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    Green: News Releases & Feature Stories

    Molecule acts as umpire to make tough life-or-death calls

    St. Jude Children’s Research Hospital solves mystery of enzyme’s role in cell survival, offering clues of how immune system fights infection and possible strategies to treat problems ranging from heart attack to cancer. (Douglas Green, PhD)

    Molecule acts as umpire to make tough life-or-death calls

    Cells may be small, but they are home to plenty of mystery and drama. Take the enzyme known as RIPK1. St. Jude Children’s Research Hospital scientists have just determined that after birth, RIPK1 functions like an umpire in cells, making the tough calls necessary to balance competing signals that determine if cells live or die.

    Detailed studies reveal how key cancer-fighting protein is held in check

    St. Jude Children’s Research Hospital analysis reveals how the protein p53, which triggers cancer cells to commit suicide, attaches to its regulatory molecule; findings could lead to drugs to unleash p53 to battle a range of cancers. (Richard Kriwacki, PhD, and Douglas Green, PhD)

    Protein identified that serves as a switch in a key pathway of programmed cell death

    Work led by St. Jude Children’s Research Hospital investigators provides fresh insight into mechanisms controlling programmed cell death pathways and offers new targets in the fight against cancer and virus-infected cells.

    New insight into the controls on a go-to enzyme

    Scientists at St. Jude have gained new insights into regulation of one of the body’s enzyme workhorses called calpains.

    Link between cellular defense processes shows how cancer cells survive

    St. Jude investigators have discovered that immune system cells that engulf and destroy germs in the body enlist help for this task from a common housekeeping mechanism most cells use to keep their interiors healthy.

    Cells re-energize to come back from the brink of death

    The discovery of how some abnormal cells can avoid a biochemical program of self-destruction by increasing their energy level and repairing the damage is giving St. Jude investigators insights into a key strategy cancer cells use to survive and thrive.

    Cell Suicide: A "Howdunit" Mystery

    It's a plot that turns on a cell's precarious dance of life and death. St. Jude scientists are determined to write the book on cell suicide.

    Key event in cell death occurs as single, quick event

    St. Jude researchers discover process is not step-by-step as previously thought; discovery unlocks more information on how cells "commit suicide."

    The "upstairs/downstairs" mystery of cell suicide is burdened by too much evidence

    How mitochondria are recruited during times of stress to choreograph apoptosis - the cell's dance of death - is a story that fails to tell which particular set of steps the cells use most often, according to investigators at St. Jude and La Jolla.

    New chairs will help boost cancer research in key areas

    The appointment of three nationally renowned investigators to major faculty positions will significantly bolster research aimed at increasing survival rates of children with cancer while reducing treatment toxicity.