of mystery and drama. Take the enzyme known as RIPK1. St. Jude Children’s Research Hospital scientists have just determined that after birth, RIPK1 functions like an umpire in cells, making the tough calls necessary to balance competing signals that determine if cells live or die.
St. Jude Children’s Research Hospital analysis reveals how the protein p53, which triggers cancer cells to commit suicide, attaches to its regulatory molecule; findings could lead to drugs to unleash p53 to battle a range of cancers. (Richard Kriwacki, PhD, and Douglas Green, PhD)
Work led by St. Jude Children’s Research Hospital investigators provides fresh insight into mechanisms controlling programmed cell death pathways and offers new targets in the fight against cancer and virus-infected cells.
Scientists at St. Jude have gained new insights into regulation of one of the body’s enzyme workhorses called calpains.
St. Jude investigators have discovered that immune system cells that engulf and destroy germs in the body enlist help for this task from a common housekeeping mechanism most cells use to keep their interiors healthy.
The discovery of how some abnormal cells can avoid a biochemical program of self-destruction by increasing their energy level and repairing the damage is giving St. Jude investigators insights into a key strategy cancer cells use to survive and thrive.
It's a plot that turns on a cell's precarious dance of life and death. St. Jude scientists are determined to write the book on cell suicide.
St. Jude researchers discover process is not step-by-step as previously thought; discovery unlocks more information on how cells "commit suicide."
How mitochondria are recruited during times of stress to choreograph apoptosis - the cell's dance of death - is a story that fails to tell which particular set of steps the cells use most often, according to investigators at St. Jude and La Jolla.
The appointment of three nationally renowned investigators to major faculty positions will significantly bolster research aimed at increasing survival rates of children with cancer while reducing treatment toxicity.