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(St. Jude Reference #)
|Anaplastic Lymphoma Kinase (ALK) Inhibitors
|Description||ALK is a receptor tyrosine kinase that has been associated with several different cancers. Researchers at St. Jude have designed, synthesized and tested a novel kinase inhibitor template. Compounds based on this core template demonstrate activity and selectivity for ALK, indicating they are suitable starting points for the development of more active lead-like inhibitors.|
|Keywords||NPM-ALK, kinase, lymphoma, cancer, inhibitor|
|Granted Patents or Published Applications||Pending provisional application|
|Related Scientific References||Slavish P. Jake et al; Design and synthesis of a novel tyrosine kinase inhibitor template; Bioorganic & Medicinal Chemistry 17 (2009) 3308 – 3316.|
|Licensing Opportunities||We are currently seeking licensing opportunities in all fields for this technology.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: September 2009