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(St. Jude Reference #)
|New Uses for Chloroquine and Chloroquine Analog
(SJ-02-0008 and SJ-05-0017)
|Description||The following new uses for chloroquine and chloroquine analogs are provided:
|Keywords||chloroquine, metabolic syndrome, hypoxia-reperfusion injury, radiation|
|Granted Patents or Published Applications||U.S. Patent Nos. 6,916,627; 7,108,992; 7,160,692 and 7,279,290. Pending U.S. Patent Appln. Pub. Nos. 2008/0319010 and 2009/0099134.|
|Related Scientific References||
Bakkenist, C. et al. ” DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation”, Nature 421: 499-506 (2003); see also related commentary by Bartek, J. and Lukas, J., Nature 421: 486-488 (2003);
Kastan, M.B. and Bartek, J., “Cell-cycle checkpoints and cancer”, Nature 432: 316-323 (2004);
Schneider, J.G. et al., “ATM-dependent suppression of stress signaling reduces vascular disease inmetabolic syndrome”, Cell Metab.4: 377-389 (Nov. 2006); see also related commentary by Shoelson, S., Cell Metab.4: 337-338 (Nov. 2006).
|Licensing Opportunities||We are currently seeking nonexclusive licensing opportunities in the described fields for the development and use of this technology.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2010