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Research
| Technology Name (St. Jude Reference #) |
New Uses for Chloroquine and Chloroquine Analog (SJ-02-0008 and SJ-05-0017) |
| Description | The following new uses for chloroquine and chloroquine analogs are provided:
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| Keywords | chloroquine, metabolic syndrome, hypoxia-reperfusion injury, radiation |
| Granted Patents or Published Applications | U.S. Patent Nos. 6,916,627; 7,108,992; 7,160,692 and 7,279,290. Pending U.S. Patent Appln. Pub. Nos. 2008/0319010 and 2009/0099134. |
| Related Scientific References |
Bakkenist, C. et al. ” DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation”, Nature 421: 499-506 (2003); see also related commentary by Bartek, J. and Lukas, J., Nature 421: 486-488 (2003); Kastan, M.B. and Bartek, J., “Cell-cycle checkpoints and cancer”, Nature 432: 316-323 (2004); Schneider, J.G. et al., “ATM-dependent suppression of stress signaling reduces vascular disease inmetabolic syndrome”, Cell Metab.4: 377-389 (Nov. 2006); see also related commentary by Shoelson, S., Cell Metab.4: 337-338 (Nov. 2006). |
| Licensing Opportunities | We are currently seeking nonexclusive licensing opportunities in the described fields for the development and use of this technology. |
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2010
