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Patients undergoing autologous hematopoietic stem cell transplantation must have either peripheral blood or bone marrow stem cells collected and cryopreserved before transplantation. As part of the pre-evaluation before stem cell collection, patients must undergo infectious disease testing, which is standard for all persons donating blood products. In addition, the primary physician or a transplant physician must examine the patient to determine whether he or she is medically able to proceed with stem cell collection.
Peripheral blood stem cells are usually collected after treatment with chemotherapy and the growth factor granulocyte colony-stimulating factor (G-CSF). In some circumstances, patients who do not require additional chemotherapy may have stem cells collected after growth factor administration alone.
Alternatively a bone marrow harvest may be done at any time after the white blood cell counts have reached normal values. Before stem cells are collected, the patients will meet with a stem cell transplant physician to review the procedure for stem cell collection.