RIG-I Transgenic Chicken (SJ-10-0010)

Technology Name
(St. Jude Reference #)
RIG-I Transgenic Chicken (SJ-10-0010)
Description When researchers at St. Jude and the University of Alberta discovered retinoic acid-inducible gene I (RIG-I) is absent in chickens, they conceived that generation of a transgenic chicken to express (RIG-I) may increase the chicken's resistance to influenza. They expressed duck RIG-I in chicken fibroblasts and saw a 50-70% decrease in influenza virus replication, including the highly pathogenic H5N1. In addition to influenza resistance, other benefits associated with such a transgenic chicken include an increase in the efficacy of vaccination and a decrease in influenza transmission, both within chickens and across species.
Keywords Poultry, influenza resistance, retinoic acid-inducible gene I
Granted Patents or Published Applications Provisional patent application filed
Related Scientific References Barber MR, Aldridge JR Jr, Webster RG, Magor KE; Association of RIG-I with innate immunity of ducks in influenza; Proc Natl Acad Sci USA 2010 Mar 30; 107(13):5913-8.
Licensing Opportunities TEC Edmonton, the University of Alberta's commercialization entity, is taking the lead in licensing this technology. We are seeking licensing opportunities in all fields.


Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.


Last update: September 2010