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|Technology Name |
(St. Jude Reference #)
|RIG-I Transgenic Chicken (SJ-10-0010)|
|Description||When researchers at St. Jude and the University of Alberta discovered retinoic acid-inducible gene I (RIG-I) is absent in chickens, they conceived that generation of a transgenic chicken to express (RIG-I) may increase the chicken's resistance to influenza. They expressed duck RIG-I in chicken fibroblasts and saw a 50-70% decrease in influenza virus replication, including the highly pathogenic H5N1. In addition to influenza resistance, other benefits associated with such a transgenic chicken include an increase in the efficacy of vaccination and a decrease in influenza transmission, both within chickens and across species.|
|Keywords||Poultry, influenza resistance, retinoic acid-inducible gene I|
|Granted Patents or Published Applications||Provisional patent application filed|
|Related Scientific References||Barber MR, Aldridge JR Jr, Webster RG, Magor KE; Association of RIG-I with innate immunity of ducks in influenza; Proc Natl Acad Sci USA 2010 Mar 30; 107(13):5913-8.|
|Licensing Opportunities||TEC Edmonton, the University of Alberta's commercialization entity, is taking the lead in licensing this technology. We are seeking licensing opportunities in all fields.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2010