Melissa M. Hudson, MD

Member, St. Jude Faculty
Director, Cancer Survivorship Division
Co-Leader, Cancer Prevention & Control Program

Departments

Oncology
Epidemiology and Cancer Control
Psychology

Divisions

Cancer Survivorship
Leukemia / Lymphoma

Contact Information

Melissa Hudson, MD
Cancer Survivorship
MS 735, Room S-6046
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: melissa.hudson@stjude.org
Phone: (901) 595-3384
FAX: (901) 595-5845

Education

BS - Texas A & M University, College Station, Texas (1979)
MD - University of Texas Medical School at Houston (1983)

Research Interests

• Protocol development and clinical investigations in Hodgkin lymphoma
• Late effects of cancer therapy
• Health education and promotion in childhood cancer survivors

Current Research

• Evaluation of Cardiovascular Outcomes among Survivors (ECHOS), Co-Principal Investigator
• Childhood Cancer Survivor Study (CCSS) Principal Investigator
• Feasibility Study for Project Protocol for Collecting Data on Childhood Cancer Survivors (STJLTFU) Principal Investigator
• Passport for Care: Implementation in Multiple Institutions (SJPFC) Principal Investigator
• Key Adverse Events Following Childhood Cancer (ALTE03N1) Principal Investigator
• Establishment of a Lifetime Cohort of Adults Surviving Childhood Cancer (SJLIFE) Principal Investigator
• Low Dose Tamoxifen in Hodgkin’s Disease Survivors for Breast Cancer Risk Reduction (LDTAM) Co-Investigator
• Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors (PREVENT) Co-Investigator

    Hodgkin and Solid Tumors

• Risk-Adapted Therapy for Pediatric Hodgkin’s Disease (HOD99) Co-Investigator
• Stanford V Chemotherapy with Low-Dose Tailored-Field Radiation Therapy for Intermediate Risk Pediatric Hodgkin’s Disease (HOD05) Co-Investigator
• Reduced Duration Stanford V Chemotherapy with Low-dose Tailored-field Radiation Therapy for Favorable Risk Pediatric Hodgkin Lymphoma (HOD08) Co-Investigator
• Health-Related Outcomes for Hodgkin Disease Survivors (ALTE04N1) Principal Investigator

    Psychosocial and Educational

• Measurement of Adaptive Style in Children with Cancer: Use of Psychophysiological Assessment in a Laboratory Stress Paradigm (ADSTY1) Co-Investigator [Accrual Closed; Open for Follow up]
• Measurement of Adaptive Style in Children with Cancer: II Relationship to Tolerance of Anti-Cancer Therapy (ADSTY2) Co-Investigator [Accrual Closed; Open for Follow up]
• Adaptive Style and Attention Bias in Children with Cancer: A Pilot Study (ADSTY3) Co-Investigator [Accrual Closed; Open for Follow up]
• Pilot Study of Primary and Secondary Attention-Deficit/Hyperactivity Disorder among Survivors of Childhood Cancer (SADHD1) Co-Investigator
• Relationship of Adaptive Style and Optimism in Children with Cancer: Examining Their Validity as Predictors of Psychosocial Outcomes (CSD5) Co-Investigator [Accrual Closed; Open for Follow up]
• Long-Term Treatment Related CNS Injury in Survivors of Childhood Acute Lymphoblastic Leukemia (CNSRI) Co-Investigator [Accrual Closed; Open for Follow up]
• Cognitive Remediation in Childhood Cancer Patients (COGRM1) Co-Investigator
• Human Papillomavirus Vaccination among Survivors of Childhood Cancer (HPV1) Co-Investigator
• Quadrivalent Human Papillomavirus (qHPV) Vaccine in Cancer Survivors: Cross Sectional Survey and Phase II Open-Label Vaccine Trial (CSqHPV) Co-Investigator
• Sperm Banking among Adolescents Newly Diagnosed with Cancer: Development of a Profiling and Referral Tool (SBANK10) Co-Investigator
• Risk of Psychopathology and Neurocognitive Impairment in Leukemia Survivors (NEULS) Co-Investigator
• Assessment of Sleep complaints in Brain Tumor Survivors (PBTSLP) Co-Investigator
• Perceived Cognitive Function Item Bank for Children Who Undergo Cancer Treatment (PEDPCF) Co-Investigator
• Clinical Implementation of Pharmacogenetics (PG4KDS) Co-Investigator
• Stress, Adjustment and Growth in Children with Cancer and Their Parents (PTSD2) Co-Investigator

    Physical Performance and Activity

• Comparison Group Recruitment Feasibility Study for Physical Performance and Physical Activity (MOPALS) Co-Investigator [Accrual Closed; Open for Follow up]
• Motor Proficiency and Physical Activity in Adult Survivors of Childhood ALL (MTRPAL) Co-Investigator
• Vibration Intervention for Bone Enhancement in Childhood Cancer Survivors (VIBE) Co-Investigator[Accrual Closed; Open for Follow up]

    Tobacco and Smoking Cessation

• Efficacy of a Tobacco Quit Line for Childhood Cancer Survivors (XPD07-140; QUITLINE) Co-Investigator
• Comparison of Risk Factors Associated With Tobacco Use Between Pre-Adolescent and Adolescent Cancer Patients and Healthy Pre-Adolescents and Adolescents (SMOKN2) Co-Investigator [Accrual Closed; Open for Follow up]
• Reduction of Environmental Tobacco Smoke (ETS) Exposure in Pediatric Cancer Patients ( SMOKN5) Co-Investigator
• A web-based smoking intervention for cancer survivors (SMOKN6) Co-Investigator [Accrual Closed; Open for Follow up]

Selected Publications

Armstrong GT, Plana JC, Zhang N, Zhang N, Srivastava D, Green DM, Ness KK, Donovan FD, Metzger ML, Arevalo A, Durand JB, Joshi V, Hudson MM, Robison LL, Flamm SD. Screening adult survivors of childhood cancer for cardiomyopathy: comparison of echocardiography and cardiac magnetic resonance imaging. J Clin Oncol 30:2876-84, 2012.

Krull KR, Sabin ND, Reddick WE, Zhu L, Armstrong GT, Green DM, Arevalo AR, Krasin MJ, Srivastava DK, Robison LL, Hudson MM. Neurocognitive function and CNS integrity in adult survivors of childhood Hodgkin lymphoma. J Clin Oncol 30:3618-3624, 2012.

Nottage K, McFarlane J, Krasin MJ, Li C, Srivastava D, Robison LL, Hudson MM. Secondary colorectal carcinoma after childhood cancer. J Clin Oncol June 4, 2012.

Metzger ML, Weinstein HJ, Hudson MM, Billett AL, Larsen EC, Friedmann A, Howard SC, Donaldson SS, Krasin MJ, Kun LE, Marcus KJ, Yock TI, Tarbell N, Billups CA, Wu J, Link MP. Association between radiotherapy vs no radiotherapy based on early response to VAMP chemotherapy and survival among children with favorable-risk Hodgkin lymphoma. JAMA 307:2609-16, 2012.

Hudson MM, Neglia JP, Woods WG, Sandlund JT, Pui CH, Kun LE, Robison LL, Green DM. Lessons from the past: Opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies. Pediatr Blood Cancer 58(3):334-343, 2011.

Castellino SM, Geiger AM, Mertens AC, Leisenring WM, Tooze JA, Goodman P, Stovall M, Robison LL, Hudson MM. Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study. Blood 117(6):1806-1816, 2011.

Hudson MM, Ness KK, Nolan VG, Armstrong GT, Green DM, Morris EB, Spunt SL, Metzger ML, Krull KR, Klosky JL, Srivastava DK, Robison LL. Prospective medical assessment of adults surviving childhood cancer: study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort Study. Pediatr Blood Cancer 56(5):825-836, 2010.

Nathan PC, Hayes-Lattin B, Sisler JJ, Hudson MM. Critical issues in transition and survivorship for adolescents and young adults with cancers. Cancer 117(10 Suppl):2335-2341, 2011.

Oeffinger KC, Hudson MM, Mertens AC, Smith SM, Mitby PA, Eshelman-Kent DA, Ford JS, Jones JK, Kamani S, Robison LL. Increasing rates of breast cancer and cardiac surveillance among high risk survivors of childhood Hodgkin lymphoma following a mailed, one-page survivorship care plan. Pediatr Blood Cancer 56(5):818-824, 2011.

Casillas J, Castellino SM, Hudson MM, Mertens AC, Lima ISF, Liu Q, Zeltzer LK, Yasui Y, Robison LL, Oeffinger KC. Impact of insurance type on survivor-focused and general preventive health care utilization in adult survivors of childhood cancer: the Childhood Cancer Survivor Study (CCSS). Cancer 117(9):1966-1975, 2011.

Hudson MM. Reproductive outcomes for survivors of childhood cancer. Obstet Gynecol 116(5):1171-1183, 2010.

Klosky JL, Tyc VL, Hum A, Lensing S, Buscemi J, Garces-Webb DM, Hudson MM. Establishing the predictive validity of intentions to smoke among preadolescents and adolescents surviving cancer. J Clin Oncol 28(3):431-6, 2010

Nathan PC, Ness KK, Mahoney MC, Li Z, Hudson MM, Ford JS, Landier W, Stovall M, Armstrong GT, Henderson TO, Robison LL, Oeffinger KC. Screening and surveillance for second malignant neoplasms in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Ann Intern Med 153(7):442-451, 2010.

Henderson TO, Amsterdam A, Bhatia S, Hudson MM, Meadows AT, Neglia JP, Diller LR, Constine LS, Smith RA, Mahoney MC, Morris EA, Montgomery LL, Landier W, Smith SM, Robison LL, Oeffinger KC. Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer: a report from the Children’s Oncology Group. Ann Intern Med 152(7):444-55, 2010.

Hudson MM, Mulrooney DA, Bowers DC, Sklar CA, Green DM, Donaldson SS, Oeffinger KC, Neglia JP, Meadows AT, Robison LL. High-risk populations identified in Childhood Cancer Survivor Study investigations: implications for risk-based surveillance. J Clin Oncol 27:2405–14, 2009.

Ness KK, Leisenring WM, Huang S, Hudson MM, Gurney JG, Whelan K, Hobbie WL, Armstrong GT, Robison LL, Oeffinger KC. Predictors of inactive lifestyle among adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Cancer 115:1984–94, 2009.

Cox CL, Montgomery M, Oeffinger KC, Leisenring W, Zeltzer L, Whitton JA, Mertens AC, Hudson MM, Robison LL. Promoting physical activity in childhood cancer survivors: results from the Childhood Cancer Survivor Study. Cancer 115:642–54, 2009.

Oeffinger KC, Ford JS, Moskowitz CS, Diller LR, Hudson MM, Chou JF, Smith SM, Mertens AC, Henderson TO, Friedman DL, Leisenring WM, Robison LL. Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer. JAMA 301:404–14, 2009.

Other publications

Last update: February 2013